target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id TANK binding kinase 1,2237,Q9UHD2,Human,amlexanox,7113,,2161,CC(c1ccc2c(c1)c(=O)c1c(o2)nc(c(c1)C(=O)O)N)C,"InChI=1S/C16H14N2O4/c1-7(2)8-3-4-12-9(5-8)13(19)10-6-11(16(20)21)14(17)18-15(10)22-12/h3-7H,1-2H3,(H2,17,18)(H,20,21)",SGRYPYWGNKJSDL-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,6.0,,5.7,IC50,2000.0,,1000.0,=,Inhibition of substrate phosphorylation.,,,23396211, TANK binding kinase 1,2237,Q9UHD2,Human,BX-795,8006,,10077147,O=C(N1CCCC1)Nc1cccc(c1)Nc1ncc(c(n1)NCCCNC(=O)c1cccs1)I,"InChI=1S/C23H26IN7O2S/c24-18-15-27-22(30-20(18)25-9-5-10-26-21(32)19-8-4-13-34-19)28-16-6-3-7-17(14-16)29-23(33)31-11-1-2-12-31/h3-4,6-8,13-15H,1-2,5,9-12H2,(H,26,32)(H,29,33)(H2,25,27,28,30)",VAVXGGRQQJZYBL-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.22,,IC50,,6.0,,=,,,,19307177, TANK binding kinase 1,2237,Q9UHD2,Human,MRT67307,8062,,44464263,O=C(C1CCC1)NCCCNc1nc(ncc1C1CC1)Nc1cccc(c1)CN1CCOCC1,"InChI=1S/C26H36N6O2/c33-25(21-5-2-6-21)28-11-3-10-27-24-23(20-8-9-20)17-29-26(31-24)30-22-7-1-4-19(16-22)18-32-12-14-34-15-13-32/h1,4,7,16-17,20-21H,2-3,5-6,8-15,18H2,(H,28,33)(H2,27,29,30,31)",UKBGBACORPRCGG-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.72,,IC50,,19.0,,=,,,,21138416, TANK binding kinase 1,2237,Q9UHD2,Human,compound 17d [PMID: 23099093],8196,,44465558,O=C(C1CCC1)NCCCNc1nc(ncc1C1CC1)Nc1ccc(cc1)N1CCOCC1,"InChI=1S/C25H34N6O2/c32-24(19-3-1-4-19)27-12-2-11-26-23-22(18-5-6-18)17-28-25(30-23)29-20-7-9-21(10-8-20)31-13-15-33-16-14-31/h7-10,17-19H,1-6,11-16H2,(H,27,32)(H2,26,28,29,30)",CJPMSUUANYLPET-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.22,,IC50,,6.0,,=,,,,23099093, TANK binding kinase 1,2237,Q9UHD2,Human,AZ13102909,9577,,126970684,COc1ccc(cc1)c1ccc(cc1)C1NC2C(=N1)C(=C(C=N2)C(=O)N)NNCCCNC(=O)C1CCCCC1,"InChI=1S/C30H37N7O3/c1-40-23-14-12-20(13-15-23)19-8-10-21(11-9-19)28-35-26-25(24(27(31)38)18-33-29(26)36-28)37-34-17-5-16-32-30(39)22-6-3-2-4-7-22/h8-15,18,22,28-29,34,36-37H,2-7,16-17H2,1H3,(H2,31,38)(H,32,39)",UMLDEMVOMRDOLS-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.3,,IC50,,5.0,,=,In vitro biochemical assay.,,,24962318, TANK binding kinase 1,2237,Q9UHD2,Human,SR8185,9578,,56646418,N#Cc1cc(ccc1N1CCCC1)c1ccnc(n1)Nc1cccc(c1)NC(=O)N1CCCC1,"InChI=1S/C26H27N7O/c27-18-20-16-19(8-9-24(20)32-12-1-2-13-32)23-10-11-28-25(31-23)29-21-6-5-7-22(17-21)30-26(34)33-14-3-4-15-33/h5-11,16-17H,1-4,12-15H2,(H,30,34)(H,28,29,31)",MQAQKNLCUSPSAF-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.0,,IC50,,10.0,,<,In an enzyme assay.,,,24150799, TANK binding kinase 1,2237,Q9UHD2,Human,compound II [PMID: 21329883],9579,,126970685,COc1ccc(cc1)N1N=CC2C1N=C(N=C2)Nc1cc(OC)c(c(c1)OCCCN1CCN(CC1)C)OC,"InChI=1S/C28H37N7O4/c1-33-11-13-34(14-12-33)10-5-15-39-25-17-21(16-24(37-3)26(25)38-4)31-28-29-18-20-19-30-35(27(20)32-28)22-6-8-23(36-2)9-7-22/h6-9,16-20,27H,5,10-15H2,1-4H3,(H,31,32)",DRSHXJFUUPIBHX-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.89,,IC50,,13.0,,=,In a biochemical assay using purified recombinant enzyme.,,,21329883, TANK binding kinase 1,2237,Q9UHD2,Human,MPI-0485520,9580,,56646218,N#Cc1cc(ccc1N1CCCC1)c1ccnc(n1)Nc1ccc2c(c1)CC(=O)N2,"InChI=1S/C23H20N6O/c24-14-17-11-15(3-6-21(17)29-9-1-2-10-29)20-7-8-25-23(28-20)26-18-4-5-19-16(12-18)13-22(30)27-19/h3-8,11-12H,1-2,9-10,13H2,(H,27,30)(H,25,26,28)",DHPSFJYFPJRCTN-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.7,,IC50,,2.0,,=,Using a Kinase Hotspot® assay.,,,, TANK binding kinase 1,2237,Q9UHD2,Human,GSK8612,10343,,137553174,Brc1cnc(nc1NCc1ccc(cc1)S(=O)(=O)N)Nc1cn(nc1C)CC(F)(F)F,"InChI=1S/C17H17BrF3N7O2S/c1-10-14(8-28(27-10)9-17(19,20)21)25-16-24-7-13(18)15(26-16)23-6-11-2-4-12(5-3-11)31(22,29)30/h2-5,7-8H,6,9H2,1H3,(H2,22,29,30)(H2,23,24,25,26)",FFPHMUIGESPOTK-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pKd,,8.0,,Kd,,10.0,,~,In a Kinobeads assay using lysates from HEK293/K-562/Placenta/HepG2 cells.,,,31097999, TANK binding kinase 1,2237,Q9UHD2,Human,BAY-985,10597,,145925685,O=C(N1CCN(CC1)[C@@H](c1ccnc(c1)Nc1nc2c([nH]1)cc(cc2)c1ncnc(c1)N(C)C)C)CC(F)(F)F,"InChI=1S/C27H30F3N9O/c1-17(38-8-10-39(11-9-38)25(40)15-27(28,29)30)18-6-7-31-23(13-18)36-26-34-20-5-4-19(12-22(20)35-26)21-14-24(37(2)3)33-16-32-21/h4-7,12-14,16-17H,8-11,15H2,1-3H3,(H2,31,34,35,36)/t17-/m1/s1",HZRJHVDNTDBTOZ-QGZVFWFLSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.7,,IC50,,2.0,,=,Inhibition at low ATP concentration.,,,31859507, TANK binding kinase 1,2237,Q9UHD2,Human,TBK1 PROTAC 3i,11661,,124108661,Cc1c(scn1)c1ccc(cc1)CNC(=O)[C@@H]1C[C@H](CN1C(=O)[C@H](C(C)(C)C)NC(=O)COCCCOCCCCOCCCOc1ccc(cc1)Nc1ncc(c(n1)NCCCN(C)C(=O)C1CCC1)Br)O,"InChI=1S/C53H74BrN9O9S/c1-36-46(73-35-58-36)38-16-14-37(15-17-38)31-56-49(66)44-30-41(64)33-63(44)51(68)47(53(2,3)4)60-45(65)34-71-28-10-26-69-24-6-7-25-70-27-11-29-72-42-20-18-40(19-21-42)59-52-57-32-43(54)48(61-52)55-22-9-23-62(5)50(67)39-12-8-13-39/h14-21,32,35,39,41,44,47,64H,6-13,22-31,33-34H2,1-5H3,(H,56,66)(H,60,65)(H2,55,57,59,61)/t41-,44+,47-/m1/s1",QMGHHBHPDDAGGO-IIWOMYBWSA-N,Inhibitor,Inhibition,,,,,pKd,,8.89,,Kd,,1.3,,=,BInding affinity for the TBK1 binding moeity of the PROTAC,,,28692295, TANK binding kinase 1,2237,Q9UHD2,Human,compound 6 [PMID: 34333981],11893,,145900912,NS(=O)(=O)c1ccc(CNc2nc(Nc3cccc(CN4CCOCC4)c3)ncc2Br)cc1,"InChI=1S/C22H25BrN6O3S/c23-20-14-26-22(27-18-3-1-2-17(12-18)15-29-8-10-32-11-9-29)28-21(20)25-13-16-4-6-19(7-5-16)33(24,30)31/h1-7,12,14H,8-11,13,15H2,(H2,24,30,31)(H2,25,26,27,28)",RDROKTFULACVDQ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.18,,IC50,,66.0,,=,,,,34333981,