target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id 5-HT3AB,378,,Human,5-hydroxytryptamine,5,,5202,NCCc1c[nH]c2c1cc(O)cc2,"InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2",QZAYGJVTTNCVMB-UHFFFAOYSA-N,Agonist,Agonist,,yes,,,pEC50,5.8,,4.8,,,,,=,,,,9950429|10521471|16081679|10825381, 5-HT3AB,378,,Human,5-hydroxytryptamine,5,,5202,NCCc1c[nH]c2c1cc(O)cc2,"InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2",QZAYGJVTTNCVMB-UHFFFAOYSA-N,Agonist,Agonist,,yes,,,pKi,,6.0,,,,,,=,,,,11489465, 5-HT3AB,378,,Human,quipazine,173,,5011,N1CCN(CC1)c1ccc2c(n1)cccc2,"InChI=1S/C13H15N3/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16/h1-6,14H,7-10H2",XRXDAJYKGWNHTQ-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKi,,9.0,,,,,,=,,,,11489465, 5-HT3AB,378,,Human,2-methyl-5-HT,218,,1574,Cc1c(CCN)c2c([nH]1)ccc(c2)O,"InChI=1S/C11H14N2O/c1-7-9(4-5-12)10-6-8(14)2-3-11(10)13-7/h2-3,6,13-14H,4-5,12H2,1H3",WYWNEDARFVJQSG-UHFFFAOYSA-N,Agonist,Agonist,,,,,pEC50,,4.9,,,,,,=,,,,9950429, 5-HT3AB,378,,Human,metoclopramide,241,,4168,CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC,"InChI=1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)",TTWJBBZEZQICBI-UHFFFAOYSA-N,Antagonist,Antagonist,,,yes,,pKi,,5.7,,,,,,=,,,,11489465, 5-HT3AB,378,,Human,ginkgolide B,1862,,441294,O=C1O[C@@H]2[C@@]([C@@H]1C)(O)[C@@]13C4(C2O)[C@H](OC3=O)C[C@H](C24[C@H](O1)OC(=O)C2O)C(C)(C)C,"InChI=1S/C20H24O10/c1-6-12(23)28-11-9(21)18-8-5-7(16(2,3)4)17(18)10(22)13(24)29-15(17)30-20(18,14(25)27-8)19(6,11)26/h6-11,15,21-22,26H,5H2,1-4H3/t6-,7+,8-,9?,10?,11+,15+,17?,18?,19-,20-/m1/s1",SQOJOAFXDQDRGF-OOHPMXMZSA-N,Channel blocker,None,,,,,pIC50,,2.41,,IC50,,3900000.0,,=,,,,21059362, 5-HT3AB,378,,Human,1-phenylbiguanide,2284,,4780,NC(=Nc1ccccc1)N=C(N)N,"InChI=1S/C8H11N5/c9-7(10)13-8(11)12-6-4-2-1-3-5-6/h1-5H,(H6,9,10,11,12,13)",CUQCMXFWIMOWRP-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKi,,4.9,,,,,,,,,,11489465, 5-HT3AB,378,,Human,azasetron,2285,,2264,Clc1cc2N(C)C(=O)COc2c(c1)C(=O)NC1CN2CCC1CC2,"InChI=1S/C17H20ClN3O3/c1-20-14-7-11(18)6-12(16(14)24-9-15(20)22)17(23)19-13-8-21-4-2-10(13)3-5-21/h6-7,10,13H,2-5,8-9H2,1H3,(H,19,23)",WUKZPHOXUVCQOR-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.4,,,,,,,,,,11489465, 5-HT3AB,378,,Human,cocaine,2286,,446220,COC(=O)[C@H]1[C@H](C[C@H]2N([C@@H]1CC2)C)OC(=O)c1ccccc1,"InChI=1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14-,15+/m0/s1",ZPUCINDJVBIVPJ-LJISPDSOSA-N,Antagonist,Antagonist,,,,,pKi,,4.8,,,,,,,,,,11489465, 5-HT3AB,378,,Human,meta-chlorphenylbiguanide,2287,,1354,Clc1cccc(c1)N=C(N=C(N)N)N,"InChI=1S/C8H10ClN5/c9-5-2-1-3-6(4-5)13-8(12)14-7(10)11/h1-4H,(H6,10,11,12,13,14)",DIHXJZHAIHGSAW-UHFFFAOYSA-N,Agonist,Agonist,,,,,pEC50,,5.7,,,,,,=,,,,9950429, 5-HT3AB,378,,Human,meta-chlorphenylbiguanide,2287,,1354,Clc1cccc(c1)N=C(N=C(N)N)N,"InChI=1S/C8H10ClN5/c9-5-2-1-3-6(4-5)13-8(12)14-7(10)11/h1-4H,(H6,10,11,12,13,14)",DIHXJZHAIHGSAW-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKi,,7.0,,,,,,=,,,,11489465, 5-HT3AB,378,,Human,(R)-zacopride,2288,,9819593,COc1cc(N)c(cc1C(=O)N[C@H]1CN2CCC1CC2)Cl,"InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)/t13-/m0/s1",FEROPKNOYKURCJ-ZDUSSCGKSA-N,Antagonist,Antagonist,,,,,pKi,,7.7,,,,,,,,,,11489465, 5-HT3AB,378,,Human,(S)-zacopride,2289,,6604914,COc1cc(N)c(cc1C(=O)N[C@@H]1CN2CCC1CC2)Cl,"InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)/t13-/m1/s1",FEROPKNOYKURCJ-CYBMUJFWSA-N,Antagonist,Antagonist,,,,,pKi,,8.8,,,,,,,,,,11489465, 5-HT3AB,378,,Human,ondansetron,2290,,4595,O=C1C(CCc2c1c1ccccc1n2C)Cn1ccnc1C,"InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3",FELGMEQIXOGIFQ-UHFFFAOYSA-N,Antagonist,Antagonist,,,yes,,pKi,,7.8,,,,,,=,,,,11489465, 5-HT3AB,378,,Human,picrotoxinin,2291,,442292,CC(=C)[C@@H]1[C@H]2OC(=O)[C@@H]1[C@]1([C@]3([C@@H]2OC(=O)[C@]23[C@@H](C1)O2)C)O,"InChI=1S/C15H16O6/c1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h6-10,18H,1,4H2,2-3H3/t6-,7+,8-,9-,10-,13-,14-,15+/m1/s1",PIMZUZSSNYHVCU-YKWPQBAZSA-N,Channel blocker,None,,,,,pIC50,,4.2,,IC50,,63000.0,,=,,,,21059362, 5-HT3AB,378,,Human,[3H]granisetron,2292,,3510,CN1C2CCCC1CC(C2)NC(=O)c1nn(c2c1cccc2)C,"InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)",MFWNKCLOYSRHCJ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKd,,8.8,,,,,,,,,,11489465, 5-HT3AB,378,,Mouse,trichloroethanol,2293,,8259,OCC(Cl)(Cl)Cl,"InChI=1S/C2H3Cl3O/c3-2(4,5)1-6/h6H,1H2",KPWDGTGXUYRARH-UHFFFAOYSA-N,Allosteric modulator,Positive,increased rate of channel activation,,,250-10000,,,,,,,,,,,,,16257471, 5-HT3AB,378,,Human,tubocurarine,2294,,6000,COc1cc2CCN([C@@H]3c2cc1Oc1cc(ccc1O)C[C@@H]1c2c(CC[N+]1(C)C)cc(c(c2Oc1ccc(C3)cc1)O)OC)C,"InChI=1S/C37H40N2O6/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41)/p+1/t28-,29+/m0/s1",JFJZZMVDLULRGK-URLMMPGGSA-O,Antagonist,Antagonist,,,,,pKi,,4.5,,,,,,,,,,11489465, 5-HT3AB,378,,Human,bilobalide,2366,,73581,O=C1O[C@@H]2[C@@]3(C1)C(=O)O[C@H]1[C@]3([C@](C2)(O)C(C)(C)C)[C@@H](O)C(=O)O1,"InChI=1S/C15H18O8/c1-12(2,3)14(20)4-6-13(5-7(16)21-6)10(19)23-11-15(13,14)8(17)9(18)22-11/h6,8,11,17,20H,4-5H2,1-3H3/t6-,8-,11-,13-,14+,15+/m0/s1",MOLPUWBMSBJXER-YDGSQGCISA-N,Channel blocker,None,,,,,pIC50,,2.51,,IC50,,3100000.0,,=,,,,21059362, 5-HT3AB,378,,Mouse,picrotoxin,4051,,31304,CC(=C)[C@@H]1C2OC(=O)C1[C@]1([C@]3([C@@H]2OC(=O)[C@]23C(C1)O2)C)O.O=C1OC2[C@H](C1[C@]1(O)C[C@@H]3[C@]4([C@@]1([C@@H]2OC4=O)C)O3)C(O)(C)C,"InChI=1S/C15H18O7.C15H16O6/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9;1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h5-9,18-19H,4H2,1-3H3;6-10,18H,1,4H2,2-3H3/t5-,6+,7?,8?,9-,13-,14-,15+;6?,7-,8?,9?,10+,13+,14+,15-/m10/s1",VJKUPQSHOVKBCO-ZTYBEOBUSA-N,Channel blocker,None,,,,,pIC50,,2.9,,,,,,=,,,,15814570|14625088, 5-HT3AB,378,,Human,CSTI-300,10699,,57989460,O=C1N(CCc2c3c1cccc3n[nH]2)[C@@H]1CN2CCC1CC2,"InChI=1S/C17H20N4O/c22-17-12-2-1-3-13-16(12)14(19-18-13)6-9-21(17)15-10-20-7-4-11(15)5-8-20/h1-3,11,15H,4-10H2,(H,18,19)/t15-/m1/s1",WHLXDRXTKZLGFK-OAHLLOKOSA-N,Agonist,Partial agonist,,,,,pKi,,8.8,,Ki,,1.59,,=,,,,32102919,