target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,pictilisib,5682,,17755052,CS(=O)(=O)N1CCN(CC1)Cc1cc2c(s1)c(nc(n2)c1cccc2c1cn[nH]2)N1CCOCC1,"InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27)",LHNIIDJUOCFXAP-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.52,,IC50,,3.0,,=,,,,18754654, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,pictilisib,5682,,17755052,CS(=O)(=O)N1CCN(CC1)Cc1cc2c(s1)c(nc(n2)c1cccc2c1cn[nH]2)N1CCOCC1,"InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27)",LHNIIDJUOCFXAP-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKi,,8.81,,Ki,,1.54,,=,,,,, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,PI-103,5701,,9884685,Oc1cccc(c1)c1nc(N2CCOCC2)c2c(n1)c1cccnc1o2,"InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2",TUVCWJQQGGETHL-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.52,,IC50,,3.0,,=,,,,19584227, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,TG-100-115,5715,,10427712,Oc1cccc(c1)c1nc2nc(N)nc(c2nc1c1cccc(c1)O)N,"InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24)",UJIAQDJKSXQLIT-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,6.63,,IC50,,235.0,,=,,,,17685602, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,LY 294002,6004,,3973,O=c1cc(oc2c1cccc2c1ccccc1)N1CCOCC1,"InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2",CZQHHVNHHHRRDU-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,6.66,,IC50,,220.0,,=,,,,23855836, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,LY 294002,6004,,3973,O=c1cc(oc2c1cccc2c1ccccc1)N1CCOCC1,"InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2",CZQHHVNHHHRRDU-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKd,,6.15,,Kd,,710.0,,=,,,,24533473, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,PI 3-Kg inhibitor,6023,,5289247,O=C1NC(=O)/C(=C/c2ccc3c(c2)nccn3)/S1,"InChI=1S/C12H7N3O2S/c16-11-10(18-12(17)15-11)6-7-1-2-8-9(5-7)14-4-3-13-8/h1-6H,(H,15,16,17)/b10-6-",SQWZFLMPDUSYGV-POHAHGRESA-N,Inhibitor,Inhibition,,,,,pIC50,,6.52,,IC50,,300.0,,=,,,,16127437, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,wortmannin,6060,,312145,COC[C@H]1OC(=O)c2c3[C@@]1(C)C1=C(C(=O)c3oc2)[C@H]2[C@@](C[C@H]1OC(=O)C)(C)C(=O)CC2,"InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1",QDLHCMPXEPAAMD-QAIWCSMKSA-N,Inhibitor,Inhibition,,,,,pKd,,8.26,,Kd,,5.5,,=,,,,30380865, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,idelalisib,6741,,11625818,CC[C@@H](c1nc2cccc(c2c(=O)n1c1ccccc1)F)Nc1ncnc2c1[nH]cn2,"InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1",IFSDAJWBUCMOAH-HNNXBMFYSA-N,Inhibitor,Inhibition,in vitro activity against recombinant enzyme,,yes,,pIC50,,8.6,,IC50,,2.5,,=,,,,20959606, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,izorlisib,7743,,49784945,Nc1ncc(cn1)c1nc(nc2c1CCN2S(=O)(=O)C)N1CCOCC1,"InChI=1S/C15H19N7O3S/c1-26(23,24)22-3-2-11-12(10-8-17-14(16)18-9-10)19-15(20-13(11)22)21-4-6-25-7-5-21/h8-9H,2-7H2,1H3,(H2,16,17,18)",JEGHXKRHKHPBJD-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.3,,IC50,,500.0,,=,,,,21316229, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,taselisib,7794,,51001932,Cc1nn(c(n1)c1cn2c(n1)c1ccc(cc1OCC2)c1cnn(c1)C(C(=O)N)(C)C)C(C)C,"InChI=1S/C24H28N8O2/c1-14(2)32-22(27-15(3)29-32)19-13-30-8-9-34-20-10-16(6-7-18(20)21(30)28-19)17-11-26-31(12-17)24(4,5)23(25)33/h6-7,10-14H,8-9H2,1-5H3,(H2,25,33)",BEUQXVWXFDOSAQ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKi,,10.1,,Ki,,0.079,,=,,,,, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,taselisib,7794,,51001932,Cc1nn(c(n1)c1cn2c(n1)c1ccc(cc1OCC2)c1cnn(c1)C(C(=O)N)(C)C)C(C)C,"InChI=1S/C24H28N8O2/c1-14(2)32-22(27-15(3)29-32)19-13-30-8-9-34-20-10-16(6-7-18(20)21(30)28-19)17-11-26-31(12-17)24(4,5)23(25)33/h6-7,10-14H,8-9H2,1-5H3,(H2,25,33)",BEUQXVWXFDOSAQ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pKi,,9.68,,Ki,,0.21,,=,,,,23662903, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,duvelisib,7795,,50905713,Clc1cccc2c1c(=O)n(c(c2)[C@@H](Nc1ncnc2c1[nH]cn2)C)c1ccccc1,"InChI=1S/C22H17ClN6O/c1-13(28-21-19-20(25-11-24-19)26-12-27-21)17-10-14-6-5-9-16(23)18(14)22(30)29(17)15-7-3-2-4-8-15/h2-13H,1H3,(H2,24,25,26,27,28)/t13-/m0/s1",SJVQHLPISAIATJ-ZDUSSCGKSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.6,,IC50,,2.5,,=,,,,24211136, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,copanlisib,7875,,135565596,COc1c(OCCCN2CCOCC2)ccc2c1nc(=NC(=O)c1cnc(nc1)N)n1c2NCC1,"InChI=1S/C23H28N8O4/c1-33-19-17(35-10-2-6-30-8-11-34-12-9-30)4-3-16-18(19)28-23(31-7-5-25-20(16)31)29-21(32)15-13-26-22(24)27-14-15/h3-4,13-14,25H,2,5-12H2,1H3,(H2,24,26,27)",MWYDSXOGIBMAET-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,9.15,,IC50,,0.7,,=,,,,24170767, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,apitolisib,7888,,25254071,O=C(N1CCN(CC1)Cc1sc2c(c1C)nc(nc2N1CCOCC1)c1cnc(nc1)N)[C@@H](O)C,"InChI=1S/C23H30N8O3S/c1-14-17(13-29-3-5-31(6-4-29)22(33)15(2)32)35-19-18(14)27-20(16-11-25-23(24)26-12-16)28-21(19)30-7-9-34-10-8-30/h11-12,15,32H,3-10,13H2,1-2H3,(H2,24,25,26)/t15-/m0/s1",YOVVNQKCSKSHKT-HNNXBMFYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.17,,IC50,,6.7,,=,,,,21981714, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,sapanisertib,7933,,45375953,Nc1oc2c(n1)cc(cc2)c1nn(c2c1c(N)ncn2)C(C)C,"InChI=1S/C15H15N7O/c1-7(2)22-14-11(13(16)18-6-19-14)12(21-22)8-3-4-10-9(5-8)20-15(17)23-10/h3-7H,1-2H3,(H2,17,20)(H2,16,18,19)",GYLDXIAOMVERTK-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.64,,IC50,,230.0,,=,,,,22367541, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,dactolisib,7950,,11977753,N#CC(c1ccc(cc1)n1c(=O)n(c2c1c1cc(ccc1nc2)c1cnc2c(c1)cccc2)C)(C)C,"InChI=1S/C30H23N5O/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36/h4-17H,1-3H3",JOGKUKXHTYWRGZ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.15,,IC50,,7.0,,=,,,,18606717, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,alpelisib,7955,,56649450,NC(=O)[C@@H]1CCCN1C(=O)Nc1nc(c(s1)c1ccnc(c1)C(C(F)(F)F)(C)C)C,"InChI=1S/C19H22F3N5O2S/c1-10-14(11-6-7-24-13(9-11)18(2,3)19(20,21)22)30-16(25-10)26-17(29)27-8-4-5-12(27)15(23)28/h6-7,9,12H,4-5,8H2,1-3H3,(H2,23,28)(H,25,26,29)/t12-/m0/s1",STUWGJZDJHPWGZ-LBPRGKRZSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.54,,IC50,,290.0,,=,,,,23726034, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,pilaralisib,7963,,1893730,Cc1ccc(cc1)S(=O)(=O)Nc1nc2ccccc2nc1Nc1ccc2c(c1)nsn2,"InChI=1S/C21H16N6O2S2/c1-13-6-9-15(10-7-13)31(28,29)27-21-20(23-16-4-2-3-5-17(16)24-21)22-14-8-11-18-19(12-14)26-30-25-18/h2-12H,1H3,(H,22,23)(H,24,27)",MQMKRQLTIWPEDM-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.44,,IC50,,36.0,,=,,,,, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,ZSTK474,7965,,11647372,FC(c1nc2c(n1c1nc(nc(n1)N1CCOCC1)N1CCOCC1)cccc2)F,"InChI=1S/C19H21F2N7O2/c20-15(21)16-22-13-3-1-2-4-14(13)28(16)19-24-17(26-5-9-29-10-6-26)23-18(25-19)27-7-11-30-12-8-27/h1-4,15H,5-12H2",HGVNLRPZOWWDKD-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,8.3,,8.22,IC50,6.0,,5.0,=,,,,16622124, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,KU-0060648,8011,,11964036,CCN1CCN(CC1)CC(=O)Nc1ccc(c2c1c1ccccc1s2)c1cccc2c1oc(cc2=O)N1CCOCC1,"InChI=1S/C33H34N4O4S/c1-2-35-12-14-36(15-13-35)21-29(39)34-26-11-10-23(33-31(26)25-6-3-4-9-28(25)42-33)22-7-5-8-24-27(38)20-30(41-32(22)24)37-16-18-40-19-17-37/h3-11,20H,2,12-19,21H2,1H3,(H,34,39)",AATCBLYHOUOCTO-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,10.0,,IC50,,0.1,,<,,,,23855836, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,PIK-75,8012,,10275789,Brc1ccc2n(c1)c(/C=N/N(S(=O)(=O)c1cc(ccc1C)[N+](=O)[O-])C)cn2,"InChI=1S/C16H14BrN5O4S/c1-11-3-5-13(22(23)24)7-15(11)27(25,26)20(2)19-9-14-8-18-16-6-4-12(17)10-21(14)16/h3-10H,1-2H3/b19-9+",QTHCAAFKVUWAFI-DJKKODMXSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.29,,IC50,,510.0,,=,,,,16647110, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,PP121,8013,,24905142,Nc1ncnc2c1c(nn2C1CCCC1)c1cnc2c(c1)cc[nH]2,"InChI=1S/C17H17N7/c18-15-13-14(11-7-10-5-6-19-16(10)20-8-11)23-24(12-3-1-2-4-12)17(13)22-9-21-15/h5-9,12H,1-4H2,(H,19,20)(H2,18,21,22)",NVRXTLZYXZNATH-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.82,,IC50,,150.0,,=,,,,18849971, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,AZD6482,8059,,44137675,Cc1cc([C@H](Nc2ccccc2C(=O)O)C)c2n(c1)c(=O)cc(n2)N1CCOCC1,"InChI=1S/C22H24N4O4/c1-14-11-17(15(2)23-18-6-4-3-5-16(18)22(28)29)21-24-19(12-20(27)26(21)13-14)25-7-9-30-10-8-25/h3-6,11-13,15,23H,7-10H2,1-2H3,(H,28,29)/t15-/m1/s1",IRTDIKMSKMREGO-OAHLLOKOSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.1,,IC50,,80.0,,=,,,,22906130, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,PI-3065,8242,,24937012,Fc1ccc2c(c1c1nc3cc(sc3c(n1)N1CCOCC1)CN1CCN(CC1)CC1CC1)cc[nH]2,"InChI=1S/C27H31FN6OS/c28-21-3-4-22-20(5-6-29-22)24(21)26-30-23-15-19(17-33-9-7-32(8-10-33)16-18-1-2-18)36-25(23)27(31-26)34-11-13-35-14-12-34/h3-6,15,18,29H,1-2,7-14,16-17H2",YDNOHCOYQVZOMC-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.82,,IC50,,15.0,,=,,,,24919154, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,TGX-221,8244,,9907093,Cc1cc(C(Nc2ccccc2)C)c2n(c1)c(=O)cc(n2)N1CCOCC1,"InChI=1S/C21H24N4O2/c1-15-12-18(16(2)22-17-6-4-3-5-7-17)21-23-19(13-20(26)25(21)14-15)24-8-10-27-11-9-24/h3-7,12-14,16,22H,8-11H2,1-2H3",CPRAGQJXBLMUEL-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.0,,IC50,,100.0,,=,,,,15834429, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,VS-5584,8382,,46912230,Nc1ncc(cn1)c1nc(nc2c1nc(n2C(C)C)C)N1CCOCC1,"InChI=1S/C17H22N8O/c1-10(2)25-11(3)21-14-13(12-8-19-16(18)20-9-12)22-17(23-15(14)25)24-4-6-26-7-5-24/h8-10H,4-7H2,1-3H3,(H2,18,19,20)",QYBGBLQCOOISAR-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.38,,IC50,,42.0,,=,,,,23270925, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,bimiralisib,8383,,58507717,Nc1ncc(c(c1)C(F)(F)F)c1nc(nc(n1)N1CCOCC1)N1CCOCC1,"InChI=1S/C17H20F3N7O2/c18-17(19,20)12-9-13(21)22-10-11(12)14-23-15(26-1-5-28-6-2-26)25-16(24-14)27-3-7-29-8-4-27/h9-10H,1-8H2,(H2,21,22)",ADGGYDAFIHSYFI-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pKd,,7.6,,Kd,,25.0,,=,,,,, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,AZD8186,8527,,52913813,Fc1cc(cc(c1)F)N[C@@H](c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C)C,"InChI=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3)9-20-21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3/t14-/m1/s1",LMJFJIDLEAWOQJ-CQSZACIVSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.92,,IC50,,12.0,,=,,,,25398829, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,SAR260301,8793,,135565159,C[C@H]1Cc2c(N1C(=O)Cc1nc(=O)cc([nH]1)N1CCOCC1)cccc2,"InChI=1S/C19H22N4O3/c1-13-10-14-4-2-3-5-15(14)23(13)19(25)11-16-20-17(12-18(24)21-16)22-6-8-26-9-7-22/h2-5,12-13H,6-11H2,1H3,(H,20,21,24)/t13-/m0/s1",UAXHPOBBKRWJGA-ZDUSSCGKSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.33,,IC50,,468.0,,=,,,,24387221, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,compound 82 [PMID: 21332118],8805,,50990924,CC(=O)Nc1nc2c(s1)cc(cc2)c1cnc(c(c1)NS(=O)(=O)c1ccc(cc1)F)Cl,"InChI=1S/C20H14ClFN4O3S2/c1-11(27)24-20-25-16-7-2-12(9-18(16)30-20)13-8-17(19(21)23-10-13)26-31(28,29)15-5-3-14(22)4-6-15/h2-10,26H,1H3,(H,24,25,27)",YGBMCLDVRUGXOV-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKi,,8.92,,Ki,,1.2,,=,,,,21332118, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,torin 2,8839,,51358113,Nc1ccc(cn1)c1ccc2c(c1)c1c(cn2)ccc(=O)n1c1cccc(c1)C(F)(F)F,"InChI=1S/C24H15F3N4O/c25-24(26,27)17-2-1-3-18(11-17)31-22(32)9-6-16-13-29-20-7-4-14(10-19(20)23(16)31)15-5-8-21(28)30-12-15/h1-13H,(H2,28,30)",GUXXEUUYCAYESJ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.25,,IC50,,5.67,,=,,,,21322566, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,AZD8835,8915,,76685059,OCCC(=O)N1CCC(CC1)c1nn(c(n1)c1cnc(c(n1)c1nnc(o1)C(C)(C)C)N)CC,"InChI=1S/C22H31N9O3/c1-5-31-19(26-18(29-31)13-6-9-30(10-7-13)15(33)8-11-32)14-12-24-17(23)16(25-14)20-27-28-21(34-20)22(2,3)4/h12-13,32H,5-11H2,1-4H3,(H2,23,24)",ZGRDYKFVDCFJCZ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.24,,IC50,,5.7,,=,,,,26475521, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,umbralisib,8916,,72950888,CC(Oc1ccc(cc1F)c1nn(c2c1c(N)ncn2)[C@H](c1oc2ccc(cc2c(=O)c1c1cccc(c1)F)F)C)C,"InChI=1S/C31H24F3N5O3/c1-15(2)41-24-9-7-18(12-22(24)34)27-26-30(35)36-14-37-31(26)39(38-27)16(3)29-25(17-5-4-6-19(32)11-17)28(40)21-13-20(33)8-10-23(21)42-29/h4-16H,1-3H3,(H2,35,36,37)/t16-/m0/s1",IUVCFHHAEHNCFT-INIZCTEOSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.86,,IC50,,13.83,,=,,,,, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,AMG319,8917,,68947304,Fc1ccc2c(c1)nc(c(c2)[C@@H](Nc1ncnc2c1[nH]cn2)C)c1ccccn1,"InChI=1S/C21H16FN7/c1-12(28-21-19-20(25-10-24-19)26-11-27-21)15-8-13-5-6-14(22)9-17(13)29-18(15)16-4-2-3-7-23-16/h2-12H,1H3,(H2,24,25,26,27,28)/t12-/m0/s1",KWRYMZHCQIOOEB-LBPRGKRZSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.74,,IC50,,18.0,,=,,,,25469863, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,samotolisib,8918,,57519748,CO[C@H](Cn1c(=O)n(c2c1c1cc(ccc1nc2)c1cncc(c1)C(O)(C)C)C)C,"InChI=1S/C23H26N4O3/c1-14(30-5)13-27-21-18-9-15(16-8-17(11-24-10-16)23(2,3)29)6-7-19(18)25-12-20(21)26(4)22(27)28/h6-12,14,29H,13H2,1-5H3/t14-/m0/s1",ACCFLVVUVBJNGT-AWEZNQCLSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.42,,IC50,,38.0,,=,,,,, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,fimepinostat,8952,,54575456,ONC(=O)c1cnc(nc1)N(Cc1cc2c(s1)c(nc(n2)c1ccc(nc1)OC)N1CCOCC1)C,"InChI=1S/C23H24N8O4S/c1-30(23-25-11-15(12-26-23)22(32)29-33)13-16-9-17-19(36-16)21(31-5-7-35-8-6-31)28-20(27-17)14-3-4-18(34-2)24-10-14/h3-4,9-12,33H,5-8,13H2,1-2H3,(H,29,32)",JOWXJLIFIIOYMS-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.41,,IC50,,39.0,,=,,,,22693356, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,PIK-108,8968,,54751698,Cc1cc([C@@H](Nc2ccccc2)C)c2c(c1)c(=O)cc(o2)N1CCOCC1,"InChI=1S/C22H24N2O3/c1-15-12-18(16(2)23-17-6-4-3-5-7-17)22-19(13-15)20(25)14-21(27-22)24-8-10-26-11-9-24/h3-7,12-14,16,23H,8-11H2,1-2H3/t16-/m0/s1",VRCXIJAYLCUSHC-INIZCTEOSA-N,Allosteric modulator,Negative,,,,,pIC50,,6.18,,IC50,,658.0,,=,,,,22524426, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,serabelisib,8969,,70798655,Nc1oc2c(n1)cc(cc2)c1ccc2n(c1)c(cn2)C(=O)N1CCOCC1,"InChI=1S/C19H17N5O3/c20-19-22-14-9-12(1-3-16(14)27-19)13-2-4-17-21-10-15(24(17)11-13)18(25)23-5-7-26-8-6-23/h1-4,9-11H,5-8H2,(H2,20,22)",BLGWHBSBBJNKJO-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,5.0,,IC50,,10000.0,,<,,,,, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,omipalisib,8974,,25167777,COc1ncc(cc1NS(=O)(=O)c1ccc(cc1F)F)c1ccc2c(c1)c(ccn2)c1ccnnc1,"InChI=1S/C25H17F2N5O3S/c1-35-25-23(32-36(33,34)24-5-3-18(26)12-21(24)27)11-17(13-29-25)15-2-4-22-20(10-15)19(7-8-28-22)16-6-9-30-31-14-16/h2-14,32H,1H3",CGBJSGAELGCMKE-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKi,,7.22,,Ki,,60.0,,=,,,,24900173, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,IC-87114,9376,,9908783,Nc1ncnc2c1ncn2Cc1nc2cccc(c2c(=O)n1c1ccccc1C)C,"InChI=1S/C22H19N7O/c1-13-6-3-4-9-16(13)29-17(27-15-8-5-7-14(2)18(15)22(29)30)10-28-12-26-19-20(23)24-11-25-21(19)28/h3-9,11-12H,10H2,1-2H3,(H2,23,24,25)",GNWHRHGTIBRNSM-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.3,,IC50,,500.0,,=,,,,12594293, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,IC-87114,9376,,9908783,Nc1ncnc2c1ncn2Cc1nc2cccc(c2c(=O)n1c1ccccc1C)C,"InChI=1S/C22H19N7O/c1-13-6-3-4-9-16(13)29-17(27-15-8-5-7-14(2)18(15)22(29)30)10-28-12-26-19-20(23)24-11-25-21(19)28/h3-9,11-12H,10H2,1-2H3,(H2,23,24,25)",GNWHRHGTIBRNSM-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKi,,7.7,,Ki,,20.0,,~,,,,15975507, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,leniolisib,9424,,57495353,CCC(=O)N1CC[C@@H](C1)Nc1ncnc2c1CN(CC2)c1cnc(c(c1)C(F)(F)F)OC,"InChI=1S/C21H25F3N6O2/c1-3-18(31)30-6-4-13(10-30)28-19-15-11-29(7-5-17(15)26-12-27-19)14-8-16(21(22,23)24)20(32-2)25-9-14/h8-9,12-13H,3-7,10-11H2,1-2H3,(H,26,27,28)/t13-/m0/s1",MWKYMZXCGYXLPL-ZDUSSCGKSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.64,,IC50,,23.0,,=,In vitro enzyme assay,,,, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,nemiralisib,9425,,49784002,CC(N1CCN(CC1)Cc1cnc(o1)c1cc(cc2c1cn[nH]2)c1cccc2c1cc[nH]2)C,"InChI=1S/C26H28N6O/c1-17(2)32-10-8-31(9-11-32)16-19-14-28-26(33-19)22-12-18(13-25-23(22)15-29-30-25)20-4-3-5-24-21(20)6-7-27-24/h3-7,12-15,17,27H,8-11,16H2,1-2H3,(H,29,30)",MCIDWGZGWVSZMK-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,9.9,,IC50,,0.126,,=,In a homogeneous time-resolved fluorescence (HTRF) assay in the presence of 2mM ATP.,,,26301626, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,eganelisib,9563,,91933883,Cn1ncc(c1)C#Cc1cccc2c1c(=O)n(c(c2)[C@@H](NC(=O)c1c(N)nn2c1nccc2)C)c1ccccc1,"InChI=1S/C30H24N8O2/c1-19(34-29(39)26-27(31)35-37-15-7-14-32-28(26)37)24-16-22-9-6-8-21(13-12-20-17-33-36(2)18-20)25(22)30(40)38(24)23-10-4-3-5-11-23/h3-11,14-19H,1-2H3,(H2,31,35)(H,34,39)/t19-/m0/s1",XUMALORDVCFWKV-IBGZPJMESA-N,Inhibitor,Inhibition,,,,,pKd,,7.64,,Kd,,23.0,,=,,,,27660692, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,eCF309,9571,,122163152,CCOC(Cn1nc(c2c1ncnc2N)c1ccc2c(c1)nc(o2)N)OCC,"InChI=1S/C18H21N7O3/c1-3-26-13(27-4-2)8-25-17-14(16(19)21-9-22-17)15(24-25)10-5-6-12-11(7-10)23-18(20)28-12/h5-7,9,13H,3-4,8H2,1-2H3,(H2,20,23)(H2,19,21,22)",PSICWGWNIOOULV-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,5.74,,IC50,,1840.0,,=,In a biochemical assay.,,,, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,inavolisib,9636,,124173720,NC(=O)[C@@H](Nc1ccc2c(c1)OCCn1c2nc(c1)N1C(=O)OC[C@H]1C(F)F)C,"InChI=1S/C18H19F2N5O4/c1-9(16(21)26)22-10-2-3-11-13(6-10)28-5-4-24-7-14(23-17(11)24)25-12(15(19)20)8-29-18(25)27/h2-3,6-7,9,12,15,22H,4-5,8H2,1H3,(H2,21,26)/t9-,12-/m0/s1",SGEUNORSOZVTOL-CABZTGNLSA-N,Inhibitor,Inhibition,,,,,pKi,,7.91,,Ki,,12.2,,=,,,,, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,STK16-IN-1,9692,,58525066,Fc1ccc(cc1C)n1c(=O)ccc2c1c1cc[nH]c1nc2,"InChI=1S/C17H12FN3O/c1-10-8-12(3-4-14(10)18)21-15(22)5-2-11-9-20-17-13(16(11)21)6-7-19-17/h2-9H,1H3,(H,19,20)",WQNRDXHKVSKUPI-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.07,,IC50,,856.0,,=,In an in vitro enzymatic assay.,,,27082499, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,dezapelisib,9728,,58111426,Fc1cccc(c1)c1c(nc2n(c1=O)c(C)cs2)[C@@H](Nc1ncnc2c1nc[nH]2)C,"InChI=1S/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)/t11-/m0/s1",RSIWALKZYXPAGW-NSHDSACASA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.3,,IC50,,50.0,,<,The same value was obtained using an enzyme activity assay and a scintillation proximity assay.,,,, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,seletalisib,9800,,56928390,[O-][n+]1cccc(c1)c1nc2c(cc1[C@H](C(F)(F)F)Nc1ncnc3c1nccc3)cccc2Cl,"InChI=1S/C23H14ClF3N6O/c24-16-6-1-4-13-10-15(18(31-19(13)16)14-5-3-9-33(34)11-14)21(23(25,26)27)32-22-20-17(29-12-30-22)7-2-8-28-20/h1-12,21H,(H,29,30,32)/t21-/m1/s1",LNLJHGXOFYUARS-OAQYLSRUSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.92,,IC50,,12.0,,=,,,,28442583, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,tenalisib,9907,,86291103,CC[C@@H](c1oc2ccccc2c(=O)c1c1cccc(c1)F)Nc1ncnc2c1[nH]cn2,"InChI=1S/C23H18FN5O2/c1-2-16(29-23-19-22(26-11-25-19)27-12-28-23)21-18(13-6-5-7-14(24)10-13)20(30)15-8-3-4-9-17(15)31-21/h3-12,16H,2H2,1H3,(H2,25,26,27,28,29)/t16-/m0/s1",HDXDQPRPFRKGKZ-INIZCTEOSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.62,,IC50,,24.05,,=,In a high throughput biochemical assay.,,,, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,panulisib,9916,,56947515,N#CN=c1n(c2ccc(nc2)C(C#N)(C)C)c2c(n1C)cnc1c2cc(cc1)c1cnc(c(c1)C(F)(F)F)N,"InChI=1S/C27H20F3N9/c1-26(2,13-31)22-7-5-17(11-35-22)39-23-18-8-15(16-9-19(27(28,29)30)24(33)36-10-16)4-6-20(18)34-12-21(23)38(3)25(39)37-14-32/h4-12H,1-3H3,(H2,33,36)",VJLRLTSXTLICIR-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.4,,IC50,,4.0,,=,Using a radiometric protein kinase (33PanQinase activity) assay.,,,25700704, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,puquitinib,9928,,15983184,c1cnc2c(c1)cc(cc2)Nc1nc(NC2CC2)c2c(n1)nc[nH]2,"InChI=1S/C17H15N7/c1-2-10-8-12(5-6-13(10)18-7-1)22-17-23-15-14(19-9-20-15)16(24-17)21-11-3-4-11/h1-2,5-9,11H,3-4H2,(H3,19,20,21,22,23,24)",QUTFBURLXCODBH-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.48,,IC50,,3.3,,=,,,,28418085, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,compound 20f [PMID: 28520415],9961,,134611885,N#Cc1c(ncnc1N)N[C@H](c1cc2scc(n2c(=O)c1c1cccc(c1)CN1CCC(CC1)N(CC(C)C)C)C)C,"InChI=1S/C32H40N8OS/c1-20(2)16-38(5)25-9-11-39(12-10-25)17-23-7-6-8-24(13-23)29-26(14-28-40(32(29)41)21(3)18-42-28)22(4)37-31-27(15-33)30(34)35-19-36-31/h6-8,13-14,18-20,22,25H,9-12,16-17H2,1-5H3,(H3,34,35,36,37)/t22-/m0/s1",ZUQSHQGUCXJKSV-QFIPXVFZSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,9.2,,IC50,,0.63,,=,,,,28520415, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,AZD3458,9997,,134611894,CC(=O)Nc1sc(c(n1)C)c1cc2CN(C(=O)c2c(c1)S(=O)(=O)C)[C@H](C1CC1)C,"InChI=1S/C20H23N3O4S2/c1-10-18(28-20(21-10)22-12(3)24)14-7-15-9-23(11(2)13-5-6-13)19(25)17(15)16(8-14)29(4,26)27/h7-8,11,13H,5-6,9H2,1-4H3,(H,21,22,24)/t11-/m0/s1",PAQUFWFUOVDUIO-NSHDSACASA-N,Inhibitor,Inhibition,,,,,pIC50,,6.5,,IC50,,316.0,,=,In a biochemical enzyme activity assay.,,,29852070, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,compound 52 [PMID: 28541707],10001,,132220479,N#Cc1ccc(cc1N1CCN(C(C1=O)(C)C)C(=O)C)c1cc(c2n1ncnc2N)C(F)(F)F,"InChI=1S/C22H20F3N7O2/c1-12(33)31-7-6-30(20(34)21(31,2)3)16-8-13(4-5-14(16)10-26)17-9-15(22(23,24)25)18-19(27)28-11-29-32(17)18/h4-5,8-9,11H,6-7H2,1-3H3,(H2,27,28,29)",ZDXIDBRGTYDHBQ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.77,,IC50,,1.7,,=,,,,28541707, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,acalisib,10096,,11618268,Fc1ccc2c(c1)c(=O)n(c(n2)[C@@H](Nc1ncnc2c1[nH]cn2)C)c1ccccc1,"InChI=1S/C21H16FN7O/c1-12(27-19-17-18(24-10-23-17)25-11-26-19)20-28-16-8-7-13(22)9-15(16)21(30)29(20)14-5-3-2-4-6-14/h2-12H,1H3,(H2,23,24,25,26,27)/t12-/m0/s1",DOCINCLJNAXZQF-LBPRGKRZSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.9,,IC50,,12.7,,=,In an in vitro biochemical assay using recombinant enzyme.,,,24133210, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,parsaclisib,10098,,89420683,CCOc1c(C2CNC(=O)C2)c(F)c(cc1[C@@H](n1nc(c2c1ncnc2N)C)C)Cl,"InChI=1S/C20H22ClFN6O2/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26)/t10-,11?/m0/s1",ZQPDJCIXJHUERQ-VUWPPUDQSA-N,Inhibitor,Inhibition,,,,,pIC50,8.0,,7.3,IC50,50.0,,10.0,=,,,,, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,neolymphostin A,10151,,137321157,CO/C=C/C(=O)c1cc2C=Nc3c2c(n1)c(NC(=O)C(C)C)cc3N,"InChI=1S/C18H18N4O3/c1-9(2)18(24)22-13-7-11(19)16-15-10(8-20-16)6-12(21-17(13)15)14(23)4-5-25-3/h4-9H,19H2,1-3H3,(H,22,24)/b5-4+",OKZVXALNOKYCRL-SNAWJCMRSA-N,Inhibitor,Inhibition,,,,,pKd,,8.31,,Kd,,4.9,,=,Determined using an active-site dependent competition binding assay.,,,30380865, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,RV1729,10162,,52913198,COCCN(C(=O)CCCC#Cc1cccc2c1c(=O)n(c(n2)Cn1nc(c2c1ncnc2N)c1cccc(c1)O)Cc1ccccc1Cl)CCOC,"InChI=1S/C39H39ClN8O5/c1-52-20-18-46(19-21-53-2)33(50)17-5-3-4-10-26-12-9-16-31-34(26)39(51)47(23-28-11-6-7-15-30(28)40)32(44-31)24-48-38-35(37(41)42-25-43-38)36(45-48)27-13-8-14-29(49)22-27/h6-9,11-16,22,25,49H,3,5,17-21,23-24H2,1-2H3,(H2,41,42,43)",UBLOHCIYTDRGJH-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.92,,IC50,,12.0,,=,In a biochemical enzyme activity assay.,,,, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,RV6153,10163,,86268622,COCCOCCOCC#Cc1cccc2c1c(=O)n(c(n2)Cn1nc(c2c1ncnc2N)c1cc(O)cc(c1)F)Cc1ccccc1C(F)(F)F,"InChI=1S/C36H31F4N7O5/c1-50-12-13-52-15-14-51-11-5-8-22-7-4-10-28-30(22)35(49)46(19-23-6-2-3-9-27(23)36(38,39)40)29(44-28)20-47-34-31(33(41)42-21-43-34)32(45-47)24-16-25(37)18-26(48)17-24/h2-4,6-7,9-10,16-18,21,48H,11-15,19-20H2,1H3,(H2,41,42,43)",JTACVHJPXOKMTI-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.6,,IC50,,2.5,,=,In a biochemical enzyme activity assay.,,,, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,AZ2,10233,,134163708,CC(=O)Nc1sc(c(n1)C)c1cc(C)c2c(c1)CN(C2=O)[C@H](C1CC1)C,"InChI=1S/C20H23N3O2S/c1-10-7-15(18-11(2)21-20(26-18)22-13(4)24)8-16-9-23(19(25)17(10)16)12(3)14-5-6-14/h7-8,12,14H,5-6,9H2,1-4H3,(H,21,22,24)/t12-/m0/s1",CNCRCDLWUGCPSJ-LBPRGKRZSA-N,Inhibitor,Inhibition,,,,,pKi,,6.7,,Ki,,199.0,,=,,,,30718815, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,compound 2q [PMID: 30986068],10365,,118556943,CCn1ncc(c1C)c1nc2c(n1C)ncnc2O[C@H]1CCN(C1)C(=O)C1CCOCC1,"InChI=1S/C22H29N7O3/c1-4-29-14(2)17(11-25-29)19-26-18-20(27(19)3)23-13-24-21(18)32-16-5-8-28(12-16)22(30)15-6-9-31-10-7-15/h11,13,15-16H,4-10,12H2,1-3H3/t16-/m0/s1",FHKPLLOSJHHKNU-INIZCTEOSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.41,,IC50,,3.9,,=,"In a biochemical HTRF assay measuring generation of PIP3 via phosphorylation of PIP2, using PI3Kδ 14-604 fragment.",,,30986068, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,compound 5d [PMID: 31335136],10441,,135197617,COc1ncc(cc1NS(=O)(=O)c1ccc(cc1F)F)c1cc(OCC2(C)COC2)c2c(c1)c(C)ncn2,"InChI=1S/C26H24F2N4O5S/c1-15-19-6-16(8-22(24(19)31-14-30-15)37-13-26(2)11-36-12-26)17-7-21(25(35-3)29-10-17)32-38(33,34)23-5-4-18(27)9-20(23)28/h4-10,14,32H,11-13H2,1-3H3",CPUXOJVJEJZOSP-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.96,,IC50,,1.1,,=,,,,31335136, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,linperlisib,10466,,91754520,COc1ncc(cc1NS(=O)(=O)C)c1nc(nc2c1cc(F)cc2CN1CCC(CC1)C(O)(C)C)N1CCOCC1,"InChI=1S/C28H37FN6O5S/c1-28(2,36)20-5-7-34(8-6-20)17-19-13-21(29)15-22-24(31-27(32-25(19)22)35-9-11-40-12-10-35)18-14-23(33-41(4,37)38)26(39-3)30-16-18/h13-16,20,33,36H,5-12,17H2,1-4H3",NVWKNQGHVMMAJW-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.62,,IC50,,2.4,,=,Measured in a luminescence assay to detect modulation of ADP formation in the presence of test compound and hPI3Kδ.,,,, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,compound 41 [PMID: 31855425],10598,,145946093,COCCS(=O)(=O)Nc1cc(cnc1OC)c1cc(OC[C@@H]2OCCN(C2)C2COC2)c2c(c1)COC2,"InChI=1S/C25H33N3O8S/c1-31-5-6-37(29,30)27-23-8-18(10-26-25(23)32-2)17-7-19-12-33-16-22(19)24(9-17)36-15-21-11-28(3-4-35-21)20-13-34-14-20/h7-10,20-21,27H,3-6,11-16H2,1-2H3/t21-/m1/s1",ZWPJBXLFZFLGMV-OAQYLSRUSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.2,,IC50,,6.31,,=,,,,31855425, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,compound 41 [PMID: 31855425],10598,,145946093,COCCS(=O)(=O)Nc1cc(cnc1OC)c1cc(OC[C@@H]2OCCN(C2)C2COC2)c2c(c1)COC2,"InChI=1S/C25H33N3O8S/c1-31-5-6-37(29,30)27-23-8-18(10-26-25(23)32-2)17-7-19-12-33-16-22(19)24(9-17)36-15-21-11-28(3-4-35-21)20-13-34-14-20/h7-10,20-21,27H,3-6,11-16H2,1-2H3/t21-/m1/s1",ZWPJBXLFZFLGMV-OAQYLSRUSA-N,Inhibitor,Inhibition,,,,,pKd,,9.7,,Kd,,0.2,,=,Apparent binding affinity determined using the lipid kinobead assay.,,,31855425, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,zandelisib,10627,,66571003,CN1CCC(CC1)c1ccccc1CC(Nc1nc(nc(n1)n1c(nc2c1cccc2)C(F)F)N1CCOCC1)(C)C,"InChI=1S/C31H38F2N8O/c1-31(2,20-22-8-4-5-9-23(22)21-12-14-39(3)15-13-21)38-28-35-29(40-16-18-42-19-17-40)37-30(36-28)41-25-11-7-6-10-24(25)34-27(41)26(32)33/h4-11,21,26H,12-20H2,1-3H3,(H,35,36,37,38)",WPFUFWIHMYZXSF-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.0,,IC50,,100.0,,<,,,,, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,GSK2292767,10633,,49783923,COc1ncc(cc1NS(=O)(=O)C)c1cc(c2ncc(o2)CN2C[C@H](C)O[C@@H](C2)C)c2c(c1)[nH]nc2,"InChI=1S/C24H28N6O5S/c1-14-11-30(12-15(2)34-14)13-18-9-26-23(35-18)19-5-16(6-21-20(19)10-27-28-21)17-7-22(29-36(4,31)32)24(33-3)25-8-17/h5-10,14-15,29H,11-13H2,1-4H3,(H,27,28)/t14-,15+",NLUPPCTVKHDVIQ-GASCZTMLSA-N,Inhibitor,Inhibition,,,,,pKi,,10.1,,Ki,,0.08,,=,,,,30532965, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,compound 7 [PMID: 31955578],10649,,145996536,C[C@@H]1COCCN1c1nc(nc2c1nc(s2)c1n[nH]cc1)N1CCOC[C@@H]1C,"InChI=1S/C18H23N7O2S/c1-11-9-26-7-5-24(11)15-14-17(28-16(20-14)13-3-4-19-23-13)22-18(21-15)25-6-8-27-10-12(25)2/h3-4,11-12H,5-10H2,1-2H3,(H,19,23)/t11-,12+/m1/s1",ZJXHODMMACVLQQ-NEPJUHHUSA-N,Inhibitor,Inhibition,,,,,pIC50,,5.77,,IC50,,1700.0,,=,,,,31955578, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,compound 15a [PMID: 32069401],10702,,145996540,COc1ncc(cc1NS(=O)(=O)c1ccc(cc1F)F)c1ccc2n(c1)c(cn2)c1nnc(o1)CCN1CCN(CC1)C,"InChI=1S/C28H28F2N8O4S/c1-36-9-11-37(12-10-36)8-7-26-33-34-28(42-26)23-16-31-25-6-3-18(17-38(23)25)19-13-22(27(41-2)32-15-19)35-43(39,40)24-5-4-20(29)14-21(24)30/h3-6,13-17,35H,7-12H2,1-2H3",LSPJWTULWKYRTQ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,9.3,,IC50,,0.5,,=,,,,32069401, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,AZD8154,11204,,141754136,C[C@H](N1Cc2c(C1=O)c(cc(c2)c1sc(nc1C)Nc1cccc(n1)N1CCCC1=O)S(=O)(=O)C)C1CC1,"InChI=1S/C27H29N5O4S2/c1-15-25(37-27(28-15)30-21-6-4-7-22(29-21)31-11-5-8-23(31)33)18-12-19-14-32(16(2)17-9-10-17)26(34)24(19)20(13-18)38(3,35)36/h4,6-7,12-13,16-17H,5,8-11,14H2,1-3H3,(H,28,29,30)/t16-/m0/s1",XOMFDZJQLSPGGV-INIZCTEOSA-N,Inhibitor,Inhibition,,,,,pIC50,,9.15,,IC50,,0.7,,=,,,,, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,amdizalisib,11699,,118981804,C[C@@H](c1cc2ncc(n2nc1c1ccccc1)Cl)Nc1ncnc(c1C#N)N,"InChI=1S/C19H15ClN8/c1-11(26-19-14(8-21)18(22)24-10-25-19)13-7-16-23-9-15(20)28(16)27-17(13)12-5-3-2-4-6-12/h2-7,9-11H,1H3,(H3,22,24,25,26)/t11-/m0/s1",WKDBRCUUDXLTIM-NSHDSACASA-N,Inhibitor,Inhibition,,,,,pIC50,,9.52,,IC50,,0.3,,=,,,,, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,compound 27 [PMID: 35834807],12062,,164886635,Nc1nc2cc(c3nc(N4CCOCC4)nc(N4CCOCC4)n3)ccc2o1,"InChI=1S/C18H21N7O3/c19-16-20-13-11-12(1-2-14(13)28-16)15-21-17(24-3-7-26-8-4-24)23-18(22-15)25-5-9-27-10-6-25/h1-2,11H,3-10H2,(H2,19,20)",LOQNSAZUXOBMAX-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.82,,IC50,,153.0,,=,,,,35834807, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,vulolisib,12075,,146267141,C[C@H](Nc1cc2c(cc1)c1nc(cn1CCO2)N1[C@@H](CSC1=O)C(F)F)C(=O)N,"InChI=1S/C18H19F2N5O3S/c1-9(16(21)26)22-10-2-3-11-13(6-10)28-5-4-24-7-14(23-17(11)24)25-12(15(19)20)8-29-18(25)27/h2-3,6-7,9,12,15,22H,4-5,8H2,1H3,(H2,21,26)/t9-,12-/m0/s1",KEEKMOIRJUWKNK-CABZTGNLSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.31,,IC50,,49.0,,=,,,,, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,NVP-CLR457,12119,,71682837,Nc1ncc(c(n1)C(F)(F)F)c1nc(N2CCOCC2)nc(N2[C@@H](CO)[C@@H](C)OC2=O)c1,"InChI=1S/C18H20F3N7O4/c1-9-12(8-29)28(17(30)32-9)13-6-11(24-16(25-13)27-2-4-31-5-3-27)10-7-23-15(22)26-14(10)18(19,20)21/h6-7,9,12,29H,2-5,8H2,1H3,(H2,22,23,26)/t9-,12+/m1/s1",IEYOHYVYEJVEJJ-SKDRFNHKSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.64,,IC50,,230.0,,=,,,,35500094, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,roginolisib,12487,,66580799,FC1=CC=CC2=C1S(=O)(=O)CC3=C2N(N=C3C(=O)N4CCOCC4)C5=CC=C(CN6CCOCC6)C=C5,"InChI=1S/C26H27FN4O5S/c27-22-3-1-2-20-24-21(17-37(33,34)25(20)22)23(26(32)30-10-14-36-15-11-30)28-31(24)19-6-4-18(5-7-19)16-29-8-12-35-13-9-29/h1-7H,8-17H2",NFHSJYKXENYICE-UHFFFAOYSA-N,Allosteric modulator,Inhibition,,,,,pIC50,,6.46,,IC50,,347.0,,=,Inhibitory efficacy determined by Scintillation Proximity Assay detecting phosphorylated lipid substrates after incubation with recombinant PI3Kδ and radioactive ATP.,,,, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,DS-7423,12616,,45378170,C[C@@H]1CN(CCN1C(=O)C)C2=NC3=C(N2CC(F)(F)F)N=C(N=C3N4CCOCC4)C5=CN=C(N=C5)N,"InChI=1S/C22H27F3N10O2/c1-13-11-33(3-4-34(13)14(2)36)21-29-16-18(32-5-7-37-8-6-32)30-17(15-9-27-20(26)28-10-15)31-19(16)35(21)12-22(23,24)25/h9-10,13H,3-8,11-12H2,1-2H3,(H2,26,27,28)/t13-/m1/s1",SOJJMSYMCLIQCZ-CYBMUJFWSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.59,,IC50,,260.0,,=,,,,24504419, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,PF-06843195,12720,,124193915,FC1=C(C2=CN=C(N)N=C2)N=C(N3CCOCC3)N=C1N[C@@]4(CO)CCN(C(OCC(F)F)=O)C4,"InChI=1S/C20H25F3N8O4/c21-13(22)9-35-19(33)31-2-1-20(10-31,11-32)29-16-14(23)15(12-7-25-17(24)26-8-12)27-18(28-16)30-3-5-34-6-4-30/h7-8,13,32H,1-6,9-11H2,(H2,24,25,26)(H,27,28,29)/t20-/m0/s1",RTOREZYNLPQUKM-FQEVSTJZSA-N,Inhibitor,Inhibition,,,,,pKi,,9.55,,Ki,,0.28,,<,,,,33356246, "phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta",2155,O00329,Human,compound (S)-29 [PMID: 37606563],12904,,,ClC1=CC=C2C(N(C3=CC=CN=C3)N=C2[C@H](C)N4C=5N=CN=C(N)C5C(C6=CC(F)=C(OC)C=C6)=N4)=C1,"InChI=1S/C26H20ClFN8O/c1-14(23-18-7-6-16(27)11-20(18)36(33-23)17-4-3-9-30-12-17)35-26-22(25(29)31-13-32-26)24(34-35)15-5-8-21(37-2)19(28)10-15/h3-14H,1-2H3,(H2,29,31,32)/t14-/m0/s1",ZNCDEDBKQOCMSJ-AWEZNQCLSA-N,Inhibitor,Inhibition,,,,,pIC50,,9.1,,IC50,,0.8,,=,,,,37606563,