target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id NADPH oxidase 4,3004,Q9NPH5,Human,compound 7c [PMID: 22041175],9931,,51035721,Clc1ccccc1n1[nH]c2c(c1=O)c1CN(CCCn1c(=O)c2)Cc1ccccc1,"InChI=1S/C23H21ClN4O2/c24-17-9-4-5-10-19(17)28-23(30)22-18(25-28)13-21(29)27-12-6-11-26(15-20(22)27)14-16-7-2-1-3-8-16/h1-5,7-10,13,25H,6,11-12,14-15H2",DISVMXDWAMMVLT-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pKi,,7.14,,Ki,,72.0,,=,,,,22041175, NADPH oxidase 4,3004,Q9NPH5,Human,setanaxib,9932,,58496428,Clc1ccccc1n1[nH]c2c(c1=O)c(c1cccc(c1)N(C)C)n(c(=O)c2)C,"InChI=1S/C21H19ClN4O2/c1-24(2)14-8-6-7-13(11-14)20-19-16(12-18(27)25(20)3)23-26(21(19)28)17-10-5-4-9-15(17)22/h4-12,23H,1-3H3",RGYQPQARIQKJKH-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pKi,,6.96,,Ki,,110.0,,=,,,,22806357, NADPH oxidase 4,3004,Q9NPH5,Human,compound 87 [PMID: 20942471],9934,,49836405,CN(Cc1n(Cc2ccn(n2)C)c(=O)cc2c1c(=O)n([nH]2)c1ccccc1Cl)Cc1cccnc1,"InChI=1S/C25H24ClN7O2/c1-30(14-17-6-5-10-27-13-17)16-22-24-20(12-23(34)32(22)15-18-9-11-31(2)28-18)29-33(25(24)35)21-8-4-3-7-19(21)26/h3-13,29H,14-16H2,1-2H3",QEBYEVQKHRUYPE-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pKi,,7.33,,Ki,,47.0,,=,Measured as inhibition of ROS production by hNOX4 in a cell free assay using membranes prepared from cells expressing hNOX4.,,,20942471, NADPH oxidase 4,3004,Q9NPH5,Human,GKT136901,9935,,17027464,Clc1ccccc1n1[nH]c2c(c1=O)c(C)n(c(=O)c2)Cc1ccccn1,"InChI=1S/C19H15ClN4O2/c1-12-18-15(10-17(25)23(12)11-13-6-4-5-9-21-13)22-24(19(18)26)16-8-3-2-7-14(16)20/h2-10,22H,11H2,1H3",DNKYHHFCPXKFIY-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pKi,,6.78,,Ki,,165.0,,=,Cell free assay of ROS production by NOX4 membranes.,,,20942471,