target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id proteasome 20S subunit beta 5,2406,P28074,Human,bortezomib,6391,,387447,CC(C[C@@H](B(O)O)NC(=O)[C@@H](NC(=O)c1cnccn1)Cc1ccccc1)C,"InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1",GXJABQQUPOEUTA-RDJZCZTQSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.7,,IC50,,20.0,,=,,,,19428245, proteasome 20S subunit beta 5,2406,P28074,Human,carfilzomib,7420,,11556711,CC(C[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)[C@@]1(C)CO1)CC(C)C)Cc1ccccc1)NC(=O)[C@@H](NC(=O)CN1CCOCC1)CCc1ccccc1)C,"InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1",BLMPQMFVWMYDKT-NZTKNTHTSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.24,,IC50,,5.7,,=,,,,19348473, proteasome 20S subunit beta 5,2406,P28074,Human,ixazomib,8450,,25183872,OB([C@@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)CC(C)C)O,"InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1",MXAYKZJJDUDWDS-LBPRGKRZSA-N,Inhibitor,Inhibition,,,yes,,pKi,,9.03,,Ki,,0.93,,=,,,,20160034, proteasome 20S subunit beta 5,2406,P28074,Human,MG-132,8616,,462382,O=C[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)CC(C)C)CC(C)C)CC(C)C,"InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1",TZYWCYJVHRLUCT-VABKMULXSA-N,Inhibitor,Inhibition,,,,,pKi,,8.43,,Ki,,3.7,,=,Inhibition of the chymotrypsin-like activity of proteasome macropain.,,,16686537, proteasome 20S subunit beta 5,2406,,Bovine,compound 3b [PMID: 24946214],8618,,90645049,CC(C[C@@H](B(O)O)NC(=O)CCn1ccc2c(c1=O)cccc2)C,"InChI=1S/C17H23BN2O4/c1-12(2)11-15(18(23)24)19-16(21)8-10-20-9-7-13-5-3-4-6-14(13)17(20)22/h3-7,9,12,15,23-24H,8,10-11H2,1-2H3,(H,19,21)/t15-/m0/s1",QCKLWTRAVKQTPI-HNNXBMFYSA-N,Inhibitor,Inhibition,,,,,pKi,,8.29,,Ki,,5.1,,=,Inhibition of chymotrypsin-like activity.,,,24946214, proteasome 20S subunit beta 5,2406,P28074,Human,oprozomib,8739,,25067547,COC[C@@H](C(=O)N[C@H](C(=O)[C@]1(C)OC1)Cc1ccccc1)NC(=O)[C@@H](NC(=O)c1cnc(s1)C)COC,"InChI=1S/C25H32N4O7S/c1-15-26-11-20(37-15)24(33)29-19(13-35-4)23(32)28-18(12-34-3)22(31)27-17(21(30)25(2)14-36-25)10-16-8-6-5-7-9-16/h5-9,11,17-19H,10,12-14H2,1-4H3,(H,27,31)(H,28,32)(H,29,33)/t17-,18-,19-,25+/m0/s1",SWZXEVABPLUDIO-WSZYKNRRSA-N,Inhibitor,Inhibition,,,yes,,pIC50,8.0,,7.49,IC50,32.0,,10.0,=,,,,22978849|19348473, proteasome 20S subunit beta 5,2406,P28074,Human,zetomipzomib,10409,,117607904,COc1ccc(cc1)[C@H]([C@@H](C(=O)N[C@H](C(=O)[C@@]1(C)CO1)CC1=CCCC1)NC(=O)[C@@H](NC(=O)CN1CCOCC1)C)O,"InChI=1S/C30H42N4O8/c1-19(31-24(35)17-34-12-14-41-15-13-34)28(38)33-25(26(36)21-8-10-22(40-3)11-9-21)29(39)32-23(16-20-6-4-5-7-20)27(37)30(2)18-42-30/h6,8-11,19,23,25-26,36H,4-5,7,12-18H2,1-3H3,(H,31,35)(H,32,39)(H,33,38)/t19-,23-,25-,26+,30+/m0/s1",GHYOCDFICYLMRF-UTIIJYGPSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.16,,IC50,,688.0,,=,Inhibition of proteolytic activity measured in MOLT-4 (human T cell leukemia) cell lysate using the ProCISE ELISA.,,,30380863, proteasome 20S subunit beta 5,2406,P28074,Human,WLL-vs,11321,,118796903,CC(C[C@@H](C(=O)N[C@@H](CC(C)C)/C=C/S(=O)(=O)C)NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCOCC1)C,"InChI=1S/C31H47N5O6S/c1-21(2)16-24(10-15-43(5,40)41)33-30(38)27(17-22(3)4)35-31(39)28(34-29(37)20-36-11-13-42-14-12-36)18-23-19-32-26-9-7-6-8-25(23)26/h6-10,15,19,21-22,24,27-28,32H,11-14,16-18,20H2,1-5H3,(H,33,38)(H,34,37)(H,35,39)/b15-10+/t24-,27+,28+/m1/s1",DKBAFRHAWTVKAD-ODGLJRBPSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.0,,IC50,,1000.0,,=,,,,26863983, proteasome 20S subunit beta 5,2406,P28074,Human,NIC-0102,12174,,164946740,OB([C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1c(F)cccc1F)O,"InChI=1S/C21H25BF2N2O4/c1-13(2)11-18(22(29)30)26-20(27)17(12-14-7-4-3-5-8-14)25-21(28)19-15(23)9-6-10-16(19)24/h3-10,13,17-18,29-30H,11-12H2,1-2H3,(H,25,28)(H,26,27)/t17-,18-/m0/s1",QTRFWSIBLJYXFJ-ROUUACIJSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.43,,IC50,,3.7,,=,,,,36063115,