target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id coagulation factor XI,2360,P03951,Human,alpha-ketothiazole analogue 36,6549,,16098914,O=C(N[C@@H](c1ccc(cc1)Br)C)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)c1nccs1)CCCN=C(N)N)C(C)C)CCCNC(=O)N,"InChI=1S/C29H43BrN10O5S/c1-16(2)22(25(43)38-20(6-4-12-35-27(31)32)23(41)26-34-14-15-46-26)40-24(42)21(7-5-13-36-28(33)44)39-29(45)37-17(3)18-8-10-19(30)11-9-18/h8-11,14-17,20-22H,4-7,12-13H2,1-3H3,(H,38,43)(H,40,42)(H4,31,32,35)(H3,33,36,44)(H2,37,39,45)/t17-,20+,21+,22+/m1/s1",BGBJLVHKOHYLME-MNAPGUCWSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.5,,IC50,,30.0,,,,,,18053726, coagulation factor XI,2360,P03951,Human,osocimab,11366,,,,,,Antibody,Inhibition,,,,,pKd,,8.62,,Kd,,2.4,,=,Binding affinity by SPR,,,31655039, coagulation factor XI,2360,P03951,Human,milvexian,11754,,118277544,C[C@@H]1CCC[C@@H](c2nccc(c2)c2c(cnn2C(F)F)NC1=O)n1cnc(cc1=O)c1c(ccc(c1)Cl)n1cc(nn1)Cl,"InChI=1S/C28H23Cl2F2N9O2/c1-15-3-2-4-23(20-9-16(7-8-33-20)26-21(36-27(15)43)12-35-41(26)28(31)32)39-14-34-19(11-25(39)42)18-10-17(29)5-6-22(18)40-13-24(30)37-38-40/h5-15,23,28H,2-4H2,1H3,(H,36,43)/t15-,23+/m1/s1",FSWFYCYPTDLKON-CMJOXMDJSA-N,Inhibitor,Inhibition,,,,,pKi,,9.96,,Ki,,0.11,,=,Assay using purified human F11a,,,34494428, coagulation factor XI,2360,P03951,Human,EP-7041,11990,,118291958,Nc1nccc(c1)C[C@@H]1[C@H](N(C1=O)C(=O)N[C@H](C)C1CCCCC1)C(=O)O,"InChI=1S/C19H26N4O4/c1-11(13-5-3-2-4-6-13)22-19(27)23-16(18(25)26)14(17(23)24)9-12-7-8-21-15(20)10-12/h7-8,10-11,13-14,16H,2-6,9H2,1H3,(H2,20,21)(H,22,27)(H,25,26)/t11-,14-,16+/m1/s1",NYPSZHLKEMYZKK-XFJVYGCCSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.15,,IC50,,7.1,,=,Inhibition of activated human factor XI (XIa),,,32984829, coagulation factor XI,2360,P03951,Human,FXIa inhibitor 3f,12133,,164607233,Clc1c(c(c(cc1)n1nnc(c1)Cl)c1ccc([n+](c1)[O-])[C@@H](CCOC(F)F)n1ncc(c1)c1cnnn1C)F,"InChI=1S/C23H18Cl2F3N9O2/c1-34-19(9-29-32-34)14-8-30-35(10-14)16(6-7-39-23(27)28)17-4-2-13(11-37(17)38)21-18(5-3-15(24)22(21)26)36-12-20(25)31-33-36/h2-5,8-12,16,23H,6-7H2,1H3/t16-/m1/s1",BETDGMHNHGHORO-MRXNPFEDSA-N,Inhibitor,Inhibition,,,,,pKi,,9.77,,Ki,,0.17,,=,Inhibition of purified human enzyme in vitro,,,35862732, coagulation factor XI,2360,P03951,Human,abelacimab,12417,,,,,,Antibody,Binding,,,,,pKd,,11.89,,Kd,,0.0013,,=,Binding to human FXI,,,30923107, coagulation factor XI,2360,P03951,Human,abelacimab,12417,,,,,,Antibody,Binding,,,,,pKd,,11.33,,Kd,,0.0047,,=,Binding to human FXIa,,,30923107,