target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id DOT1 like histone lysine methyltransferase,2650,Q8TEK3,Human,bromo-deaza-SAH,7018,,53339032,OC(=O)[C@H](CCSC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cc(c2c1ncnc2N)Br)N,"InChI=1S/C15H20BrN5O5S/c16-6-3-21(13-9(6)12(18)19-5-20-13)14-11(23)10(22)8(26-14)4-27-2-1-7(17)15(24)25/h3,5,7-8,10-11,14,22-23H,1-2,4,17H2,(H,24,25)(H2,18,19,20)/t7-,8+,10+,11+,14+/m0/s1",DIULHULFPSIBAK-TWBCTODHSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.11,,IC50,,77.0,,=,,,,23433670, DOT1 like histone lysine methyltransferase,2650,Q8TEK3,Human,bromo-deaza-SAH,7018,,53339032,OC(=O)[C@H](CCSC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cc(c2c1ncnc2N)Br)N,"InChI=1S/C15H20BrN5O5S/c16-6-3-21(13-9(6)12(18)19-5-20-13)14-11(23)10(22)8(26-14)4-27-2-1-7(17)15(24)25/h3,5,7-8,10-11,14,22-23H,1-2,4,17H2,(H,24,25)(H2,18,19,20)/t7-,8+,10+,11+,14+/m0/s1",DIULHULFPSIBAK-TWBCTODHSA-N,Inhibitor,Inhibition,,,,,pKi,,7.42,,Ki,,38.0,,=,,,,23433670, DOT1 like histone lysine methyltransferase,2650,Q8TEK3,Human,pinometostat,7019,,57345410,O[C@@H]1[C@@H](CN([C@@H]2C[C@@H](C2)CCc2nc3c([nH]2)ccc(c3)C(C)(C)C)C(C)C)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N,"InChI=1S/C30H42N8O3/c1-16(2)37(13-22-25(39)26(40)29(41-22)38-15-34-24-27(31)32-14-33-28(24)38)19-10-17(11-19)6-9-23-35-20-8-7-18(30(3,4)5)12-21(20)36-23/h7-8,12,14-17,19,22,25-26,29,39-40H,6,9-11,13H2,1-5H3,(H,35,36)(H2,31,32,33)/t17-,19+,22-,25-,26-,29-/m1/s1",LXFOLMYKSYSZQS-LURJZOHASA-N,Inhibitor,Inhibition,,,,,pKi,,10.1,,Ki,,0.08,,=,,,,23801631, DOT1 like histone lysine methyltransferase,2650,Q8TEK3,Human,SGC0946,7020,,56962337,O=C(Nc1ccc(cc1)C(C)(C)C)NCCCN(C(C)C)C[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cc(c2c1ncnc2N)Br,"InChI=1S/C28H40BrN7O4/c1-16(2)35(12-6-11-31-27(39)34-18-9-7-17(8-10-18)28(3,4)5)14-20-22(37)23(38)26(40-20)36-13-19(29)21-24(30)32-15-33-25(21)36/h7-10,13,15-16,20,22-23,26,37-38H,6,11-12,14H2,1-5H3,(H2,30,32,33)(H2,31,34,39)/t20-,22-,23-,26-/m1/s1",IQCKJUKAQJINMK-HUBRGWSESA-N,Inhibitor,Inhibition,,,,,pIC50,,9.52,,IC50,,0.3,,=,,,,23250418, DOT1 like histone lysine methyltransferase,2650,Q8TEK3,Human,EPZ004777,7377,,56962336,O=C(Nc1ccc(cc1)C(C)(C)C)NCCCN(C(C)C)C[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1ccc2c1ncnc2N,"InChI=1S/C28H41N7O4/c1-17(2)34(13-6-12-30-27(38)33-19-9-7-18(8-10-19)28(3,4)5)15-21-22(36)23(37)26(39-21)35-14-11-20-24(29)31-16-32-25(20)35/h7-11,14,16-17,21-23,26,36-37H,6,12-13,15H2,1-5H3,(H2,29,31,32)(H2,30,33,38)/t21-,22-,23-,26-/m1/s1",WXRGFPHDRFQODR-ICLZECGLSA-N,Inhibitor,Inhibition,,,,,pIC50,,9.4,,IC50,,0.4,,=,,,,21741596, DOT1 like histone lysine methyltransferase,2650,Q8TEK3,Human,"compound 13 [Chen et al., 2016]",9205,,121231410,CNc1ccnc(n1)Nc1ccc2c(c1)n(c(c2)C)c1ccccc1Oc1cnc2c(c1)ncn2C,"InChI=1S/C27H24N8O/c1-17-12-18-8-9-19(32-27-29-11-10-25(28-2)33-27)13-23(18)35(17)22-6-4-5-7-24(22)36-20-14-21-26(30-15-20)34(3)16-31-21/h4-16H,1-3H3,(H2,28,29,32,33)",RQVLGMREYUFLPQ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKi,,10.1,,Ki,,0.08,,=,Scintillation proximity assay result,,,27563395,