target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,ivermectin,2373,,6427057,CO[C@H]1C[C@H](OC2C(C)/C=C/C=C/3\COC4C3(O)[C@@H](C=C([C@H]4O)C)C(=O)O[C@H]3CC(C/C=C/2\C)O[C@]2(C3)CCC(C(O2)C(CC)C)C)O[C@H](C1O[C@H]1C[C@H](OC)C([C@@H](O1)C)O)C,"InChI=1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25?,26?,28?,30-,31-,33?,34-,35-,36-,37-,38-,39-,40+,41?,42?,43?,44?,45?,47+,48?/m0/s1",AZSNMRSAGSSBNP-ZLRQRZFZSA-N,Allosteric modulator,Positive,,,,,pEC50,,5.1,,EC50,,9000.0,,=,,,,9463487, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,4BP-TQS,3962,,2857838,Brc1ccc(cc1)C1Nc2ccc(cc2C2C1CC=C2)S(=O)(=O)N,"InChI=1S/C18H17BrN2O2S/c19-12-6-4-11(5-7-12)18-15-3-1-2-14(15)16-10-13(24(20,22)23)8-9-17(16)21-18/h1-2,4-10,14-15,18,21H,3H2,(H2,20,22,23)",YNCXHXYZTLIZTO-UHFFFAOYSA-N,Agonist,Full agonist,allosteric,,,,,,,,,,,,=,,,,21436053, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,α-bungarotoxin,3964,,,,,,Antagonist,Antagonist,(α7)5,,,,,,,,,,,,=,,,,, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,α-conotoxin ImI,3965,,,,,,Antagonist,Antagonist,(α7)5,,,,,,,,,,,,=,,,,, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,JNJ1930942,3966,,44240744,OCc1sc(nc1c1ccncc1)Nc1ccc(c(c1)C(F)(F)F)F,"InChI=1S/C16H11F4N3OS/c17-12-2-1-10(7-11(12)16(18,19)20)22-15-23-14(13(8-24)25-15)9-3-5-21-6-4-9/h1-7,24H,8H2,(H,22,23)",JBSVHWCIKVSTTH-UHFFFAOYSA-N,Allosteric modulator,Positive,(α7)5:Type 1/2,,,,,,,,,,,,=,,,,21084390, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,PSAB-OFP,3968,,16727408,c1ccc(cc1)c1cnc2c(c1)C[C@]1(O2)CN2CCC1CC2,"InChI=1S/C19H20N2O/c1-2-4-14(5-3-1)16-10-15-11-19(22-18(15)20-12-16)13-21-8-6-17(19)7-9-21/h1-5,10,12,17H,6-9,11,13H2/t19-/m0/s1",GIRLVGYIIVFTLI-IBGZPJMESA-N,Agonist,Full agonist,,,,,pEC50,,5.7,,EC50,,2200.0,,=,,,,12354563, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,bradanicline,3969,,25147644,O=C(c1cc2c(o1)cccc2)N[C@@H]1C2CCN([C@H]1Cc1cccnc1)CC2,"InChI=1S/C22H23N3O2/c26-22(20-13-17-5-1-2-6-19(17)27-20)24-21-16-7-10-25(11-8-16)18(21)12-15-4-3-9-23-14-15/h1-6,9,13-14,16,18,21H,7-8,10-12H2,(H,24,26)/t18-,21+/m0/s1",OXKRFEWMSWPKKV-GHTZIAJQSA-N,Agonist,Full agonist,(α7)5,,,,,,,,,,,,=,,,,19482012, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,[3H]AZ11637326,3971,,73755064,Fc1cccc(c1)c1cnc2c(c1)C[C@]1(O2)CN2CCC1CC2,"InChI=1S/C19H19FN2O/c20-17-3-1-2-13(9-17)15-8-14-10-19(23-18(14)21-11-15)12-22-6-4-16(19)5-7-22/h1-3,8-9,11,16H,4-7,10,12H2/t19-/m0/s1",MRVNNESNVNUKCV-IBGZPJMESA-N,Agonist,Full agonist,(α7)5,,,,pKd,,9.64,,Kd,,0.23,,=,,,,20674564, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,[125I]α-bungarotoxin,3972,,,,,,Antagonist,Antagonist,(α7)5,,,,pKd,9.15,,8.3,Kd,5.0,,0.7,=,,,,, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,[3H]A-585539,3974,,23643135,C[N+]1(C)CC2CC1CN2c1ccc(nn1)c1ccccc1,"InChI=1S/C17H21N4/c1-21(2)12-14-10-15(21)11-20(14)17-9-8-16(18-19-17)13-6-4-3-5-7-13/h3-9,14-15H,10-12H2,1-2H3/q+1",AKMKIDQMKPFYDJ-UHFFFAOYSA-N,Agonist,Full agonist,native α7,,,,pKd,,10.15,,Kd,,0.07,,=,,,,17959745, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,[3H]epibatidine,3977,,1204,Clc1ccc(cn1)C1CC2NC1CC2,"InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2",NLPRAJRHRHZCQQ-UHFFFAOYSA-N,Agonist,Full agonist,(α7)5,,,,pKd,,12.22,,Kd,,6.0E-4,,=,,,,, nicotinic acetylcholine receptor α7 subunit,468,Q05941,Rat,[3H]methyllycaconitine,3980,,5288811,CCN1C[C@@]2(CC[C@@H]([C@]34[C@H]1[C@](O)([C@H]([C@H]23)OC)[C@@]1([C@@H]2[C@H]4C[C@@H]([C@@H]2OC)[C@H](C1)OC)O)OC)COC(=O)c1ccccc1N1C(=O)C[C@@H](C1=O)C,"InChI=1S/C37H50N2O10/c1-7-38-17-34(18-49-32(42)20-10-8-9-11-23(20)39-26(40)14-19(2)31(39)41)13-12-25(46-4)36-22-15-21-24(45-3)16-35(43,27(22)28(21)47-5)37(44,33(36)38)30(48-6)29(34)36/h8-11,19,21-22,24-25,27-30,33,43-44H,7,12-18H2,1-6H3/t19-,21+,22+,24-,25-,27+,28-,29+,30-,33-,34-,35+,36-,37+/m0/s1",XLTANAWLDBYGFU-VTLKBQQISA-N,Antagonist,Antagonist,native α7*,,,,pKd,,8.72,,Kd,,1.9,,=,,,,, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,[3H]α-bungarotoxin,3981,,,,,,Antagonist,Antagonist,(α7)5,,,,pKd,9.15,,8.3,Kd,5.0,,0.7,=,,,,, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,A-867744,3986,,23642319,CCC(=O)c1cc(n(c1C)c1ccc(cc1)S(=O)(=O)N)c1ccc(cc1)Cl,"InChI=1S/C20H19ClN2O3S/c1-3-20(24)18-12-19(14-4-6-15(21)7-5-14)23(13(18)2)16-8-10-17(11-9-16)27(22,25)26/h4-12H,3H2,1-2H3,(H2,22,25,26)",ABACVOXFUHDKNZ-UHFFFAOYSA-N,Allosteric modulator,Positive,(α7)5:Type 2; also blocks α3β4 and α4β2,,,,,,,,,,,,=,,,,19389923, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,PNU-282987,3988,,9795278,O=C(c1ccc(cc1)Cl)N[C@H]1CN2CCC1CC2,"InChI=1S/C14H17ClN2O/c15-12-3-1-11(2-4-12)14(18)16-13-9-17-7-5-10(13)6-8-17/h1-4,10,13H,5-9H2,(H,16,18)/t13-/m0/s1",WECKJONDRAUFDD-ZDUSSCGKSA-N,Agonist,Full agonist,(α7)5,,,,,,,,,,,,=,,,,15715459, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,mecamylamine,3990,,4032,CNC1(C)C2CCC(C1(C)C)C2,"InChI=1S/C11H21N/c1-10(2)8-5-6-9(7-8)11(10,3)12-4/h8-9,12H,5-7H2,1-4H3",IMYZQPCYWPFTAG-UHFFFAOYSA-N,Channel blocker,None,(α7)5,,,,pIC50,,4.81,,IC50,,15600.0,,=,,,,, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,PNU-120596,3991,,311434,COc1cc(OC)c(cc1NC(=O)Nc1noc(c1)C)Cl,"InChI=1S/C13H14ClN3O4/c1-7-4-12(17-21-7)16-13(18)15-9-5-8(14)10(19-2)6-11(9)20-3/h4-6H,1-3H3,(H2,15,16,17,18)",CEIIEALEIHQDBX-UHFFFAOYSA-N,Allosteric modulator,Positive,(α7)5:Type 2,,,,,,,,,,,,=,,,,15858066, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,LY2087101,3992,,11964458,Fc1ccc(cc1)Nc1nc(c(s1)C(=O)c1cscc1)C,"InChI=1S/C15H11FN2OS2/c1-9-14(13(19)10-6-7-20-8-10)21-15(17-9)18-12-4-2-11(16)3-5-12/h2-8H,1H3,(H,17,18)",PEAMDZVDNYENPN-UHFFFAOYSA-N,Allosteric modulator,Positive,(α7)5:Type 1,,,,,,,,,,,,=,,,,16738207, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,A-582941,3995,,11173546,CN1CC2C(C1)CN(C2)c1ccc(nn1)c1ccccc1,"InChI=1S/C17H20N4/c1-20-9-14-11-21(12-15(14)10-20)17-8-7-16(18-19-17)13-5-3-2-4-6-13/h2-8,14-15H,9-12H2,1H3",GTMRUYCIJSNXGB-UHFFFAOYSA-N,Agonist,Full agonist,(α7)5,,,,,,,,,,,,=,,,,17898229, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,PHA-709829,3997,,10107234,O=C(c1ncc2c(c1)cco2)N[C@@H]1C[C@H]2CCN(C1)C2,"InChI=1S/C15H17N3O2/c19-15(13-6-11-2-4-20-14(11)7-16-13)17-12-5-10-1-3-18(8-10)9-12/h2,4,6-7,10,12H,1,3,5,8-9H2,(H,17,19)/t10-,12-/m1/s1",PTGWFYYEAUFEAS-ZYHUDNBSSA-N,Agonist,Full agonist,(α7)5,,,,,,,,,,,,=,,,,18490160, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,PHA-543613,3998,,9930121,O=C(c1ncc2c(c1)cco2)N[C@H]1CN2CCC1CC2,"InChI=1S/C15H17N3O2/c19-15(12-7-11-3-6-20-14(11)8-16-12)17-13-9-18-4-1-10(13)2-5-18/h3,6-8,10,13H,1-2,4-5,9H2,(H,17,19)/t13-/m0/s1",IPKZCLGGYKRDES-ZDUSSCGKSA-N,Agonist,Full agonist,(α7)5,,,,,,,,,,,,=,,,,16821801, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,NS1738,4000,,310378,O=C(Nc1cc(Cl)ccc1O)Nc1cc(ccc1Cl)C(F)(F)F,"InChI=1S/C14H9Cl2F3N2O2/c15-8-2-4-12(22)11(6-8)21-13(23)20-10-5-7(14(17,18)19)1-3-9(10)16/h1-6,22H,(H2,20,21,23)",OUDXRNQPVSMGDW-UHFFFAOYSA-N,Allosteric modulator,Positive,(α7)5:Type 1; also blocks α3β4 and α4β2,,,,,,,,,,,,=,,,,17625074, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,methyllycaconitine,4005,,5288811,CCN1C[C@@]2(CC[C@@H]([C@]34[C@H]1[C@](O)([C@H]([C@H]23)OC)[C@@]1([C@@H]2[C@H]4C[C@@H]([C@@H]2OC)[C@H](C1)OC)O)OC)COC(=O)c1ccccc1N1C(=O)C[C@@H](C1=O)C,"InChI=1S/C37H50N2O10/c1-7-38-17-34(18-49-32(42)20-10-8-9-11-23(20)39-26(40)14-19(2)31(39)41)13-12-25(46-4)36-22-15-21-24(45-3)16-35(43,27(22)28(21)47-5)37(44,33(36)38)30(48-6)29(34)36/h8-11,19,21-22,24-25,27-30,33,43-44H,7,12-18H2,1-6H3/t19-,21+,22+,24-,25-,27+,28-,29+,30-,33-,34-,35+,36-,37+/m0/s1",XLTANAWLDBYGFU-VTLKBQQISA-N,Antagonist,Antagonist,(α7)5,,,,,,,,,,,,=,,,,, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,α-conotoxin ArIB,4007,,155817466,CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)O)C(C)C,"InChI=1S/C71H113N25O26S4/c1-29(2)52(66(117)85-37(19-47(73)98)58(109)86-38(20-48(74)99)68(119)96-16-8-11-46(96)65(116)84-36(17-32-22-78-28-80-32)59(110)94-53(30(3)4)67(118)92-44(27-126)70(121)122)93-57(108)34(9-6-14-79-71(76)77)83-61(112)41(24-123)89-54(105)31(5)81-64(115)45-10-7-15-95(45)69(120)39(21-49(75)100)87-60(111)40(23-97)88-62(113)42(25-124)91-63(114)43(26-125)90-56(107)35(12-13-50(101)102)82-55(106)33(72)18-51(103)104/h22,28-31,33-46,52-53,97,123-126H,6-21,23-27,72H2,1-5H3,(H2,73,98)(H2,74,99)(H2,75,100)(H,78,80)(H,81,115)(H,82,106)(H,83,112)(H,84,116)(H,85,117)(H,86,109)(H,87,111)(H,88,113)(H,89,105)(H,90,107)(H,91,114)(H,92,118)(H,93,108)(H,94,110)(H,101,102)(H,103,104)(H,121,122)(H4,76,77,79)/t31-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,52-,53-/m0/s1",YRXAPIQPBSKAMJ-WDCFXWORSA-N,Antagonist,Antagonist,(α7)5,,,,,,,,,,,,=,,,,, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,encenicline,6926,,46196517,O=C(c1cc2c(s1)c(Cl)ccc2)N[C@H]1CN2CCC1CC2,"InChI=1S/C16H17ClN2OS/c17-12-3-1-2-11-8-14(21-15(11)12)16(20)18-13-9-19-6-4-10(13)5-7-19/h1-3,8,10,13H,4-7,9H2,(H,18,20)/t13-/m0/s1",SSRDSYXGYPJKRR-ZDUSSCGKSA-N,Agonist,Partial agonist,,,yes,,pKi,,8.37,,Ki,,4.3,,=,,,,15293871|21919481, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,AQW051,7371,,50914822,Cc1ccc(cc1)c1ccc(cn1)O[C@H]1CN2CCC1CC2,"InChI=1S/C19H22N2O/c1-14-2-4-15(5-3-14)18-7-6-17(12-20-18)22-19-13-21-10-8-16(19)9-11-21/h2-7,12,16,19H,8-11,13H2,1H3/t19-/m0/s1",NPDLTEZXGWRMLQ-IBGZPJMESA-N,Agonist,Agonist,[125I]α- bungarotoxin binding assay,,,,pKi,,7.57,,Ki,,27.0,,=,,,,, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,AZD0328,7697,,9794392,c1cnc2c(c1)C[C@]1(O2)CN2CCC1CC2,"InChI=1S/C13H16N2O/c1-2-10-8-13(16-12(10)14-5-1)9-15-6-3-11(13)4-7-15/h1-2,5,11H,3-4,6-9H2/t13-/m0/s1",OCKIPDMKGPYYJS-ZDUSSCGKSA-N,Agonist,Full agonist,,,yes,,pKi,,8.52,,Ki,,3.0,,=,,,,21919481, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,atracurium,9537,,47319,COc1cc2c(cc1OC)CC[N+](C2Cc1ccc(c(c1)OC)OC)(C)CCC(=O)OCCCCCOC(=O)CC[N+]1(C)CCc2c(C1Cc1ccc(c(c1)OC)OC)cc(c(c2)OC)OC,"InChI=1S/C53H72N2O12/c1-54(22-18-38-32-48(62-7)50(64-9)34-40(38)42(54)28-36-14-16-44(58-3)46(30-36)60-5)24-20-52(56)66-26-12-11-13-27-67-53(57)21-25-55(2)23-19-39-33-49(63-8)51(65-10)35-41(39)43(55)29-37-15-17-45(59-4)47(31-37)61-6/h14-17,30-35,42-43H,11-13,18-29H2,1-10H3/q+2",YXSLJKQTIDHPOT-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pIC50,8.25,,7.89,IC50,13.0,,5.6,=,"Antagonism of ACh activation of human α7 nACh receptors expressed in Xenopus oocytes, at different ACh concentrations.",,,16931985, nicotinic acetylcholine receptor α7 subunit,468,P36544,Human,BNC375,10693,,118160666,COc1ccc(cc1NC[C@@H]1[C@H](C1(C)C)c1ccc(cc1)S(=O)(=O)N)Cl,"InChI=1S/C19H23ClN2O3S/c1-19(2)15(11-22-16-10-13(20)6-9-17(16)25-3)18(19)12-4-7-14(8-5-12)26(21,23)24/h4-10,15,18,22H,11H2,1-3H3,(H2,21,23,24)/t15-,18-/m1/s1",LWWDCTBUJUEFDE-CRAIPNDOSA-N,Allosteric modulator,Positive,,,,,pEC50,,5.58,,EC50,,2640.0,,=,,,,32094294, nicotinic acetylcholine receptor α7 subunit,468,Q05941,Rat,BNC375,10693,,118160666,COc1ccc(cc1NC[C@@H]1[C@H](C1(C)C)c1ccc(cc1)S(=O)(=O)N)Cl,"InChI=1S/C19H23ClN2O3S/c1-19(2)15(11-22-16-10-13(20)6-9-17(16)25-3)18(19)12-4-7-14(8-5-12)26(21,23)24/h4-10,15,18,22H,11H2,1-3H3,(H2,21,23,24)/t15-,18-/m1/s1",LWWDCTBUJUEFDE-CRAIPNDOSA-N,Allosteric modulator,Positive,,,,,pEC50,,5.72,,EC50,,1900.0,,=,,,,31097995, nicotinic acetylcholine receptor α7 subunit,468,Q05941,Rat,NS6740,11383,,10021664,O=C(N1CCN2CCC1CC2)c1ccc(o1)c1cccc(c1)C(F)(F)F,"InChI=1S/C19H19F3N2O2/c20-19(21,22)14-3-1-2-13(12-14)16-4-5-17(26-16)18(25)24-11-10-23-8-6-15(24)7-9-23/h1-5,12,15H,6-11H2",VSOWCIMCDKXVRC-UHFFFAOYSA-N,Agonist,None,,,,,pKi,,8.96,,Ki,,1.1,,=,"Binding affinity to rat brain α7 nAChR, measured by displacement of the α7-selective agonist [3H]A-585539.",,,19845675, nicotinic acetylcholine receptor α7 subunit,468,Q05941,Rat,GTS-21,11384,,5310985,COc1cc(OC)ccc1/C=C/1\CCCN=C1c1cccnc1,"InChI=1S/C19H20N2O2/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16/h3,6-9,11-13H,4-5,10H2,1-2H3/b15-11+",RPYWXZCFYPVCNQ-RVDMUPIBSA-N,Agonist,Agonist,,,,,pKi,,6.66,,Ki,,220.0,,=,Inhibition of [125I]alpha-bungarotoxin binding to rat α nAChR,,,15801858, nicotinic acetylcholine receptor α7 subunit,468,Q05941,Rat,4OH-GTS-21,11385,,135508231,COc1cc(O)ccc1/C=C/1\CCCN=C1c1cccnc1,"InChI=1S/C18H18N2O2/c1-22-17-11-16(21)7-6-13(17)10-14-4-3-9-20-18(14)15-5-2-8-19-12-15/h2,5-8,10-12,21H,3-4,9H2,1H3/b14-10+",KXAAIPFSUGPVMQ-GXDHUFHOSA-N,Agonist,Agonist,,,,,pKi,,6.38,,Ki,,420.0,,=,Displacement of [3H]-methyllycaconitine from rat α7 nAChR in hippocampal membranes by liquid scintillation counting,,,21986237,