target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id platelet derived growth factor receptor alpha,1803,P16234,Human,masitinib,5656,,10074640,CN1CCN(CC1)Cc1ccc(cc1)C(=O)Nc1ccc(c(c1)Nc1scc(n1)c1cccnc1)C,"InChI=1S/C28H30N6OS/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32)",WJEOLQLKVOPQFV-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.27,,IC50,,540.0,,=,,,,19789626, platelet derived growth factor receptor alpha,1803,P16234,Human,quizartinib,5658,,24889392,O=C(Nc1noc(c1)C(C)(C)C)Nc1ccc(cc1)c1cn2c(n1)sc1c2ccc(c1)OCCN1CCOCC1,"InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)",CVWXJKQAOSCOAB-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKd,,7.96,,Kd,,11.0,,=,,,,19754199, platelet derived growth factor receptor alpha,1803,P16234,Human,cediranib,5664,,9933475,COc1cc2c(ncnc2cc1OCCCN1CCCC1)Oc1ccc2c(c1F)cc([nH]2)C,"InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3",XXJWYDDUDKYVKI-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.44,,IC50,,36.0,,=,,,,15899831, platelet derived growth factor receptor alpha,1803,P16234,Human,nintedanib,5936,,135423438,COC(=O)c1ccc2c(c1)NC(=O)/C/2=C(/c1ccccc1)\Nc1ccc(cc1)N(C(=O)CN1CCN(CC1)C)C,"InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-",XZXHXSATPCNXJR-ZIADKAODSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.23,,IC50,,59.0,,=,,,,18559524, platelet derived growth factor receptor alpha,1803,P16234,Human,dovitinib,5962,,135398510,CN1CCN(CC1)c1ccc2c(c1)[nH]/c(=C/1\C(=O)N=c3c(=C1N)c(F)ccc3)/[nH]2,"InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11,24-25H,7-10,23H2,1H3/b20-18-",KCOYQXZDFIIGCY-ZZEZOPTASA-N,Inhibitor,Inhibition,,,,,pIC50,,6.68,,IC50,,210.0,,=,,,,15598814, platelet derived growth factor receptor alpha,1803,P26618,Mouse,PDGF receptor tyrosine kinase inhibitor II,6018,,5330548,CCCC(=O)Oc1ccc2c(c1)cc([nH]2)C(=O)c1cc2c([nH]1)cccc2,"InChI=1S/C21H18N2O3/c1-2-5-20(24)26-15-8-9-17-14(10-15)12-19(23-17)21(25)18-11-13-6-3-4-7-16(13)22-18/h3-4,6-12,22-23H,2,5H2,1H3",CZDUJGOCEPWCNA-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,5.96,,IC50,,1100.0,,=,Inhibition of PDGFR in intact Swiss 3T3 fibroblasts,,,11855980, platelet derived growth factor receptor alpha,1803,P16234,Human,lucitanib,7649,,25031915,CNC(=O)c1cccc2c1ccc(c2)Oc1ccnc2c1cc(OC)c(c2)OCC1(N)CC1,"InChI=1S/C26H25N3O4/c1-28-25(30)19-5-3-4-16-12-17(6-7-18(16)19)33-22-8-11-29-21-14-24(23(31-2)13-20(21)22)32-15-26(27)9-10-26/h3-8,11-14H,9-10,15,27H2,1-2H3,(H,28,30)",CUDVHEFYRIWYQD-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.89,,IC50,,13.0,,=,,,,22304225, platelet derived growth factor receptor alpha,1803,P16234,Human,crenolanib,7882,,10366136,NC1CCN(CC1)c1cccc2c1nc(cc2)n1cnc2c1ccc(c2)OCC1(C)COC1,"InChI=1S/C26H29N5O2/c1-26(14-32-15-26)16-33-20-6-7-22-21(13-20)28-17-31(22)24-8-5-18-3-2-4-23(25(18)29-24)30-11-9-19(27)10-12-30/h2-8,13,17,19H,9-12,14-16,27H2,1H3",DYNHJHQFHQTFTP-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pKd,,8.68,,Kd,,2.1,,=,,,,22745105, platelet derived growth factor receptor alpha,1803,P16234,Human,ENMD-2076,7885,,16041424,CN1CCN(CC1)c1nc(/C=C/c2ccccc2)nc(c1)Nc1n[nH]c(c1)C,"InChI=1S/C21H25N7/c1-16-14-20(26-25-16)23-19-15-21(28-12-10-27(2)11-13-28)24-18(22-19)9-8-17-6-4-3-5-7-17/h3-9,14-15H,10-13H2,1-2H3,(H2,22,23,24,25,26)/b9-8+",BLQYVHBZHAISJM-CMDGGOBGSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.25,,IC50,,56.0,,=,,,,19320489, platelet derived growth factor receptor alpha,1803,P16234,Human,PP121,8013,,24905142,Nc1ncnc2c1c(nn2C1CCCC1)c1cnc2c(c1)cc[nH]2,"InChI=1S/C17H17N7/c18-15-13-14(11-7-10-5-6-19-16(10)20-8-11)23-24(12-3-1-2-4-12)17(13)22-9-21-15/h5-9,12H,1-4H2,(H,19,20)(H2,18,21,22)",NVRXTLZYXZNATH-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.7,,IC50,,2.0,,=,,,,18849971, platelet derived growth factor receptor alpha,1803,P16234,Human,CP-673451,8069,,10158940,COCCOc1ccc2c(c1)ncn2c1ccc2c(n1)c(ccc2)N1CCC(CC1)N,"InChI=1S/C24H27N5O2/c1-30-13-14-31-19-6-7-21-20(15-19)26-16-29(21)23-8-5-17-3-2-4-22(24(17)27-23)28-11-9-18(25)10-12-28/h2-8,15-16,18H,9-14,25H2,1H3",DEEOXSOLTLIWMG-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.0,,IC50,,10.0,,=,,,,15705896, platelet derived growth factor receptor alpha,1803,P16234,Human,AC710,8095,,54760053,CCN1C(C)(C)CC(CC1(C)C)Oc1ccc(nc1)C(=O)Nc1ccc(cc1)NC(=O)Nc1noc(c1)C(C)(C)C,"InChI=1S/C31H42N6O4/c1-9-37-30(5,6)17-23(18-31(37,7)8)40-22-14-15-24(32-19-22)27(38)33-20-10-12-21(13-11-20)34-28(39)35-26-16-25(41-36-26)29(2,3)4/h10-16,19,23H,9,17-18H2,1-8H3,(H,33,38)(H2,34,35,36,39)",JVCWPUFNLFSKFS-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKd,,8.89,,Kd,,1.3,,=,,,,24900421, platelet derived growth factor receptor alpha,1803,P16234,Human,compound 8h [PMID: 21561767],8170,,46864270,OCCN1CCN(CC1)Cc1ccc(cc1C(F)(F)F)NC(=O)c1ccc(c(c1)C#Cc1cnc(n1C)C(=O)NC)C,"InChI=1S/C30H33F3N6O3/c1-20-4-5-22(16-21(20)7-9-25-18-35-27(37(25)3)29(42)34-2)28(41)36-24-8-6-23(26(17-24)30(31,32)33)19-39-12-10-38(11-13-39)14-15-40/h4-6,8,16-18,40H,10-15,19H2,1-3H3,(H,34,42)(H,36,41)",SUXYGJZMCWKJJI-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.89,,IC50,,1.3,,=,,,,21561767, platelet derived growth factor receptor alpha,1803,P16234,Human,compound 8h [PMID: 22765894],8175,,67161540,CCN1CCC(CC1)Nc1ccc2c(c1)C(=C(c1ncc[nH]1)c1ccc(cc1)Cl)C(=O)N2,"InChI=1S/C25H26ClN5O/c1-2-31-13-9-18(10-14-31)29-19-7-8-21-20(15-19)23(25(32)30-21)22(24-27-11-12-28-24)16-3-5-17(26)6-4-16/h3-8,11-12,15,18,29H,2,9-10,13-14H2,1H3,(H,27,28)(H,30,32)",XHCPCYVQXFHJAU-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.52,,IC50,,3.0,,=,,,,22765894, platelet derived growth factor receptor alpha,1803,P16234,Human,olaratumab,9172,,,,,,Antibody,Binding,,,yes,,pIC50,,9.24,,IC50,,0.58,,=,Cellular assay,,,, platelet derived growth factor receptor alpha,1803,P16234,Human,olaratumab,9172,,,,,,Antibody,Binding,,,yes,,pKd,,10.4,,Kd,,0.04,,=,BIAcore assay,,,, platelet derived growth factor receptor alpha,1803,P16234,Human,compound 8i [PMID: 22765894],9905,,10433653,CCN1CCC(CC1)Nc1ccc2c(c1)/C(=C(/c1ncc([nH]1)C)\c1cccc(c1)F)/C(=O)N2,"InChI=1S/C26H28FN5O/c1-3-32-11-9-19(10-12-32)30-20-7-8-22-21(14-20)24(26(33)31-22)23(25-28-15-16(2)29-25)17-5-4-6-18(27)13-17/h4-8,13-15,19,30H,3,9-12H2,1-2H3,(H,28,29)(H,31,33)/b24-23-",DMQYDVBIPXAAJA-VHXPQNKSSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.7,,IC50,,2.0,,=,,,,22765894, platelet derived growth factor receptor alpha,1803,P16234,Human,ilorasertib,9914,,46207586,OCCn1ncc(c1)c1cnc(c2c1scc2c1ccc(cc1)NC(=O)Nc1cccc(c1)F)N,"InChI=1S/C25H21FN6O2S/c26-17-2-1-3-19(10-17)31-25(34)30-18-6-4-15(5-7-18)21-14-35-23-20(12-28-24(27)22(21)23)16-11-29-32(13-16)8-9-33/h1-7,10-14,33H,8-9H2,(H2,27,28)(H2,30,31,34)",WPHKIQPVPYJNAX-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.96,,IC50,,11.0,,=,Measuring inhibition of kinase activity in a biochemical assay.,,,22935731, platelet derived growth factor receptor alpha,1803,P16234,Human,sitravatinib,9920,,25212148,COCCNCc1ccc(nc1)c1sc2c(c1)nccc2Oc1ccc(cc1F)NC(=O)C1(CC1)C(=O)Nc1ccc(cc1)F,"InChI=1S/C33H29F2N5O4S/c1-43-15-14-36-18-20-2-8-25(38-19-20)29-17-26-30(45-29)28(10-13-37-26)44-27-9-7-23(16-24(27)35)40-32(42)33(11-12-33)31(41)39-22-5-3-21(34)4-6-22/h2-10,13,16-17,19,36H,11-12,14-15,18H2,1H3,(H,39,41)(H,40,42)",WLAVZAAODLTUSW-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.52,,IC50,,30.0,,=,In a biochemical enzyme activity assay.,,,26675259, platelet derived growth factor receptor alpha,1803,P16234,Human,CHMFL-KIT-64,10420,,139030518,COc1cc2nccc(c2cc1OC)Oc1ccc(cc1)NC(=O)Cc1ccc(c(c1)C(F)(F)F)Cl,"InChI=1S/C26H20ClF3N2O4/c1-34-23-13-18-21(14-24(23)35-2)31-10-9-22(18)36-17-6-4-16(5-7-17)32-25(33)12-15-3-8-20(27)19(11-15)26(28,29)30/h3-11,13-14H,12H2,1-2H3,(H,32,33)",YOHLRCOPRAVUCJ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.6,,IC50,,25.0,,=,In a biochemical assay.,,,31250638, platelet derived growth factor receptor alpha,1803,P16234,Human,ibcasertib,10475,,49779393,COc1ccc2c(c1)nccc2Oc1ccc2c(c1)cccc2C(=O)Nc1ccccc1N,"InChI=1S/C27H21N3O3/c1-32-18-9-12-22-25(16-18)29-14-13-26(22)33-19-10-11-20-17(15-19)5-4-6-21(20)27(31)30-24-8-3-2-7-23(24)28/h2-16H,28H2,1H3,(H,30,31)",BRKWREZNORONDU-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,9.0,,IC50,,1.0,,=,Inhibition in a biochemical assay.,,,28004478, platelet derived growth factor receptor alpha,1803,P16234,Human,seralutinib,10618,,91663352,COc1cc(ccc1OC)c1cncc(n1)N[C@H](c1cccc(c1)NC(=O)c1cncc(c1)C)C,"InChI=1S/C27H27N5O3/c1-17-10-21(14-28-13-17)27(33)31-22-7-5-6-19(11-22)18(2)30-26-16-29-15-23(32-26)20-8-9-24(34-3)25(12-20)35-4/h5-16,18H,1-4H3,(H,30,32)(H,31,33)/t18-/m0/s1",JHJNPOSPVGRIAN-SFHVURJKSA-N,Inhibitor,Inhibition,,,,,,,,,,,,,=,,,,, platelet derived growth factor receptor alpha,1803,P16234,Human,vimseltinib,11190,,86267612,CC(Nc1ncc(c(=O)n1C)c1ccc(c(n1)C)Oc1ccnc(c1)c1cnn(c1)C)C,"InChI=1S/C23H25N7O2/c1-14(2)27-23-25-12-18(22(31)30(23)5)19-6-7-21(15(3)28-19)32-17-8-9-24-20(10-17)16-11-26-29(4)13-16/h6-14H,1-5H3,(H,25,27)",TVGAHWWPABTBCX-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.0,,IC50,,1000.0,,>,,,,, platelet derived growth factor receptor alpha,1803,P16234,Human,M4205,11510,,155587867,Cn1ncc(c1)c1ccc(cc1)CNc1ncnc(c1)c1cnc2n1ccc(c2)OCCCN1CCCC1,"InChI=1S/C29H32N8O/c1-35-20-24(18-34-35)23-7-5-22(6-8-23)17-30-28-16-26(32-21-33-28)27-19-31-29-15-25(9-13-37(27)29)38-14-4-12-36-10-2-3-11-36/h5-9,13,15-16,18-21H,2-4,10-12,14,17H2,1H3,(H,30,32,33)",LVMAULGVWBINFP-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.3,,IC50,,50.0,,=,Biochemical inhibitory potency,,,36728508, platelet derived growth factor receptor alpha,1803,P16234,Human,toceranib,11619,,5329106,Fc1ccc2c(c1)/C(=C/c1[nH]c(c(c1C)C(=O)NCCN1CCCC1)C)/C(=O)N2,"InChI=1S/C22H25FN4O2/c1-13-19(12-17-16-11-15(23)5-6-18(16)26-21(17)28)25-14(2)20(13)22(29)24-7-10-27-8-3-4-9-27/h5-6,11-12,25H,3-4,7-10H2,1-2H3,(H,24,29)(H,26,28)/b17-12-",SRSGVKWWVXWSJT-ATVHPVEESA-N,Inhibitor,Inhibition,,,,,pKi,,8.3,,Ki,,5.0,,=,,,,12091352, platelet derived growth factor receptor alpha,1803,P16234,Human,BPR1R024,11747,,155195529,CN(c1ccc2c(ncnc2c1)Oc1ccc(cc1)NC(=O)NCc1cnc(cc1)C(F)(F)F)C,"InChI=1S/C24H21F3N6O2/c1-33(2)17-6-9-19-20(11-17)30-14-31-22(19)35-18-7-4-16(5-8-18)32-23(34)29-13-15-3-10-21(28-12-15)24(25,26)27/h3-12,14H,13H2,1-2H3,(H2,29,32,34)",ORYMWWSJZRCUSV-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.28,,IC50,,52.7,,=,,,,34606263, platelet derived growth factor receptor alpha,1803,P16234,Human,elenestinib,12357,,155190269,C[C@](c1ccc(cc1)F)(c1cnc(nc1)N1CCN(CC1)c1ncnn2c1cc(c2)c1cn(nc1)CCO)N,"InChI=1S/C27H29FN10O/c1-27(29,21-2-4-23(28)5-3-21)22-14-30-26(31-15-22)36-8-6-35(7-9-36)25-24-12-19(17-38(24)34-18-32-25)20-13-33-37(16-20)10-11-39/h2-5,12-18,39H,6-11,29H2,1H3/t27-/m0/s1",IPMARPMXSFFZFG-MHZLTWQESA-N,Inhibitor,Inhibition,,,,,pIC50,,8.35,,IC50,,4.5,,<,"Biochemical inhibition assay, using PDGFRαD842V",,,,