target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id receptor interacting serine/threonine kinase 3,2191,Q9Y572,Human,ponatinib,5890,,24826799,CN1CCN(CC1)Cc1ccc(cc1C(F)(F)F)NC(=O)c1ccc(c(c1)C#Cc1cnc2n1nccc2)C,"InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)",PHXJVRSECIGDHY-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKi,,8.8,,Ki,,1.6,,=,Inhibition of recombinant RIPK3 in an in vitro ADP-Glo assay (Promega).,,,25801024, receptor interacting serine/threonine kinase 3,2191,Q9Y572,Human,RIPK1 inhibitor 22b,10155,,137321158,CCn1cc(c2c1ncnc2N)c1ccc2c(c1)CCN2C(=O)Cc1cccc(c1)OC(F)(F)F,"InChI=1S/C25H22F3N5O2/c1-2-32-13-19(22-23(29)30-14-31-24(22)32)16-6-7-20-17(12-16)8-9-33(20)21(34)11-15-4-3-5-18(10-15)35-25(26,27)28/h3-7,10,12-14H,2,8-9,11H2,1H3,(H2,29,30,31)",APPXQUDJLJXULP-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKd,,5.14,,Kd,,7200.0,,=,,,,30480444, receptor interacting serine/threonine kinase 3,2191,Q9Y572,Human,TAK-632,10387,,46209401,N#Cc1c(ccc2c1sc(n2)NC(=O)C1CC1)Oc1ccc(c(c1)NC(=O)Cc1cccc(c1)C(F)(F)F)F,"InChI=1S/C27H18F4N4O3S/c28-19-7-6-17(12-21(19)33-23(36)11-14-2-1-3-16(10-14)27(29,30)31)38-22-9-8-20-24(18(22)13-32)39-26(34-20)35-25(37)15-4-5-15/h1-3,6-10,12,15H,4-5,11H2,(H,33,36)(H,34,35,37)",OJFKUJDRGJSAQB-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKd,,6.98,,Kd,,105.0,,=,Binding constant determined by KINOMEscan assay.,,,30825190, receptor interacting serine/threonine kinase 3,2191,Q9Y572,Human,SZM594,10388,,138393290,O=C(Nc1cc(ccc1F)Oc1ccc2c(c1)sc(n2)NC(=O)C1CC1)Cc1cccc(c1)C(F)(F)F,"InChI=1S/C26H19F4N3O3S/c27-19-8-6-17(12-21(19)31-23(34)11-14-2-1-3-16(10-14)26(28,29)30)36-18-7-9-20-22(13-18)37-25(32-20)33-24(35)15-4-5-15/h1-3,6-10,12-13,15H,4-5,11H2,(H,31,34)(H,32,33,35)",SDSQERWTMKMZLA-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKd,,7.11,,Kd,,77.0,,=,Determined in a KINOMEscan assay.,,,30825190, receptor interacting serine/threonine kinase 3,2191,Q9Y572,Human,RIPK3 inhibitor 18,10389,,138393291,O=C(C1CC1)Nc1nccc(c1)Oc1ccc(c(c1C)C)NC(=O)c1cccn(c1=O)c1ccc(cc1)F,"InChI=1S/C29H25FN4O4/c1-17-18(2)25(38-22-13-14-31-26(16-22)33-27(35)19-5-6-19)12-11-24(17)32-28(36)23-4-3-15-34(29(23)37)21-9-7-20(30)8-10-21/h3-4,7-16,19H,5-6H2,1-2H3,(H,32,36)(H,31,33,35)",PETCZXAONWLUFT-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.04,,IC50,,9.1,,=,,,,, receptor interacting serine/threonine kinase 3,2191,Q9Y572,Human,RIPK3 inhibitor 42,10401,,138393293,O=C(Nc1cc(ccc1F)Oc1ccc2c(c1)sc(n2)NC(=O)C1CC1)Nc1cccc(c1)Br,"InChI=1S/C24H18BrFN4O3S/c25-14-2-1-3-15(10-14)27-23(32)28-20-11-16(6-8-18(20)26)33-17-7-9-19-21(12-17)34-24(29-19)30-22(31)13-4-5-13/h1-3,6-13H,4-5H2,(H2,27,28,32)(H,29,30,31)",RIVQMLWSKYAVFY-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pKd,,7.09,,Kd,,81.0,,=,,,,31095385, receptor interacting serine/threonine kinase 3,2191,Q9Y572,Human,SZM679,12311,,166176959,O=C(C1CC(=O)C1)Nc1nc2cc(F)c(Oc3ccc(F)c(NC(=O)Cc4cccc(OC(F)(F)F)c4)c3)cc2s1,"InChI=1S/C27H18F5N3O5S/c28-18-5-4-16(10-20(18)33-24(37)7-13-2-1-3-17(6-13)40-27(30,31)32)39-22-12-23-21(11-19(22)29)34-26(41-23)35-25(38)14-8-15(36)9-14/h1-6,10-12,14H,7-9H2,(H,33,37)(H,34,35,38)",OFQHMPFSITXRSS-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKd,,5.3,,Kd,,5000.0,,>,,,,36288088, receptor interacting serine/threonine kinase 3,2191,Q9Y572,Human,AZD5423,13017,,24825740,C[C@@H]([C@@H](C1=CC(=CC=C1)OC)OC2=CC3=C(C=C2)N(N=C3)C4=CC=C(C=C4)F)NC(=O)C(F)(F)F,"InChI=1S/C25H21F4N3O3/c1-15(31-24(33)25(27,28)29)23(16-4-3-5-20(12-16)34-2)35-21-10-11-22-17(13-21)14-30-32(22)19-8-6-18(26)7-9-19/h3-15,23H,1-2H3,(H,31,33)/t15-,23-/m0/s1",FCNQMDSJHADDFT-WNSKOXEYSA-N,Inhibitor,Inhibition,,,,,,,,,,,,,=,,,,36166972,