target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id dual specificity tyrosine phosphorylation regulated kinase 1B,2010,Q9Y463,Human,compound 3b [PMID: 23454515],8127,,136234578,NCCOCCOCCOCCOc1ccc(cc1)NC1=N/C(=C\c2ccc3c(c2)OCO3)/C(=O)N1,"InChI=1S/C25H30N4O7/c26-7-8-31-9-10-32-11-12-33-13-14-34-20-4-2-19(3-5-20)27-25-28-21(24(30)29-25)15-18-1-6-22-23(16-18)36-17-35-22/h1-6,15-16H,7-14,17,26H2,(H2,27,28,29,30)/b21-15-",ZBYBDKHFLSHGBP-QNGOZBTKSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.14,,IC50,,72.0,,=,,,,23454515, dual specificity tyrosine phosphorylation regulated kinase 1B,2010,Q9Y463,Human,compound 17 [PMID: 23642479],8161,,46926513,Clc1cc(CNc2nccc(n2)c2ccc3c(c2)OCO3)cc(c1)Cl,"InChI=1S/C18H13Cl2N3O2/c19-13-5-11(6-14(20)8-13)9-22-18-21-4-3-15(23-18)12-1-2-16-17(7-12)25-10-24-16/h1-8H,9-10H2,(H,21,22,23)",FFJGYBJUQCZAAY-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.15,,IC50,,7.0,,=,,,,23642479, dual specificity tyrosine phosphorylation regulated kinase 1B,2010,Q9Y463,Human,compound 68 [PMID: 24900699],8165,,71529752,COC(=N)c1nc2c(s1)c1c(ncnc1cc2)Nc1ccc(cc1F)Br,"InChI=1S/C17H11BrFN5OS/c1-25-15(20)17-24-12-5-4-11-13(14(12)26-17)16(22-7-21-11)23-10-3-2-8(18)6-9(10)19/h2-7,20H,1H3,(H,21,22,23)",ZBELDPMWYXDLNY-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,9.62,,IC50,,0.24,,=,,,,24900699, dual specificity tyrosine phosphorylation regulated kinase 1B,2010,Q9Y463,Human,compound 72 [WO2013026806],8166,,71529770,COC(=N)c1nc2c(s1)c1c(ncnc1cc2)Nc1ccc(cc1)Cl,"InChI=1S/C17H12ClN5OS/c1-24-15(19)17-23-12-7-6-11-13(14(12)25-17)16(21-8-20-11)22-10-4-2-9(18)3-5-10/h2-8,19H,1H3,(H,20,21,22)",BGXZIBSLBRKDTP-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,9.55,,IC50,,0.28,,=,,,,, dual specificity tyrosine phosphorylation regulated kinase 1B,2010,Q9Y463,Human,AZ191,9268,,72716071,COc1cc(ccc1Nc1nccc(n1)c1cn(c2c1ccnc2)C)N1CCN(CC1)C,"InChI=1S/C24H27N7O/c1-29-10-12-31(13-11-29)17-4-5-21(23(14-17)32-3)28-24-26-9-7-20(27-24)19-16-30(2)22-15-25-8-6-18(19)22/h4-9,14-16H,10-13H2,1-3H3,(H,26,27,28)",ZYVXTMKTGDARKR-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.77,,IC50,,17.0,,=,,,,25738750, dual specificity tyrosine phosphorylation regulated kinase 1B,2010,Q9Y463,Human,harmine,9352,,5280953,COc1ccc2c(c1)[nH]c1c2ccnc1C,"InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3",BXNJHAXVSOCGBA-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.78,,IC50,,166.0,,=,,,,19796173, dual specificity tyrosine phosphorylation regulated kinase 1B,2010,Q9Y463,Human,voruciclib,9923,,67409219,OC[C@@H]1N(C)CC[C@H]1c1c(O)cc(c2c1oc(cc2=O)c1ccc(cc1Cl)C(F)(F)F)O,"InChI=1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21(19)20)11-3-2-10(6-13(11)23)22(24,25)26/h2-3,6-8,12,14,28-30H,4-5,9H2,1H3/t12-,14+/m1/s1",MRPGRAKIAJJGMM-OCCSQVGLSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.03,,IC50,,94.0,,=,,,,26606677,