target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id 5-HT1D receptor,3,P28221,Human,1-naphthylpiperazine,3,,1342,N1CCN(CC1)c1cccc2c1cccc2,"InChI=1S/C14H16N2/c1-2-6-13-12(4-1)5-3-7-14(13)16-10-8-15-9-11-16/h1-7,15H,8-11H2",VNICFCQJUVFULD-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,8.2,,8.1,,,,,,,,,9397179|1565658, 5-HT1D receptor,3,P28221,Human,5-CT,4,,1809,NCCc1c[nH]c2c1cc(cc2)C(=O)N,"InChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15)",WKZLNEWVIAGNAW-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,9.2,,8.6,,,,,,,,,1565658|8967979|1652050, 5-HT1D receptor,3,P28221,Human,5-hydroxytryptamine,5,,5202,NCCc1c[nH]c2c1cc(O)cc2,"InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2",QZAYGJVTTNCVMB-UHFFFAOYSA-N,Agonist,Full agonist,,yes,,,pKi,9.0,,8.0,,,,,,,,,1565658|9208142|9776361|10431754|8967979|8957260|1652050, 5-HT1D receptor,3,P28221,Human,7-methoxy-1-naphthylpiperazine,6,,14533720,O=C(OCC1OC1)NCC[Si]([Si](C)(C)C)(C)C,"InChI=1S/C11H25NO3Si2/c1-16(2,3)17(4,5)7-6-12-11(13)15-9-10-8-14-10/h10H,6-9H2,1-5H3,(H,12,13)",RMYUPIFLALKWOD-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,9.2,,,,,,,,,,9397179, 5-HT1D receptor,3,P28221,Human,8-OH-DPAT,7,,1220,CCCN(C1CCc2c(C1)c(O)ccc2)CCC,"InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3",ASXGJMSKWNBENU-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,7.3,,6.9,,,,,,,,,10193663|9303569|8967979, 5-HT1D receptor,3,P28221,Human,BRL-15572,10,,3654103,Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O,"InChI=1S/C25H27ClN2O/c26-22-12-7-13-23(18-22)28-16-14-27(15-17-28)19-24(29)25(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h1-13,18,24-25,29H,14-17,19H2",QJHCTHPYUOXOGM-UHFFFAOYSA-N,Agonist,Partial agonist,,,,,pKi,,7.9,,,,,,=,,,,9303567, 5-HT1D receptor,3,P28221,Human,EMDT,12,,6918513,CCc1[nH]c2c(c1CCN(C)C)cc(cc2)OC,"InChI=1S/C15H22N2O/c1-5-14-12(8-9-17(2)3)13-10-11(18-4)6-7-15(13)16-14/h6-7,10,16H,5,8-9H2,1-4H3",ZEYRDXUWJDGTLD-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,6.5,,,,,,,,,,10715164, 5-HT1D receptor,3,P28221,Human,GR 127935,14,,107780,COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C,"InChI=1S/C29H31N5O3/c1-19-17-23(28-30-20(2)37-32-28)9-11-25(19)21-5-7-22(8-6-21)29(35)31-24-10-12-27(36-4)26(18-24)34-15-13-33(3)14-16-34/h5-12,17-18H,13-16H2,1-4H3,(H,31,35)",YDBCEBYHYKAFRX-UHFFFAOYSA-N,Agonist,Partial agonist,,,,,pKi,9.1,,8.6,,,,,,,,,9397179|9303567|9776361|8957260|9548813, 5-HT1D receptor,3,P28221,Human,GR 127935,14,,107780,COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C,"InChI=1S/C29H31N5O3/c1-19-17-23(28-30-20(2)37-32-28)9-11-25(19)21-5-7-22(8-6-21)29(35)31-24-10-12-27(36-4)26(18-24)34-15-13-33(3)14-16-34/h5-12,17-18H,13-16H2,1-4H3,(H,31,35)",YDBCEBYHYKAFRX-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,8.6,,8.3,,,,,,,,,8967979, 5-HT1D receptor,3,P28221,Human,"L-694,247",15,,132059,NCCc1c[nH]c2c1cc(cc2)c1onc(n1)Cc1ccc(cc1)NS(=O)(=O)C,"InChI=1S/C20H21N5O3S/c1-29(26,27)25-16-5-2-13(3-6-16)10-19-23-20(28-24-19)14-4-7-18-17(11-14)15(8-9-21)12-22-18/h2-7,11-12,22,25H,8-10,21H2,1H3",HKXMQLISPYELRD-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKi,,9.0,,Ki,,1.0,,=,,,,9855638, 5-HT1D receptor,3,P28221,Human,"L-772,405",16,,9847194,OC[C@@H](c1ccc(cc1)F)NC1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1,"InChI=1S/C26H31FN6O/c27-21-5-3-19(4-6-21)26(16-34)31-22-9-12-32(13-10-22)11-1-2-20-15-28-25-8-7-23(14-24(20)25)33-17-29-30-18-33/h3-8,14-15,17-18,22,26,28,31,34H,1-2,9-13,16H2/t26-/m0/s1",HNKDAQNYMJNLCC-SANMLTNESA-N,Antagonist,Antagonist,,,,,pIC50,,9.0,,,,,,,,,,10585208, 5-HT1D receptor,3,P28221,Human,LY344864,21,,18971832,CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C,"InChI=1S/C21H22FN3O/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26)",GKWHICIUSVVNGX-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,6.2,,,,,,,,,,9395253, 5-HT1D receptor,3,P28221,Human,asenapine,22,,163091,Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C,"InChI=1S/C17H16ClNO/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19/h2-8,14-15H,9-10H2,1H3/t14-,15-/m1/s1",VSWBSWWIRNCQIJ-HUUCEWRRSA-N,Agonist,Full agonist,,,,,pKi,,8.4,,,,,,,,,,8935801, 5-HT1D receptor,3,P28221,Human,RU 24969,23,,108029,COc1ccc2c(c1)c(c[nH]2)C1=CCNCC1,"InChI=1S/C14H16N2O/c1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10/h2-4,8-9,15-16H,5-7H2,1H3",KRVMLPUDAOWOGN-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,7.7,,,,,,,,,,1652050, 5-HT1D receptor,3,P28221,Human,SB 216641,28,,3292447,COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C,"InChI=1S/C28H30N4O4/c1-18-16-22(27-29-19(2)36-31-27)10-12-24(18)20-6-8-21(9-7-20)28(33)30-23-11-13-25(34-5)26(17-23)35-15-14-32(3)4/h6-13,16-17H,14-15H2,1-5H3,(H,30,33)",JRNUKVFYILMMLX-UHFFFAOYSA-N,Agonist,Partial agonist,,,,,pKi,,7.6,,,,,,,,,,9303567, 5-HT1D receptor,3,P28221,Human,capeserod,29,,9805719,Nc1c(Cl)cc(c2c1OCCO2)c1nn(c(=O)o1)C1CCN(CC1)CCc1ccccc1,"InChI=1S/C23H25ClN4O4/c24-18-14-17(20-21(19(18)25)31-13-12-30-20)22-26-28(23(29)32-22)16-7-10-27(11-8-16)9-6-15-4-2-1-3-5-15/h1-5,14,16H,6-13,25H2",MDBNTXARNGRHEV-UHFFFAOYSA-N,Agonist,Partial agonist,,,,,pKi,,5.1,,,,,,,,,,12130738, 5-HT1D receptor,3,P28221,Human,[3H]8-OH-DPAT,31,,1220,CCCN(C1CCc2c(C1)c(O)ccc2)CCC,"InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3",ASXGJMSKWNBENU-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKd,,9.0,,Kd,,1.0,,=,,,,10431754, 5-HT1D receptor,3,P28221,Human,aripiprazole,34,,60795,O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl,"InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)",CEUORZQYGODEFX-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,7.2,,,,,,=,,,,12784105, 5-HT1D receptor,3,P28221,Human,bromocriptine,35,,31101,CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C,"InChI=1S/C32H40BrN5O5/c1-16(2)12-24-29(40)37-11-7-10-25(37)32(42)38(24)30(41)31(43-32,17(3)4)35-28(39)18-13-20-19-8-6-9-22-26(19)21(27(33)34-22)14-23(20)36(5)15-18/h6,8-9,13,16-18,23-25,34,42H,7,10-12,14-15H2,1-5H3,(H,35,39)/t18-,23-,24+,25+,31-,32+/m1/s1",OZVBMTJYIDMWIL-AYFBDAFISA-N,Agonist,Partial agonist,,,,,pKi,,8.0,,,,,,,,,,12388666, 5-HT1D receptor,3,P28221,Human,cabergoline,37,,54746,C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C,"InChI=1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1",KORNTPPJEAJQIU-KJXAQDMKSA-N,Agonist,Partial agonist,,,,,pKi,,8.1,,,,,,,,,,12388666, 5-HT1D receptor,3,P28221,Human,clozapine,38,,135398737,CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2,"InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3",QZUDBNBUXVUHMW-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,6.4,,,,,,,,,,8935801, 5-HT1D receptor,3,P28221,Human,donitriptan,39,,197706,NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2,"InChI=1S/C23H25N5O2/c24-8-7-18-15-26-22-6-5-20(13-21(18)22)30-16-23(29)28-11-9-27(10-12-28)19-3-1-17(14-25)2-4-19/h1-6,13,15,26H,7-12,16,24H2",SOHCKWZVTCTQBG-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,9.3,,,,,,,,,,10381763, 5-HT1D receptor,3,P28565,Rat,donitriptan,39,,197706,NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2,"InChI=1S/C23H25N5O2/c24-8-7-18-15-26-22-6-5-20(13-21(18)22)30-16-23(29)28-11-9-27(10-12-28)19-3-1-17(14-25)2-4-19/h1-6,13,15,26H,7-12,16,24H2",SOHCKWZVTCTQBG-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,9.6,,,,,,,,,,10381763, 5-HT1D receptor,3,P28221,Human,eletriptan,40,,77993,CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1,"InChI=1S/C22H26N2O2S/c1-24-12-5-6-19(24)15-18-16-23-22-10-9-17(14-21(18)22)11-13-27(25,26)20-7-3-2-4-8-20/h2-4,7-10,14,16,19,23H,5-6,11-13,15H2,1H3/t19-/m1/s1",PWVXXGRKLHYWKM-LJQANCHMSA-N,Agonist,Full agonist,,,yes,,pKi,,8.9,,Ki,,1.26,,=,,,,10193663, 5-HT1D receptor,3,P28221,Human,lisuride,43,,28864,CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC,"InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1",BKRGVLQUQGGVSM-KBXCAEBGSA-N,Agonist,Partial agonist,,,,,pKi,,9.0,,,,,,,,,,12388666, 5-HT1D receptor,3,P28221,Human,naratriptan,45,,4440,CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C,"InChI=1S/C17H25N3O2S/c1-18-23(21,22)10-7-13-3-4-17-15(11-13)16(12-19-17)14-5-8-20(2)9-6-14/h3-4,11-12,14,18-19H,5-10H2,1-2H3",AMKVXSZCKVJAGH-UHFFFAOYSA-N,Agonist,Full agonist,,,yes,,pKi,9.0,,8.4,,,,,=,,,,10193663|9303569|7780656, 5-HT1D receptor,3,P28221,Human,ocaperidone,46,,71351,Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)cccc2C,"InChI=1S/C24H25FN4O2/c1-15-4-3-10-29-23(15)26-16(2)19(24(29)30)9-13-28-11-7-17(8-12-28)22-20-6-5-18(25)14-21(20)31-27-22/h3-6,10,14,17H,7-9,11-13H2,1-2H3",ZZQNEJILGNNOEP-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,8.8,,8.7,,,,,,,,,8967979, 5-HT1D receptor,3,P28221,Human,olanzapine,47,,135398745,CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C,"InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,18H,7-10H2,1-2H3",WXPNDRBBWZMPQG-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,6.2,,,,,,,,,,8935801, 5-HT1D receptor,3,P28221,Human,pergolide,48,,47811,CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3,"InChI=1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1",YEHCICAEULNIGD-MZMPZRCHSA-N,Agonist,Partial agonist,,,,,pKi,,7.9,,,,,,,,,,12388666, 5-HT1D receptor,3,P28221,Human,quetiapine,50,,5002,OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2,"InChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2",URKOMYMAXPYINW-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,5.7,,,,,,,,,,8935801, 5-HT1D receptor,3,P28221,Human,rizatriptan,51,,5078,CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C,"InChI=1S/C15H19N5/c1-19(2)6-5-13-8-17-15-4-3-12(7-14(13)15)9-20-11-16-10-18-20/h3-4,7-8,10-11,17H,5-6,9H2,1-2H3",ULFRLSNUDGIQQP-UHFFFAOYSA-N,Agonist,Full agonist,,,yes,,pKi,,7.9,,,,,,=,,,,10193663, 5-HT1D receptor,3,P28221,Human,roxindole,52,,219050,Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2,"InChI=1S/C23H26N2O/c26-21-9-10-23-22(16-21)20(17-24-23)8-4-5-13-25-14-11-19(12-15-25)18-6-2-1-3-7-18/h1-3,6-7,9-11,16-17,24,26H,4-5,8,12-15H2",HGEYJZMMUGWEOT-UHFFFAOYSA-N,Agonist,Partial agonist,,,,,pKi,7.2,,7.0,,,,,,,,,10431754|12388666, 5-HT1D receptor,3,P28221,Human,sumatriptan,54,,5358,CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2,"InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3",KQKPFRSPSRPDEB-UHFFFAOYSA-N,Agonist,Full agonist,,,yes,,pKi,8.7,,8.0,Ki,10.0,,1.99,=,,,,10611634|10193663|1565658|8967979|1652050, 5-HT1D receptor,3,P28221,Human,terguride,56,,443951,CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC,"InChI=1S/C20H28N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,11,14,16,18,21H,4-5,9-10,12H2,1-3H3,(H,22,25)/t14-,16+,18+/m0/s1",JOAHPSVPXZTVEP-YXJHDRRASA-N,Agonist,Partial agonist,,,,,pKi,,7.8,,,,,,,,,,12388666, 5-HT1D receptor,3,P28221,Human,xanomeline,57,,60809,CCCCCCOc1nsnc1C1=CCCN(C1)C,"InChI=1S/C14H23N3OS/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12/h8H,3-7,9-11H2,1-2H3",JOLJIIDDOBNFHW-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,8.2,,,,,,,,,,9884068, 5-HT1D receptor,3,P28221,Human,ziprasidone,59,,60854,O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2,"InChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27)",MVWVFYHBGMAFLY-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,9.0,,,,,,,,,,8935801, 5-HT1D receptor,3,P28221,Human,zolmitriptan,60,,60857,CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C,"InChI=1S/C16H21N3O2/c1-19(2)6-5-12-9-17-15-4-3-11(8-14(12)15)7-13-10-21-16(20)18-13/h3-4,8-9,13,17H,5-7,10H2,1-2H3,(H,18,20)/t13-/m0/s1",ULSDMUVEXKOYBU-ZDUSSCGKSA-N,Agonist,Full agonist,,,yes,,pKi,,8.9,,,,,,=,,,,10193663, 5-HT1D receptor,3,P28221,Human,9-OH-risperidone,67,,475100,OC1CCc2n(C1)c(=O)c(c(n2)C)CCN1CCC(CC1)c1noc2c1ccc(c2)F,"InChI=1S/C23H27FN4O3/c1-14-18(23(30)28-13-17(29)3-5-21(28)25-14)8-11-27-9-6-15(7-10-27)22-19-4-2-16(24)12-20(19)31-26-22/h2,4,12,15,17,29H,3,5-11,13H2,1H3",ABWPQNZPAOAQSG-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.9,,,,,,,,,,8935801, 5-HT1D receptor,3,P28221,Human,MPDT,71,,6918515,COc1ccc2c(c1)c(CCN(C)C)c([nH]2)c1ccccc1,"InChI=1S/C19H22N2O/c1-21(2)12-11-16-17-13-15(22-3)9-10-18(17)20-19(16)14-7-5-4-6-8-14/h4-10,13,20H,11-12H2,1-3H3",VSGPGYWZVPDDSK-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.2,,,,,,,,,,10715164, 5-HT1D receptor,3,P28221,Human,SB 272183,75,,9870500,CN1CCN(CC1)c1cc2c(cc1Cl)CCN2C(=O)Nc1ccc(c2c1cccc2)c1ccncc1,"InChI=1S/C29H28ClN5O/c1-33-14-16-34(17-15-33)28-19-27-21(18-25(28)30)10-13-35(27)29(36)32-26-7-6-22(20-8-11-31-12-9-20)23-4-2-3-5-24(23)26/h2-9,11-12,18-19H,10,13-17H2,1H3,(H,32,36)",DAPBIPAGJXKFCI-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.7,,,,,,,,,,11454652, 5-HT1D receptor,3,P28221,Human,SB 649915,76,,10296414,O=C1COc2c(N1)cc(cc2)CC1CCN(CC1)CCOc1cccc2c1ccc(n2)C,"InChI=1S/C26H29N3O3/c1-18-5-7-21-22(27-18)3-2-4-24(21)31-14-13-29-11-9-19(10-12-29)15-20-6-8-25-23(16-20)28-26(30)17-32-25/h2-8,16,19H,9-15,17H2,1H3,(H,28,30)",PJSUYRBCBFPCQW-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.8,,,,,,,,,,15887956, 5-HT1D receptor,3,P28221,Human,SB 714786,77,,10287730,Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2,"InChI=1S/C26H28N4O/c1-20-10-11-23-24(28-20)8-3-9-25(23)31-18-17-29-13-15-30(16-14-29)19-22-6-2-5-21-7-4-12-27-26(21)22/h2-12H,13-19H2,1H3",RMCSKUADBRROSI-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,9.1,,Ki,,0.794,,=,,,,15887956, 5-HT1D receptor,3,P28221,Human,fluspirilene,85,,3396,Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1,"InChI=1S/C29H31F2N3O/c30-24-12-8-22(9-13-24)27(23-10-14-25(31)15-11-23)7-4-18-33-19-16-29(17-20-33)28(35)32-21-34(29)26-5-2-1-3-6-26/h1-3,5-6,8-15,27H,4,7,16-21H2,(H,32,35)",QOYHHIBFXOOADH-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.0,,,,,,,,,,8935801, 5-HT1D receptor,3,P28221,Human,haloperidol,86,,3559,Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl,"InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2",LNEPOXFFQSENCJ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.6,,,,,,,,,,8935801, 5-HT1D receptor,3,P28221,Human,ketanserin,88,,3822,Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2,"InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)",FPCCSQOGAWCVBH-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,7.5,,7.4,,,,,,,,,9303569|8967979, 5-HT1D receptor,3,P28221,Human,methiothepin,89,,4106,CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C,"InChI=1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3",RLJFTICUTYVZDG-UHFFFAOYSA-N,Antagonist,Inverse agonist,,,,,pKi,8.2,,7.3,,,,,,,,,8957260|9303569|8967979|1652050, 5-HT1D receptor,3,P28221,Human,pipamperone,92,,4830,O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N,"InChI=1S/C21H30FN3O2/c22-18-8-6-17(7-9-18)19(26)5-4-12-24-15-10-21(11-16-24,20(23)27)25-13-2-1-3-14-25/h6-9H,1-5,10-16H2,(H2,23,27)",AXKPFOAXAHJUAG-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.8,,,,,,,,,,8935801, 5-HT1D receptor,3,P28221,Human,risperidone,96,,5073,Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2,"InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3",RAPZEAPATHNIPO-UHFFFAOYSA-N,Antagonist,Antagonist,,,yes,,pKi,8.0,,7.8,,,,,=,,,,8935801|8967979, 5-HT1D receptor,3,P28221,Human,ritanserin,97,,5074,Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F,"InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3",JUQLTPCYUFPYKE-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.6,,,,,,,,,,8967979, 5-HT1D receptor,3,P28221,Human,sertindole,98,,60149,Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O,"InChI=1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31)",GZKLJWGUPQBVJQ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.2,,,,,,,,,,8935801, 5-HT1D receptor,3,P28221,Human,spiperone,99,,5265,Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1,"InChI=1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29)",DKGZKTPJOSAWFA-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,6.0,,5.5,,,,,,,,,1565658|1652050, 5-HT1D receptor,3,P28221,Human,yohimbine,102,,8969,COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1,"InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1",BLGXFZZNTVWLAY-SCYLSFHTSA-N,Antagonist,Antagonist,,,,,pKi,7.7,,7.2,,,,,,,,,10611634|1565658|8967979|1652050, 5-HT1D receptor,3,P28221,Human,zotepine,103,,5736,CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C,"InChI=1S/C18H18ClNOS/c1-20(2)9-10-21-16-11-13-5-3-4-6-17(13)22-18-8-7-14(19)12-15(16)18/h3-8,11-12H,9-10H2,1-2H3",HDOZVRUNCMBHFH-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,9.3,,,,,,,,,,8935801, 5-HT1D receptor,3,P28221,Human,5-MeOT,107,,1833,NCCc1c[nH]c2c1cc(OC)cc2,"InChI=1S/C11H14N2O/c1-14-9-2-3-11-10(6-9)8(4-5-12)7-13-11/h2-3,6-7,13H,4-5,12H2,1H3",JTEJPPKMYBDEMY-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,8.7,,7.4,,,,,,,,,1565658|8967979|1652050, 5-HT1D receptor,3,P28221,Human,CGS-12066,109,,2689,CN1CCN(CC1)c1nc2cc(ccc2n2c1ccc2)C(F)(F)F,"InChI=1S/C17H17F3N4/c1-22-7-9-23(10-8-22)16-15-3-2-6-24(15)14-5-4-12(17(18,19)20)11-13(14)21-16/h2-6,11H,7-10H2,1H3",LXFHSCDLMBZYKY-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,8.6,,8.5,,,,,,,,,1565658|1652050, 5-HT1D receptor,3,P28221,Human,CP-122288,110,,132552,CNS(=O)(=O)Cc1ccc2c(c1)c(c[nH]2)C[C@H]1CCCN1C,"InChI=1S/C16H23N3O2S/c1-17-22(20,21)11-12-5-6-16-15(8-12)13(10-18-16)9-14-4-3-7-19(14)2/h5-6,8,10,14,17-18H,3-4,7,9,11H2,1-2H3/t14-/m1/s1",BWQZTHPHLITOOZ-CQSZACIVSA-N,Agonist,Full agonist,,,,,pIC50,,7.7,,,,,,,,,,9303569, 5-HT1D receptor,3,P28221,Human,TFMPP,115,,4296,FC(c1cccc(c1)N1CCNCC1)(F)F,"InChI=1S/C11H13F3N2/c12-11(13,14)9-2-1-3-10(8-9)16-6-4-15-5-7-16/h1-3,8,15H,4-7H2",KKIMDKMETPPURN-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,7.2,,7.1,,,,,,,,,1565658|1652050, 5-HT1D receptor,3,P28221,Human,[3H]alniditan,117,,66004,C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1,"InChI=1S/C17H26N4O/c1-2-6-16-14(5-1)7-8-15(22-16)13-18-9-3-10-19-17-20-11-4-12-21-17/h1-2,5-6,15,18H,3-4,7-13H2,(H2,19,20,21)/t15-/m1/s1",QVSXOXCYXPQXMF-OAHLLOKOSA-N,Agonist,Full agonist,,,,,pKd,8.92,,8.85,Kd,1.4,,1.2,=,,,,9605573, 5-HT1D receptor,3,P28221,Human,[3H]eletriptan,118,,53318014,C([3H])(N1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1)([3H])[3H],"InChI=1S/C22H26N2O2S/c1-24-12-5-6-19(24)15-18-16-23-22-10-9-17(14-21(18)22)11-13-27(25,26)20-7-3-2-4-8-20/h2-4,7-10,14,16,19,23H,5-6,11-13,15H2,1H3/t19-/m1/s1/i1T3",PWVXXGRKLHYWKM-YWMWWHSFSA-N,Agonist,Full agonist,,,,,pKd,,9.1,,Kd,,0.9,,=,,,,10193663, 5-HT1D receptor,3,P28221,Human,[3H]sumatriptan,119,,53325948,CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C([3H])([3H])[3H])C([3H])([3H])[3H])c[nH]2,"InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3/i2T3,3T3",KQKPFRSPSRPDEB-KERYDJPLSA-N,Agonist,Full agonist,,,,,pKd,,8.2,,Kd,,7.0,,=,,,,10193663, 5-HT1D receptor,3,P28221,Human,alniditan,120,,66004,C(NC[C@H]1CCc2c(O1)cccc2)CCNC1=NCCCN1,"InChI=1S/C17H26N4O/c1-2-6-16-14(5-1)7-8-15(22-16)13-18-9-3-10-19-17-20-11-4-12-21-17/h1-2,5-6,15,18H,3-4,7-13H2,(H2,19,20,21)/t15-/m1/s1",QVSXOXCYXPQXMF-OAHLLOKOSA-N,Agonist,Full agonist,,,,,pKi,9.4,,8.7,,,,,,,,,9605573|8967979, 5-HT1D receptor,3,P28221,Human,dihydroergotamine,121,,10531,CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O,"InChI=1S/C33H37N5O5/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32/h3-6,8-11,17,21,23,25-27,34,42H,7,12-16,18H2,1-2H3,(H,35,39)/t21-,23-,25-,26+,27+,32-,33+/m1/s1",LUZRJRNZXALNLM-JGRZULCMSA-N,Agonist,Full agonist,,,yes,,pKi,9.9,,9.2,,,,,=,,,,9605573|8967979|1652050, 5-HT1D receptor,3,P28221,Human,dipropyl-5-CT,122,,156314,CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N,"InChI=1S/C17H25N3O/c1-3-8-20(9-4-2)10-7-14-12-19-16-6-5-13(17(18)21)11-15(14)16/h5-6,11-12,19H,3-4,7-10H2,1-2H3,(H2,18,21)",DPXOFRGRKPFZOD-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pIC50,,7.9,,,,,,,,,,1565658, 5-HT1D receptor,3,P28221,Human,lysergol,123,,14987,OC[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3,"InChI=1S/C16H18N2O/c1-18-8-10(9-19)5-13-12-3-2-4-14-16(12)11(7-17-14)6-15(13)18/h2-5,7,10,15,17,19H,6,8-9H2,1H3/t10-,15-/m1/s1",BIXJFIJYBLJTMK-MEBBXXQBSA-N,Agonist,Full agonist,,,,,pKi,,9.2,,,,,,,,,,1565658, 5-HT1D receptor,3,P28221,Human,oxymetazoline,124,,4636,Cc1cc(c(c(c1CC1=NCCN1)C)O)C(C)(C)C,"InChI=1S/C16H24N2O/c1-10-8-13(16(3,4)5)15(19)11(2)12(10)9-14-17-6-7-18-14/h8,19H,6-7,9H2,1-5H3,(H,17,18)",WYWIFABBXFUGLM-UHFFFAOYSA-N,Agonist,Partial agonist,,,,,pKi,,9.4,,,,,,,,,,9632357, 5-HT1D receptor,3,P28221,Human,tryptamine,125,,1150,NCCc1c[nH]c2c1cccc2,"InChI=1S/C10H12N2/c11-6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6,11H2",APJYDQYYACXCRM-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,7.4,,6.8,,,,,,,,,1565658|8967979, 5-HT1D receptor,3,P28221,Human,(+)-WAY 100135,126,,6604840,COc1ccccc1N1CCN(CC1)C[C@@H](C(=O)NC(C)(C)C)c1ccccc1,"InChI=1S/C24H33N3O2/c1-24(2,3)25-23(28)20(19-10-6-5-7-11-19)18-26-14-16-27(17-15-26)21-12-8-9-13-22(21)29-4/h5-13,20H,14-18H2,1-4H3,(H,25,28)/t20-/m1/s1",UMTDAKAAYOXIKU-HXUWFJFHSA-N,Antagonist,Antagonist,,,,,pKi,,7.6,,,,,,,,,,9208142, 5-HT1D receptor,3,P28221,Human,S33084,129,,9868452,N#Cc1ccc2c(c1)[C@H]1CN(C[C@@H]1CO2)CCCCNC(=O)c1ccc(cc1)c1ccccc1,"InChI=1S/C29H29N3O2/c30-17-21-8-13-28-26(16-21)27-19-32(18-25(27)20-34-28)15-5-4-14-31-29(33)24-11-9-23(10-12-24)22-6-2-1-3-7-22/h1-3,6-13,16,25,27H,4-5,14-15,18-20H2,(H,31,33)/t25-,27+/m1/s1",QQJHRQZZCNYDMX-VPUSJEBWSA-N,Antagonist,Antagonist,,,,,pKi,,6.9,,,,,,,,,,10869410, 5-HT1D receptor,3,P28221,Human,SB 224289,130,,3378093,CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C,"InChI=1S/C32H32N4O3/c1-20-16-25(30-33-21(2)39-34-30)8-9-26(20)22-4-6-23(7-5-22)31(37)36-13-10-24-17-29-27(18-28(24)36)32(19-38-29)11-14-35(3)15-12-32/h4-9,16-18H,10-15,19H2,1-3H3",ATQMRMGXINTJHV-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.3,,,,,,,,,,9776361|9548813, 5-HT1D receptor,3,P28221,Human,"[3H]GR 125,743",131,,53321959,COc1ccc(cc1N1CCN(CC1)C([3H])([3H])[3H])NC(=O)c1ccc(c(c1)C)c1ccncc1,"InChI=1S/C25H28N4O2/c1-18-16-20(4-6-22(18)19-8-10-26-11-9-19)25(30)27-21-5-7-24(31-3)23(17-21)29-14-12-28(2)13-15-29/h4-11,16-17H,12-15H2,1-3H3,(H,27,30)/i2T3",GNOXPYACARZYMW-BHTRQJOGSA-N,Antagonist,Antagonist,,,,,pKd,,8.6,,Kd,,2.8,,=,,,,10452531, 5-HT1D receptor,3,P28221,Human,cyanopindolol,132,,155346,N#Cc1[nH]c2c(c1)c(OCC(CNC(C)(C)C)O)ccc2,"InChI=1S/C16H21N3O2/c1-16(2,3)18-9-12(20)10-21-15-6-4-5-14-13(15)7-11(8-17)19-14/h4-7,12,18-20H,9-10H2,1-3H3",QXIUMMLTJVHILT-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.1,,,,,,,,,,1652050, 5-HT1D receptor,3,P28221,Human,metergoline,133,,28693,O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C,"InChI=1S/C25H29N3O2/c1-27-14-18(13-26-25(29)30-16-17-7-4-3-5-8-17)11-21-20-9-6-10-22-24(20)19(12-23(21)27)15-28(22)2/h3-10,15,18,21,23H,11-14,16H2,1-2H3,(H,26,29)/t18-,21+,23+/m0/s1",WZHJKEUHNJHDLS-QTGUNEKASA-N,Antagonist,Antagonist,,,,,pKi,9.2,,8.6,,,,,,,,,9303569|8967979|1652050, 5-HT1D receptor,3,P28221,Human,methysergide,134,,9681,CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO,"InChI=1S/C21H27N3O2/c1-4-15(12-25)22-21(26)14-8-17-16-6-5-7-18-20(16)13(10-23(18)2)9-19(17)24(3)11-14/h5-8,10,14-15,19,25H,4,9,11-12H2,1-3H3,(H,22,26)/t14-,15+,19-/m1/s1",KPJZHOPZRAFDTN-ZRGWGRIASA-N,Antagonist,Antagonist,,,,,pKi,8.9,,8.4,,,,,,,,,1565658|8967979, 5-HT1D receptor,3,P28221,Human,rauwolscine,136,,643606,COC(=O)[C@@H]1[C@@H](O)CC[C@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1,"InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15+,17+,18+,19+/m1/s1",BLGXFZZNTVWLAY-DIRVCLHFSA-N,Antagonist,Antagonist,,,,,pKi,,7.8,,,,,,,,,,1565658, 5-HT1D receptor,3,P28221,Human,5-HT-moduline,137,,7048566,OC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CC(C)C)C)NC(=O)[C@H](CC(C)C)N,"InChI=1S/C18H34N4O6/c1-9(2)6-12(19)16(25)22-14(8-23)17(26)20-11(5)15(24)21-13(18(27)28)7-10(3)4/h9-14,23H,6-8,19H2,1-5H3,(H,20,26)(H,21,24)(H,22,25)(H,27,28)/t11-,12-,13-,14-/m0/s1",IMIVWAUMTAIVPJ-XUXIUFHCSA-N,Allosteric modulator,Negative,,yes,,,pIC50,,12.0,,,,,,,,,,9774213, 5-HT1D receptor,3,P28221,Human,lysergic acid,139,,6717,CN1C[C@@H](C=C2C1Cc1c[nH]c3c1c2ccc3)C(=O)O,"InChI=1S/C16H16N2O2/c1-18-8-10(16(19)20)5-12-11-3-2-4-13-15(11)9(7-17-13)6-14(12)18/h2-5,7,10,14,17H,6,8H2,1H3,(H,19,20)/t10-,14?/m1/s1",ZAGRKAFMISFKIO-IAPIXIRKSA-N,Agonist,Full agonist,,,,,pKi,9.0,,8.8,,,,,,,,,8967979, 5-HT1D receptor,3,P28221,Human,dimethyltryptamine,141,,6089,CN(CCc1c[nH]c2c1cccc2)C,"InChI=1S/C12H16N2/c1-14(2)8-7-10-9-13-12-6-4-3-5-11(10)12/h3-6,9,13H,7-8H2,1-2H3",DMULVCHRPCFFGV-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,7.3,,7.0,,,,,,,,,8967979, 5-HT1D receptor,3,P28221,Human,m-chlorophenylpiperazine,142,,1355,Clc1cccc(c1)N1CCNCC1,"InChI=1S/C10H13ClN2/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13/h1-3,8,12H,4-7H2",VHFVKMTVMIZMIK-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.7,,,,,,,,,,1652050, 5-HT1D receptor,3,P28221,Human,SB 277011-A,143,,5311096,N#Cc1ccc2c(c1)CCN(C2)CC[C@@H]1CC[C@H](CC1)NC(=O)c1ccnc2c1cccc2,"InChI=1S/C28H30N4O/c29-18-21-5-8-23-19-32(16-13-22(23)17-21)15-12-20-6-9-24(10-7-20)31-28(33)26-11-14-30-27-4-2-1-3-25(26)27/h1-5,8,11,14,17,20,24H,6-7,9-10,12-13,15-16,19H2,(H,31,33)/t20-,24-",OLWRVVHPJFLNPW-LSNLESRRSA-N,Antagonist,Antagonist,,,,,pKi,,5.8,,,,,,,,,,10945872, 5-HT1D receptor,3,P28221,Human,bufotenine,144,,10257,CN(CCc1c[nH]c2c1cc(O)cc2)C,"InChI=1S/C12H16N2O/c1-14(2)6-5-9-8-13-12-4-3-10(15)7-11(9)12/h3-4,7-8,13,15H,5-6H2,1-2H3",VTTONGPRPXSUTJ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,8.0,,7.7,,,,,,,,,8967979, 5-HT1D receptor,3,P28221,Human,ergotamine,149,,8223,O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O,"InChI=1S/C33H35N5O5/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32/h3-6,8-11,15,17,21,25-27,34,42H,7,12-14,16,18H2,1-2H3,(H,35,39)/t21-,25-,26+,27+,32-,33+/m1/s1",XCGSFFUVFURLIX-VFGNJEKYSA-N,Agonist,Agonist,,,yes,,pKi,,9.1,,Ki,,0.8,,=,,,,10715164, 5-HT1D receptor,3,P28221,Human,α-methyl-5-HT,152,,2107,CC(Cc1c[nH]c2c1cc(O)cc2)N,"InChI=1S/C11H14N2O/c1-7(12)4-8-6-13-11-3-2-9(14)5-10(8)11/h2-3,5-7,13-14H,4,12H2,1H3",LYPCGXKCQDYTFV-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,6.6,,6.1,,,,,,,,,8967979, 5-HT1D receptor,3,P28221,Human,2-methyl-5-HT,218,,1574,Cc1c(CCN)c2c([nH]1)ccc(c2)O,"InChI=1S/C11H14N2O/c1-7-9(4-5-12)10-6-8(14)2-3-11(10)13-7/h2-3,6,13-14H,4-5,12H2,1H3",WYWNEDARFVJQSG-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,6.2,,5.7,,,,,,,,,1565658|8967979, 5-HT1D receptor,3,P28221,Human,[3H]5-CT,262,,53324620,NC(=O)c1ccc2c(c1)c(c[nH]2)C(C(N)([3H])[3H])([3H])[3H],"InChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15)/i3T2,4T2",WKZLNEWVIAGNAW-DOMYTETQSA-N,Agonist,Agonist,,,,,pKd,,9.1,,Kd,,0.9,,=,,,,10452531, 5-HT1D receptor,3,,Gorilla,PNU109291,3228,,9909448,CNC(=O)c1ccc2c(c1)CCO[C@H]2CCN1CCN(CC1)c1ccc(cc1)OC,"InChI=1S/C24H31N3O3/c1-25-24(28)19-3-8-22-18(17-19)10-16-30-23(22)9-11-26-12-14-27(15-13-26)20-4-6-21(29-2)7-5-20/h3-8,17,23H,9-16H2,1-2H3,(H,25,28)/t23-/m0/s1",UDLSEQDYARNKTL-QHCPKHFHSA-N,Agonist,Agonist,,,,,pKi,,9.1,,Ki,,0.9,,=,,,,9632349, 5-HT1D receptor,3,P28221,Human,[3H]5-HT,3248,,53317992,C([3H])(C(c1c[nH]c2c1cc(O)cc2)[3H])N,"InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/i3T,4T",QZAYGJVTTNCVMB-PZFLKRBQSA-N,Agonist,Full agonist,,,,,pKd,8.6,,8.2,,,,,=,,,,1565658|9776361|9605573, 5-HT1D receptor,3,P28565,Rat,[125I]GTI,3250,,73755035,NCCc1c[nH]c2c1cc(OCC(=O)NCC(=O)N[C@H](C(=O)N)Cc1ccc(c(c1)[125I])O)cc2,"InChI=1S/C23H26IN5O5/c24-17-7-13(1-4-20(17)30)8-19(23(26)33)29-21(31)11-28-22(32)12-34-15-2-3-18-16(9-15)14(5-6-25)10-27-18/h1-4,7,9-10,19,27,30H,5-6,8,11-12,25H2,(H2,26,33)(H,28,32)(H,29,31)/t19-/m0/s1/i24-2",JVQSCVCNDUJMMW-BYWNROPASA-N,Agonist,Agonist,,,,,pKd,,8.9,,Kd,,1.3,,=,,,,1738002|8361548, 5-HT1D receptor,3,P28221,Human,almotriptan,7110,,123606,CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C,"InChI=1S/C17H25N3O2S/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3",WKEMJKQOLOHJLZ-UHFFFAOYSA-N,Agonist,Agonist,,,,,pIC50,,7.89,,IC50,,13.0,,=,"Affinity of almotriptan at recombinant h5-HT1D receptors expressed in HeLa cells, determined in a radioligand displacement assay using [125I]GTI as tracer.",,,11134654, 5-HT1D receptor,3,P28221,Human,frovatriptan,7191,,77992,CN[C@H]1Cc2c(CC1)[nH]c1c2cc(cc1)C(=N)O,"InChI=1S/C14H17N3O/c1-16-9-3-5-13-11(7-9)10-6-8(14(15)18)2-4-12(10)17-13/h2,4,6,9,16-17H,3,5,7H2,1H3,(H2,15,18)/t9-/m1/s1",XPSQPHWEGNHMSK-SECBINFHSA-N,Agonist,Agonist,,,yes,,pKi,,8.36,,Ki,,4.4,,=,,,,9986723, 5-HT1D receptor,3,P28565,Rat,vortioxetine,7351,,9966051,Cc1ccc(c(c1)C)Sc1ccccc1N1CCNCC1,"InChI=1S/C18H22N2S/c1-14-7-8-17(15(2)13-14)21-18-6-4-3-5-16(18)20-11-9-19-10-12-20/h3-8,13,19H,9-12H2,1-2H3",YQNWZWMKLDQSAC-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pIC50,,5.4,,IC50,,4000.0,,=,,,,15341484, 5-HT1D receptor,3,P28221,Human,avitriptan,10446,,133081,COc1cncnc1N1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)CS(=O)(=O)NC,"InChI=1S/C22H30N6O3S/c1-23-32(29,30)15-17-5-6-20-19(12-17)18(13-25-20)4-3-7-27-8-10-28(11-9-27)22-21(31-2)14-24-16-26-22/h5-6,12-14,16,23,25H,3-4,7-11,15H2,1-2H3",WRZVGHXUPBWIOO-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKi,,8.36,,Ki,,4.37,,=,,,,9050026,