target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id fibroblast growth factor receptor 3,1810,P22607,Human,nintedanib,5936,,135423438,COC(=O)c1ccc2c(c1)NC(=O)/C/2=C(/c1ccccc1)\Nc1ccc(cc1)N(C(=O)CN1CCN(CC1)C)C,"InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-",XZXHXSATPCNXJR-ZIADKAODSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.97,,IC50,,108.0,,=,,,,18559524, fibroblast growth factor receptor 3,1810,P22607,Human,dovitinib,5962,,135398510,CN1CCN(CC1)c1ccc2c(c1)[nH]/c(=C/1\C(=O)N=c3c(=C1N)c(F)ccc3)/[nH]2,"InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11,24-25H,7-10,23H2,1H3/b20-18-",KCOYQXZDFIIGCY-ZZEZOPTASA-N,Inhibitor,Inhibition,,,,,pIC50,8.52,,8.05,IC50,9.0,,3.0,=,,,,19113866|15598814, fibroblast growth factor receptor 3,1810,P22607,Human,fexagratinib,7707,,51039095,COc1cc(CCc2[nH]nc(c2)NC(=O)c2ccc(cc2)N2C[C@H](C)N[C@@H](C2)C)cc(c1)OC,"InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+",VRQMAABPASPXMW-HDICACEKSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.3,,IC50,,5.0,,<,,,,, fibroblast growth factor receptor 3,1810,P22607,Human,infigratinib,7877,,53235510,CCN1CCN(CC1)c1ccc(cc1)Nc1ncnc(c1)N(C(=O)Nc1c(Cl)c(OC)cc(c1Cl)OC)C,"InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)",QADPYRIHXKWUSV-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,9.0,,IC50,,1.0,,=,,,,21936542, fibroblast growth factor receptor 3,1810,P22607,Human,MK-2461,7962,,44137946,Cn1ncc(c1)c1cnc2c(c1)c(=O)c1cc(ccc1cc2)NS(=O)(=O)N(C[C@@H]1COCCO1)C,"InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1",JGEBLDKNWBUGRZ-HXUWFJFHSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.3,,IC50,,50.0,,=,,,,20145145, fibroblast growth factor receptor 3,1810,P22607,Human,LY2874455,8104,,46944259,OCCn1ncc(c1)/C=C/c1n[nH]c2c1cc(cc2)O[C@@H](c1c(Cl)cncc1Cl)C,"InChI=1S/C21H19Cl2N5O2/c1-13(21-17(22)10-24-11-18(21)23)30-15-3-5-20-16(8-15)19(26-27-20)4-2-14-9-25-28(12-14)6-7-29/h2-5,8-13,29H,6-7H2,1H3,(H,26,27)/b4-2+/t13-/m1/s1",GKJCVYLDJWTWQU-CXLRFSCWSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.19,,IC50,,6.4,,=,,,,21900693, fibroblast growth factor receptor 3,1810,P22607,Human,compound 1d [PMID: 21493067],8123,,53232451,N#Cc1cc(F)c(nc1N[C@H](c1ccc(cn1)F)C)Nc1n[nH]c(c1)C,"InChI=1S/C17H15F2N7/c1-9-5-15(26-25-9)23-17-13(19)6-11(7-20)16(24-17)22-10(2)14-4-3-12(18)8-21-14/h3-6,8,10H,1-2H3,(H3,22,23,24,25,26)/t10-/m0/s1",HIHOEGPXVVKJPP-JTQLQIEISA-N,Inhibitor,Inhibition,,,,,pIC50,,6.94,,IC50,,115.0,,=,,,,21493067, fibroblast growth factor receptor 3,1810,P22607,Human,BLU-9931,8862,,72710839,C=CC(=O)Nc1cccc(c1Nc1ncc2c(n1)ccc(c2)c1c(Cl)c(OC)cc(c1Cl)OC)C,"InChI=1S/C26H22Cl2N4O3/c1-5-21(33)30-18-8-6-7-14(2)25(18)32-26-29-13-16-11-15(9-10-17(16)31-26)22-23(27)19(34-3)12-20(35-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,33)(H,29,31,32)",TXEBNKKOLVBTFK-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.82,,IC50,,150.0,,=,,,,25776529, fibroblast growth factor receptor 3,1810,P22607,Human,erdafitinib,9039,,67462786,COc1cc(OC)cc(c1)N(c1ccc2c(c1)nc(cn2)c1cnn(c1)C)CCNC(C)C,"InChI=1S/C25H30N6O2/c1-17(2)26-8-9-31(20-10-21(32-4)13-22(11-20)33-5)19-6-7-23-24(12-19)29-25(15-27-23)18-14-28-30(3)16-18/h6-7,10-17,26H,8-9H2,1-5H3",OLAHOMJCDNXHFI-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.52,,IC50,,3.02,,=,,,,, fibroblast growth factor receptor 3,1810,P22607,Human,pemigatinib,9767,,86705695,CCN1C(=O)N(Cc2c1c1cc([nH]c1nc2)CN1CCOCC1)c1c(F)c(OC)cc(c1F)OC,"InChI=1S/C24H27F2N5O4/c1-4-30-21-14(11-27-23-16(21)9-15(28-23)13-29-5-7-35-8-6-29)12-31(24(30)32)22-19(25)17(33-2)10-18(34-3)20(22)26/h9-11H,4-8,12-13H2,1-3H3,(H,27,28)",HCDMJFOHIXMBOV-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.0,,IC50,,100.0,,<,,,,, fibroblast growth factor receptor 3,1810,P22607,Human,derazantinib,9785,,46834118,COCCNCCc1cccc(c1)Nc1ncc2c(n1)c1ccccc1[C@@H](C2)c1ccccc1F,"InChI=1S/C29H29FN4O/c1-35-16-15-31-14-13-20-7-6-8-22(17-20)33-29-32-19-21-18-26(24-10-4-5-12-27(24)30)23-9-2-3-11-25(23)28(21)34-29/h2-12,17,19,26,31H,13-16,18H2,1H3,(H,32,33,34)/t26-/m1/s1",KPJDVVCDVBFRMU-AREMUKBSSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.35,,IC50,,4.5,,=,,,,27627808, fibroblast growth factor receptor 3,1810,P22607,Human,futibatinib,9786,,71621331,C=CC(=O)N1CC[C@@H](C1)n1nc(c2c1ncnc2N)C#Cc1cc(OC)cc(c1)OC,"InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28)6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2,23,24,25)/t15-/m0/s1",KEIPNCCJPRMIAX-HNNXBMFYSA-N,Inhibitor,Inhibition,,,,,pIC50,,9.3,,IC50,,0.5,,=,,,,, fibroblast growth factor receptor 3,1810,P22607,Human,zoligratinib,9787,,66555680,Cc1nc2c([nH]1)cc(cc2)n1ncc(c1N)C(=O)c1cc2c([nH]1)cccc2,"InChI=1S/C20H16N6O/c1-11-23-16-7-6-13(9-17(16)24-11)26-20(21)14(10-22-26)19(27)18-8-12-4-2-3-5-15(12)25-18/h2-10,25H,21H2,1H3,(H,23,24)",BEMNJULZEQTDJY-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.66,,IC50,,22.0,,=,,,,25169980, fibroblast growth factor receptor 3,1810,P22607,Human,PRN1371,9788,,118295624,C=CC(=O)N1CCN(CC1)CCCn1c2nc(NC)ncc2cc(c1=O)c1c(Cl)c(OC)cc(c1Cl)OC,"InChI=1S/C26H30Cl2N6O4/c1-5-20(35)33-11-9-32(10-12-33)7-6-8-34-24-16(15-30-26(29-2)31-24)13-17(25(34)36)21-22(27)18(37-3)14-19(38-4)23(21)28/h5,13-15H,1,6-12H2,2-4H3,(H,29,30,31)",PUIXMSRTTHLNKI-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.39,,IC50,,4.1,,=,,,,28665128, fibroblast growth factor receptor 3,1810,P22607,Human,rogaratinib,9789,,71611869,COCc1c(CN2CCNC(=O)C2)n2c(c1c1cc3c(s1)c(OC)cc(c3)C)c(N)ncn2,"InChI=1S/C23H26N6O3S/c1-13-6-14-8-18(33-22(14)17(7-13)32-3)20-15(11-31-2)16(9-28-5-4-25-19(30)10-28)29-21(20)23(24)26-12-27-29/h6-8,12H,4-5,9-11H2,1-3H3,(H,25,30)(H2,24,26,27)",HNLRRJSKGXOYNO-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.61,,IC50,,24.8,,=,,,,, fibroblast growth factor receptor 3,1810,P22607,Human,TAK-632,10387,,46209401,N#Cc1c(ccc2c1sc(n2)NC(=O)C1CC1)Oc1ccc(c(c1)NC(=O)Cc1cccc(c1)C(F)(F)F)F,"InChI=1S/C27H18F4N4O3S/c28-19-7-6-17(12-21(19)33-23(36)11-14-2-1-3-16(10-14)27(29,30)31)38-22-9-8-20-24(18(22)13-32)39-26(34-20)35-25(37)15-4-5-15/h1-3,6-10,12,15H,4-5,11H2,(H,33,36)(H,34,35,37)",OJFKUJDRGJSAQB-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.55,,IC50,,280.0,,=,Biochemical enzyme inhibition assay.,,,23906342, fibroblast growth factor receptor 3,1810,P22607,Human,tasurgratinib,11414,,78323434,COCCOc1cc2c(cc1Oc1ccnc(c1)NC(=O)c1ccc(cc1)C1CCN(CC1)CCO)ccn2C(=O)NC,"InChI=1S/C32H37N5O6/c1-33-32(40)37-14-10-25-19-29(28(21-27(25)37)42-18-17-41-2)43-26-7-11-34-30(20-26)35-31(39)24-5-3-22(4-6-24)23-8-12-36(13-9-23)15-16-38/h3-7,10-11,14,19-21,23,38H,8-9,12-13,15-18H2,1-2H3,(H,33,40)(H,34,35,39)",IBHOLSBDZMIPPT-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.27,,IC50,,5.4,,=,,,,, fibroblast growth factor receptor 3,1810,P22607,Human,tinengotinib,11887,,137279257,Clc1c(cccc1)c1c2c([nH]c3c(n1)c(n[nH]3)C)cc(nc2)N1CCOCC1,"InChI=1S/C20H19ClN6O/c1-12-18-20(26-25-12)23-16-10-17(27-6-8-28-9-7-27)22-11-14(16)19(24-18)13-4-2-3-5-15(13)21/h2-5,10-11H,6-9H2,1H3,(H2,23,25,26)",DQFCVOOFMXEPOC-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.46,,IC50,,3.5,,=,,,,, fibroblast growth factor receptor 3,1810,P22607,Human,ASP5878,11934,,71736582,COc1cc(c(c(c1F)COc1cnc(nc1)Nc1cn(nc1)CCO)F)OC,"InChI=1S/C18H19F2N5O4/c1-27-14-5-15(28-2)17(20)13(16(14)19)10-29-12-7-21-18(22-8-12)24-11-6-23-25(9-11)3-4-26/h5-9,26H,3-4,10H2,1-2H3,(H,21,22,24)",VDZZYOJYLLNBTD-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.68,,IC50,,2.1,,=,,,,35219181, fibroblast growth factor receptor 3,1810,P22607,Human,compound 29 [PMID: 36356320],12313,,156273389,O=C(NC([2H])([2H])[2H])c1cc(c2c3nc(O[C@@H]4COCC4)c(c4cn(C(C)C)nc4)cn3nc2)cnc1,"InChI=1S/C23H25N7O3/c1-14(2)29-11-17(9-26-29)20-12-30-21(28-23(20)33-18-4-5-32-13-18)19(10-27-30)15-6-16(8-25-7-15)22(31)24-3/h6-12,14,18H,4-5,13H2,1-3H3,(H,24,31)/t18-/m0/s1/i3D3",XKKGIGFZDVPVNO-NGGDXUQASA-N,Inhibitor,Inhibition,,,,,pIC50,,9.3,,IC50,,0.5,,=,Inhibition of WT FGFR3 in vitro.,,,36356320, fibroblast growth factor receptor 3,1810,P22607,Human,compound 29 [PMID: 36356320],12313,,156273389,O=C(NC([2H])([2H])[2H])c1cc(c2c3nc(O[C@@H]4COCC4)c(c4cn(C(C)C)nc4)cn3nc2)cnc1,"InChI=1S/C23H25N7O3/c1-14(2)29-11-17(9-26-29)20-12-30-21(28-23(20)33-18-4-5-32-13-18)19(10-27-30)15-6-16(8-25-7-15)22(31)24-3/h6-12,14,18H,4-5,13H2,1-3H3,(H,24,31)/t18-/m0/s1/i3D3",XKKGIGFZDVPVNO-NGGDXUQASA-N,Inhibitor,Inhibition,,,,,pIC50,,8.57,,IC50,,2.7,,=,Inhibition of FGFR3V555L in vitro.,,,36356320, fibroblast growth factor receptor 3,1810,P22607,Human,"compound 7 [Nguyen et al., 2023]",12485,,146448902,CN1C(C2CCC(C1)N2C=3N=CC4=C(N3)C(=NN4)C=5C=NN(C5)C)=O,"InChI=1S/C16H18N8O/c1-22-8-10-3-4-12(15(22)25)24(10)16-17-6-11-14(19-16)13(21-20-11)9-5-18-23(2)7-9/h5-7,10,12H,3-4,8H2,1-2H3,(H,20,21)",CAWDXLYWGCKCLD-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.25,,IC50,,5.6,,=,,,,, fibroblast growth factor receptor 3,1810,P22607,Human,segigratinib,13218,,118893637,ClC1=C(C(=C(C=C1OC)OC)Cl)C2=CC=C3C(=N2)NN=C3NC(C4=CC=C(C=C4)N5CC(NCC5)(C)C)=O,"InChI=1S/C27H28Cl2N6O3/c1-27(2)14-35(12-11-30-27)16-7-5-15(6-8-16)26(36)32-25-17-9-10-18(31-24(17)33-34-25)21-22(28)19(37-3)13-20(38-4)23(21)29/h5-10,13,30H,11-12,14H2,1-4H3,(H2,31,32,33,34,36)",QNXOYMFBIACDSL-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.44,,IC50,,3.6,,=,,,,31438996,