target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id M5 receptor,17,P08912,Human,xanomeline,57,,60809,CCCCCCOc1nsnc1C1=CCCN(C1)C,"InChI=1S/C14H23N3OS/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12/h8H,3-7,9-11H2,1-2H3",JOLJIIDDOBNFHW-UHFFFAOYSA-N,Agonist,Partial agonist,,,,,pKi,7.4,,6.7,,,,,=,,,,9884068|10323594|16002459|36782010, M5 receptor,17,P08912,Human,amitriptyline,200,,2160,CN(CCC=C1c2ccccc2CCc2c1cccc2)C,"InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3",KRMDCWKBEZIMAB-UHFFFAOYSA-N,Antagonist,Antagonist,,,yes,,pKi,,7.8,,Ki,,15.7,,=,,,,8100134, M5 receptor,17,P08912,Human,(+)-aceclidine,286,,6954180,CC(=O)O[C@@H]1C[NH+]2CCC1CC2,"InChI=1S/C9H15NO2/c1-7(11)12-9-6-10-4-2-8(9)3-5-10/h8-9H,2-6H2,1H3/p+1/t9-/m1/s1",WRJPSSPFHGNBMG-SECBINFHSA-O,Agonist,Full agonist,,,,,pEC50,,5.5,,,,,,,,,,8968358, M5 receptor,17,P08912,Human,(-)-aceclidine,288,,6979053,CC(=O)O[C@H]1C[NH+]2CCC1CC2,"InChI=1S/C9H15NO2/c1-7(11)12-9-6-10-4-2-8(9)3-5-10/h8-9H,2-6H2,1H3/p+1/t9-/m0/s1",WRJPSSPFHGNBMG-VIFPVBQESA-O,Agonist,Partial agonist,,,,,pEC50,,5.1,,,,,,,,,,8968358, M5 receptor,17,P08912,Human,McN-A-343,290,,5926,O=C(Nc1cccc(c1)Cl)OCC#CC[N+](C)(C)C.[Cl-],"InChI=1S/C14H17ClN2O2.ClH/c1-17(2,3)9-4-5-10-19-14(18)16-13-8-6-7-12(15)11-13;/h6-8,11H,9-10H2,1-3H3;1H",CXFZFEJJLNLOTA-UHFFFAOYSA-N,Agonist,Partial agonist,,,,,pKi,,4.9,,,,,,,,,,7620715, M5 receptor,17,P08912,Human,NNC 11-1314,291,,10426487,C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccccc1,"InChI=1S/C18H19N3OS/c1-2-5-14(6-3-1)7-4-12-22-18-17(19-23-20-18)16-13-21-10-8-15(16)9-11-21/h1-3,5-6,15-16H,8-13H2",SNSMIIQEKVYNOH-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,7.8,,,,,,,,,,11504829, M5 receptor,17,P08912,Human,NNC 11-1585,292,,11757797,C1CN2CCC1C(C2)c1nsnc1OCC#Cc1ccc(cc1)C#CCOc1nsnc1C1CN2CCC1CC2,"InChI=1S/C30H32N6O2S2/c1(17-37-29-27(31-39-33-29)25-19-35-13-9-23(25)10-14-35)3-21-5-7-22(8-6-21)4-2-18-38-30-28(32-40-34-30)26-20-36-15-11-24(26)12-16-36/h5-8,23-26H,9-20H2",ROEXPZFFOZZHOY-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,8.3,,,,,,,,,,11504829, M5 receptor,17,P08912,Human,NNC 11-1607,293,,9985526,C1CN2CCC1C(C2)c1nsnc1OCC#Cc1cccc(c1)C#CCOc1nsnc1C1CN2CCC1CC2,"InChI=1S/C30H32N6O2S2/c1-4-21(6-2-16-37-29-27(31-39-33-29)25-19-35-12-8-23(25)9-13-35)18-22(5-1)7-3-17-38-30-28(32-40-34-30)26-20-36-14-10-24(26)11-15-36/h1,4-5,18,23-26H,8-17,19-20H2",TYLFZULSDOOCRC-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,8.2,,,,,,,,,,11504829, M5 receptor,17,P08912,Human,acetylcholine,294,,187,CC(=O)OCC[N+](C)(C)C,"InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1",OIPILFWXSMYKGL-UHFFFAOYSA-N,Agonist,Full agonist,,yes,,,pKi,,6.1,,,,,,=,,,,12235229, M5 receptor,17,P08912,Human,arecoline,296,,2230,COC(=O)C1=CCCN(C1)C,"InChI=1S/C8H13NO2/c1-9-5-3-4-7(6-9)8(10)11-2/h4H,3,5-6H2,1-2H3",HJJPJSXJAXAIPN-UHFFFAOYSA-N,Agonist,Agonist,,,,,,,,,,,,,=,,,,7620715|32717485, M5 receptor,17,P08912,Human,bethanechol,297,,2370,CC(C[N+](C)(C)C)OC(=O)N,"InChI=1S/C7H16N2O2/c1-6(11-7(8)10)5-9(2,3)4/h6H,5H2,1-4H3,(H-,8,10)/p+1",NZUPCNDJBJXXRF-UHFFFAOYSA-O,Agonist,Agonist,,,,,,,,,,,,,=,,,,7620715, M5 receptor,17,P08912,Human,carbachol,298,,2551,NC(=O)OCC[N+](C)(C)C,"InChI=1S/C6H14N2O2/c1-8(2,3)4-5-10-6(7)9/h4-5H2,1-3H3,(H-,7,9)/p+1",VPJXQGSRWJZDOB-UHFFFAOYSA-O,Agonist,Full agonist,,,,,pKi,,4.9,,,,,,=,,,,10323594|16002459|27461343, M5 receptor,17,P08912,Human,milameline,301,,9571002,CO/N=C/C1=CCCN(C1)C,"InChI=1S/C8H14N2O/c1-10-5-3-4-8(7-10)6-9-11-2/h4,6H,3,5,7H2,1-2H3/b9-6+",YMMXHEYLRHNXAB-RMKNXTFCSA-N,Agonist,Partial agonist,,,,,pKi,,5.4,,,,,,,,,,10323594, M5 receptor,17,P08912,Human,pilocarpine,305,,5910,CC[C@@H]1C(=O)OC[C@@H]1Cc1cncn1C,"InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1",QCHFTSOMWOSFHM-WPRPVWTQSA-N,Agonist,Partial agonist,,,,,pKi,,5.0,,,,,,=,,,,16002459|27461343|7616422, M5 receptor,17,P08912,Human,sabcomeline,306,,9577995,CO/N=C(/[C@H]1CN2CCC1CC2)\C#N,"InChI=1S/C10H15N3O/c1-14-12-10(6-11)9-7-13-4-2-8(9)3-5-13/h8-9H,2-5,7H2,1H3/b12-10+/t9-/m0/s1",IQWCBYSUUOFOMF-QTLFRQQHSA-N,Agonist,Partial agonist,,,,,pKi,,7.1,,,,,,,,,,10323594, M5 receptor,17,P08912,Human,4-DAMP,307,,1734,O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C,"InChI=1S/C21H26NO2/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-12,19-20H,13-16H2,1-2H3/q+1",HYJRTXSYDAFGJK-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,9.0,,,,,,=,,,,1994002, M5 receptor,17,P08911,Rat,4-DAMP,307,,1734,O=C(C(c1ccccc1)c1ccccc1)OC1CC[N+](CC1)(C)C,"InChI=1S/C21H26NO2/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-12,19-20H,13-16H2,1-2H3/q+1",HYJRTXSYDAFGJK-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.9,,,,,,,,,,1325587, M5 receptor,17,P08912,Human,p-F-HHSiD,308,,3603,Fc1ccc(cc1)[Si](C1CCCCC1)(CCCN1CCCCC1)O,"InChI=1S/C20H32FNOSi/c21-18-10-12-20(13-11-18)24(23,19-8-3-1-4-9-19)17-7-16-22-14-5-2-6-15-22/h10-13,19,23H,1-9,14-17H2",ZNSZQJHTFRQUPD-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.3,,,,,,,,,,8759038, M5 receptor,17,P08912,Human,otenzepad,309,,107867,CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC,"InChI=1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)",UBRKDAVQCKZSPO-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.6,,,,,,=,,,,2704370, M5 receptor,17,P08911,Rat,otenzepad,309,,107867,CCN(CC1CCCCN1CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC,"InChI=1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)",UBRKDAVQCKZSPO-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.7,,,,,,,,,,1325587, M5 receptor,17,P08912,Human,hexahydrosiladifenidol,310,,3602,O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1,"InChI=1S/C20H33NOSi/c22-23(19-11-4-1-5-12-19,20-13-6-2-7-14-20)18-10-17-21-15-8-3-9-16-21/h1,4-5,11-12,20,22H,2-3,6-10,13-18H2",QTBCATBNRIYMPB-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,7.2,,6.8,,,,,,,,,8759038|2704370, M5 receptor,17,P08911,Rat,hexahydrosiladifenidol,310,,3602,O[Si](c1ccccc1)(C1CCCCC1)CCCN1CCCCC1,"InChI=1S/C20H33NOSi/c22-23(19-11-4-1-5-12-19,20-13-6-2-7-14-20)18-10-17-21-15-8-3-9-16-21/h1,4-5,11-12,20,22H,2-3,6-10,13-18H2",QTBCATBNRIYMPB-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.4,,,,,,,,,,1325587, M5 receptor,17,P08912,Human,muscarinic toxin 3,313,,,,,,Antagonist,Antagonist,,,,,pKi,,6.0,,,,,,>,,,,7925952, M5 receptor,17,P08912,Human,muscarinic toxin 7,314,,,,,,Antagonist,Antagonist,,,,,pKi,,5.0,,,,,,>,,,,10799315, M5 receptor,17,P08912,Human,[3H]N-methyl scopolamine,317,,71183,OC[C@H](c1ccccc1)C(=O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3,"InChI=1S/C18H24NO4/c1-19(2)14-8-12(9-15(19)17-16(14)23-17)22-18(21)13(10-20)11-6-4-3-5-7-11/h3-7,12-17,20H,8-10H2,1-2H3/q+1/t12?,13-,14-,15+,16-,17+/m1/s1",LZCOQTDXKCNBEE-XJMZPCNVSA-N,Antagonist,Antagonist,,,,,pKd,9.7,,9.3,Kd,0.48,,0.2,=,,,,9846649|12235229|11303071|7562472|16369696|31772027|7687290, M5 receptor,17,P08912,Human,[3H]QNB,318,,23056,O=C(C(c1ccccc1)(c1ccccc1)O)OC1CN2CCC1CC2,"InChI=1S/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2",HGMITUYOCPPQLE-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKd,10.7,,10.22,Kd,0.06,,0.02,=,,,,7562472, M5 receptor,17,P08912,Human,atropine,320,,174174,OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C,"InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?",RKUNBYITZUJHSG-SPUOUPEWSA-N,Antagonist,Antagonist,,,yes,,pKi,9.3,,8.3,,,,,=,,,,11303071|27085897|10374898, M5 receptor,17,P08911,Rat,atropine,320,,174174,OCC(c1ccccc1)C(=O)O[C@@H]1C[C@@H]2CC[C@H](C1)N2C,"InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?",RKUNBYITZUJHSG-SPUOUPEWSA-N,Antagonist,Antagonist,,,,,pKi,,9.4,,,,,,,,,,1325587, M5 receptor,17,P08912,Human,darifenacin,321,,444031,NC(=O)C(c1ccccc1)(c1ccccc1)[C@@H]1CCN(C1)CCc1ccc2c(c1)CCO2,"InChI=1S/C28H30N2O2/c29-27(31)28(23-7-3-1-4-8-23,24-9-5-2-6-10-24)25-14-17-30(20-25)16-13-21-11-12-26-22(19-21)15-18-32-26/h1-12,19,25H,13-18,20H2,(H2,29,31)/t25-/m1/s1",HXGBXQDTNZMWGS-RUZDIDTESA-N,Antagonist,Antagonist,,,,,pKi,8.6,,7.9,,,,,=,,,,11303071|20590605|9671109, M5 receptor,17,P08912,Human,hexahydrodifenidol,322,,124226,OC(c1ccccc1)(C1CCCCC1)CCCN1CCCCC1,"InChI=1S/C21H33NO/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22/h1,4-5,11-12,20,23H,2-3,6-10,13-18H2",ILHSFCNKNNNPRN-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.1,,,,,,,,,,2704370, M5 receptor,17,P08912,Human,hexocyclium,323,,24199,C[N+]1(C)CCN(CC1)CC(c1ccccc1)(C1CCCCC1)O,"InChI=1S/C20H33N2O/c1-22(2)15-13-21(14-16-22)17-20(23,18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3,5-6,9-10,19,23H,4,7-8,11-17H2,1-2H3/q+1",ZRYHPQCHHOKSMD-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.4,,,,,,,,,,2704370, M5 receptor,17,P08912,Human,himbacine,324,,6436265,C[C@@H]1OC(=O)[C@@H]2[C@H]1[C@H](/C=C/[C@H]1CCC[C@@H](N1C)C)[C@H]1CCCC[C@@H]1C2,"InChI=1S/C22H35NO2/c1-14-7-6-9-17(23(14)3)11-12-19-18-10-5-4-8-16(18)13-20-21(19)15(2)25-22(20)24/h11-12,14-21H,4-10,13H2,1-3H3/b12-11+/t14-,15-,16+,17+,18-,19+,20-,21+/m0/s1",FMPNFDSPHNUFOS-LPJDIUFZSA-N,Antagonist,Antagonist,,,,,pKi,6.5,,5.4,,,,,=,,,,7925952|1331410|1994002, M5 receptor,17,P08912,Human,ipratropium,325,,3746,OCC(c1ccccc1)C(=O)OC1CC2CCC(C1)[N+]2(C)C(C)C,"InChI=1S/C20H30NO3/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15/h4-8,14,16-19,22H,9-13H2,1-3H3/q+1",OEXHQOGQTVQTAT-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.8,,,,,,=,,,,11303071, M5 receptor,17,P08912,Human,lithocholylcholine,326,,22991950,OC(C[N+](C)(C)C)CCCC(C1CCC2C1(C)CCC1C2CCC2C1(C)CCC(C2)O)C,"InChI=1S/C29H54NO2/c1-20(8-7-9-23(32)19-30(4,5)6)25-12-13-26-24-11-10-21-18-22(31)14-16-28(21,2)27(24)15-17-29(25,26)3/h20-27,31-32H,7-19H2,1-6H3/q+1",KWEWGNPMETZMTR-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.2,,,,,,,,,,12235229, M5 receptor,17,P08912,Human,methoctramine,327,,4108,COc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC,"InChI=1S/C36H62N4O2/c1-41-35-23-13-11-21-33(35)31-39-29-19-9-7-17-27-37-25-15-5-3-4-6-16-26-38-28-18-8-10-20-30-40-32-34-22-12-14-24-36(34)42-2/h11-14,21-24,37-40H,3-10,15-20,25-32H2,1-2H3",RPMBYDYUVKEZJA-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,7.2,,6.3,,,,,=,,,,8759038|2704370|1994002|9113359, M5 receptor,17,P08912,Human,pirenzepine,328,,4848,CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2,"InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)",RMHMFHUVIITRHF-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,7.1,,6.8,,,,,=,,,,7925952|9113359|2043926, M5 receptor,17,P08911,Rat,pirenzepine,328,,4848,CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2,"InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)",RMHMFHUVIITRHF-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.1,,,,,,,,,,1325587, M5 receptor,17,P08912,Human,scopolamine,330,,3000322,OC[C@H](c1ccccc1)C(=O)O[C@@H]1C[C@H]2N([C@@H](C1)[C@H]1[C@@H]2O1)C,"InChI=1S/C17H21NO4/c1-18-13-7-11(8-14(18)16-15(13)22-16)21-17(20)12(9-19)10-5-3-2-4-6-10/h2-6,11-16,19H,7-9H2,1H3/t11-,12-,13-,14+,15-,16+/m1/s1",STECJAGHUSJQJN-FWXGHANASA-N,Antagonist,Antagonist,,,,,pKi,,8.7,,,,,,=,,,,1346637, M5 receptor,17,P08912,Human,silahexocyclium,331,,130169,C[N+]1(C)CCN(CC1)C[Si](c1ccccc1)(C1CCCCC1)O,"InChI=1S/C19H33N2OSi/c1-21(2)15-13-20(14-16-21)17-23(22,18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3,5-6,9-10,19,22H,4,7-8,11-17H2,1-2H3/q+1",GBISIIAKUATURW-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.7,,,,,,,,,,2704370, M5 receptor,17,P08912,Human,N-benzyl brucine,332,,44358893,COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)Cc1ccccc1,"InChI=1S/C30H33N2O4/c1-34-23-13-21-22(14-24(23)35-2)31-27(33)15-25-28-20-12-26-30(21,29(28)31)9-10-32(26,17-19(20)8-11-36-25)16-18-6-4-3-5-7-18/h3-8,13-14,20,25-26,28-29H,9-12,15-17H2,1-2H3/q+1/t20-,25-,26-,28-,29-,30+,32?/m0/s1",XFMQETLKDRNYRE-QIBSSCBHSA-N,Allosteric modulator,Negative,,,,,pKd,,3.7,,,,,,,,,,9495826, M5 receptor,17,P08912,Human,N-benzyl brucine,332,,44358893,COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)Cc1ccccc1,"InChI=1S/C30H33N2O4/c1-34-23-13-21-22(14-24(23)35-2)31-27(33)15-25-28-20-12-26-30(21,29(28)31)9-10-32(26,17-19(20)8-11-36-25)16-18-6-4-3-5-7-18/h3-8,13-14,20,25-26,28-29H,9-12,15-17H2,1-2H3/q+1/t20-,25-,26-,28-,29-,30+,32?/m0/s1",XFMQETLKDRNYRE-QIBSSCBHSA-N,Allosteric modulator,Neutral,,,,,pKd,,3.7,,,,,,,,,,9495826, M5 receptor,17,P08912,Human,brucine,342,,442021,COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CCN2[C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2,"InChI=1S/C23H26N2O4/c1-27-16-8-14-15(9-17(16)28-2)25-20(26)10-18-21-13-7-19-23(14,22(21)25)4-5-24(19)11-12(13)3-6-29-18/h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H3/t13-,18-,19-,21-,22-,23+/m0/s1",RRKTZKIUPZVBMF-IBTVXLQLSA-N,Allosteric modulator,Negative,,,,,pKd,,2.9,,,,,,,,,,9495826, M5 receptor,17,P08912,Human,brucine N-oxide,343,,21123938,COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N@@+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)[O-],"InChI=1S/C23H26N2O5/c1-28-16-8-14-15(9-17(16)29-2)24-20(26)10-18-21-13-7-19-23(14,22(21)24)4-5-25(19,27)11-12(13)3-6-30-18/h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H3/t13-,18-,19-,21-,22-,23+,25+/m0/s1",HHHQMKWPZAYIAE-WAIXHZNCSA-N,Allosteric modulator,Negative,,,,,pKd,,2.3,,,,,,,,,,9495826, M5 receptor,17,P08912,Human,brucine N-oxide,343,,21123938,COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N@@+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)[O-],"InChI=1S/C23H26N2O5/c1-28-16-8-14-15(9-17(16)29-2)24-20(26)10-18-21-13-7-19-23(14,22(21)24)4-5-25(19,27)11-12(13)3-6-30-18/h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H3/t13-,18-,19-,21-,22-,23+,25+/m0/s1",HHHQMKWPZAYIAE-WAIXHZNCSA-N,Allosteric modulator,Positive,,,,,pKd,,2.3,,,,,,,,,,9495826, M5 receptor,17,P08912,Human,N-chloromethyl-brucine,344,,44358908,COc1cc2c(cc1OC)N1[C@@H]3[C@@]42CC[N+]2([C@H]4C[C@@H]4[C@H]3[C@H](CC1=O)OCC=C4C2)CCl,"InChI=1S/C24H28ClN2O4/c1-29-17-8-15-16(9-18(17)30-2)26-21(28)10-19-22-14-7-20-24(15,23(22)26)4-5-27(20,12-25)11-13(14)3-6-31-19/h3,8-9,14,19-20,22-23H,4-7,10-12H2,1-2H3/q+1/t14-,19-,20-,22-,23-,24+,27?/m0/s1",GCEPQLWZBVGLQN-CQIPDZJVSA-N,Allosteric modulator,Negative,,,,,pKd,,4.4,,,,,,,,,,9495826, M5 receptor,17,P08912,Human,strychnine,347,,441071,O=C1C[C@@H]2OCC=C3[C@H]4[C@@H]2[C@@H]2N1c1ccccc1[C@]12CCN([C@H]1C4)C3,"InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1",QMGVPVSNSZLJIA-FVWCLLPLSA-N,Allosteric modulator,Negative,,,,,pKd,,3.6,,,,,,,,,,7651370, M5 receptor,17,P08912,Human,oxybutynin,359,,4634,CCN(CC#CCOC(=O)C(c1ccccc1)(C1CCCCC1)O)CC,"InChI=1S/C22H31NO3/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3",XIQVNETUBQGFHX-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.9,,,,,,=,,,,22243489|20590605, M5 receptor,17,P08912,Human,tolterodine,360,,443879,Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O,"InChI=1S/C22H31NO/c1-16(2)23(17(3)4)14-13-20(19-9-7-6-8-10-19)21-15-18(5)11-12-22(21)24/h6-12,15-17,20,24H,13-14H2,1-5H3/t20-/m1/s1",OOGJQPCLVADCPB-HXUWFJFHSA-N,Antagonist,Antagonist,,,,,pKi,8.8,,8.5,,,,,=,,,,20590605|9671109, M5 receptor,17,P08912,Human,tripitramine,361,,132947,CN(CCCCCCNCC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CCCCCCCCN(CCCCCCN(CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)CC(=O)n1c2ncccc2[nH]c(=O)c2c1cccc2)C,"InChI=1S/C64H77N13O6/c1-72(41-20-8-5-17-35-65-44-56(78)75-53-32-14-11-26-47(53)62(81)69-50-29-23-36-66-59(50)75)39-18-6-3-4-7-19-40-73(2)42-21-9-10-22-43-74(45-57(79)76-54-33-15-12-27-48(54)63(82)70-51-30-24-37-67-60(51)76)46-58(80)77-55-34-16-13-28-49(55)64(83)71-52-31-25-38-68-61(52)77/h11-16,23-34,36-38,65H,3-10,17-22,35,39-46H2,1-2H3,(H,69,81)(H,70,82)(H,71,83)",YUJOQEAGGUIMED-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.5,,,,,,=,,,,7805774, M5 receptor,17,P08912,Human,tiotropium,367,,5487427,O=C(C(c1cccs1)(c1cccs1)O)OC1C[C@@H]2[C@@H]3[C@H]([C@H](C1)[N+]2(C)C)O3,"InChI=1S/C19H22NO4S2/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15/h3-8,11-13,16-17,22H,9-10H2,1-2H3/q+1/t11?,12-,13+,16-,17+",LERNTVKEWCAPOY-FPISHFTHSA-N,Antagonist,Antagonist,,,,,pKi,10.2,,9.8,,,,,=,,,,22854200|21036042, M5 receptor,17,P08912,Human,amiodarone,2566,,2157,CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2,"InChI=1S/C25H29I2NO3/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3",IYIKLHRQXLHMJQ-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,pKB,,7.25,,,,,,=,,,,20348203, M5 receptor,17,P08912,Human,VU0238429,3257,,42633508,COc1ccc(cc1)CN1c2ccc(cc2C(=O)C1=O)OC(F)(F)F,"InChI=1S/C17H12F3NO4/c1-24-11-4-2-10(3-5-11)9-21-14-7-6-12(25-17(18,19)20)8-13(14)15(22)16(21)23/h2-8H,9H2,1H3",CKLGZXFOLMHCMC-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,pEC50,,5.94,,EC50,,1160.0,,=,,,,19438238, M5 receptor,17,P08912,Human,AFDX384,3264,,119357,CCCN(CC1CCCCN1CCNC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CCC,"InChI=1S/C27H38N6O2/c1-3-16-31(17-4-2)20-21-10-7-8-18-32(21)19-15-29-27(35)33-24-13-6-5-11-22(24)26(34)30-23-12-9-14-28-25(23)33/h5-6,9,11-14,21H,3-4,7-8,10,15-20H2,1-2H3,(H,29,35)(H,30,34)",MZDYABXXPZNUCT-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.3,,,,,,=,,,,1994002, M5 receptor,17,P08912,Human,VU0255035,3274,,24768606,O=C(N1CCN(CC1)c1ccncc1)CCNS(=O)(=O)c1cccc2c1nsn2,"InChI=1S/C18H20N6O3S2/c25-17(24-12-10-23(11-13-24)14-4-7-19-8-5-14)6-9-20-29(26,27)16-3-1-2-15-18(16)22-28-21-15/h1-5,7-8,20H,6,9-13H2",WXDHQWPQLKGANZ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.6,,,,,,=,,,,19407080, M5 receptor,17,,Unknown,guanylpirenzepine,3276,,129786,NC(=N)N1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2,"InChI=1S/C19H21N7O2/c20-19(21)25-10-8-24(9-11-25)12-16(27)26-15-6-2-1-4-13(15)18(28)23-14-5-3-7-22-17(14)26/h1-7H,8-12H2,(H3,20,21)(H,23,28)",YGBQWISDDSXPRF-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKd,,6.8,,Kd,,175.0,,=,,,,7808421, M5 receptor,17,P08912,Human,iperoxo,6937,,10104167,C[N+](CC#CCOC1=NOCC1)(C)C,"InChI=1S/C10H17N2O2/c1-12(2,3)7-4-5-8-13-10-6-9-14-11-10/h6-9H2,1-3H3/q+1",WXXOCGISBCTWPW-UHFFFAOYSA-N,Agonist,Agonist,,,,,,,,,,,,,=,,,,24863257, M5 receptor,17,P08912,Human,biperiden,7128,,2381,OC(C1CC2CC1C=C2)(c1ccccc1)CCN1CCCCC1,"InChI=1S/C21H29NO/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2",YSXKPIUOCJLQIE-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKd,,8.2,,Kd,,6.3,,=,,,,1346637, M5 receptor,17,P08912,Human,tropicamide,7319,,5593,CCN(C(=O)C(c1ccccc1)CO)Cc1ccncc1,"InChI=1S/C17H20N2O2/c1-2-19(12-14-8-10-18-11-9-14)17(21)16(13-20)15-6-4-3-5-7-15/h3-11,16,20H,2,12-13H2,1H3",BGDKAVGWHJFAGW-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.4,,,,,,=,,,,27085897, M5 receptor,17,P08912,Human,umeclidinium,7354,,11519070,OC(C12CC[N+](CC1)(CC2)CCOCc1ccccc1)(c1ccccc1)c1ccccc1,"InChI=1S/C29H34NO2/c31-29(26-12-6-2-7-13-26,27-14-8-3-9-15-27)28-16-19-30(20-17-28,21-18-28)22-23-32-24-25-10-4-1-5-11-25/h1-15,31H,16-24H2/q+1",FVTWTVQXNAJTQP-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,9.9,,,,,,=,,,,23435542, M5 receptor,17,P08912,Human,methacholine,7438,,1993,CC(C[N+](C)(C)C)OC(=O)C,"InChI=1S/C8H18NO2/c1-7(11-8(2)10)6-9(3,4)5/h7H,6H2,1-5H3/q+1",NZWOPGCLSHLLPA-UHFFFAOYSA-N,Agonist,Agonist,,,,,,,,,,,,,=,,,,7620715, M5 receptor,17,P08912,Human,aclidinium,7449,,11434515,O=C(C(c1cccs1)(c1cccs1)O)O[C@H]1C[N+]2(CCCOc3ccccc3)CCC1CC2,"InChI=1S/C26H30NO4S2/c28-25(26(29,23-9-4-17-32-23)24-10-5-18-33-24)31-22-19-27(14-11-20(22)12-15-27)13-6-16-30-21-7-2-1-3-8-21/h1-5,7-10,17-18,20,22,29H,6,11-16,19H2/q+1/t20?,22-,27?/m0/s1",ASMXXROZKSBQIH-VITNCHFBSA-N,Antagonist,Antagonist,,,,,pKi,,9.9,,,,,,=,,,,21036042, M5 receptor,17,P08912,Human,glycopyrrolate,7459,,3494,O=C(C(c1ccccc1)(C1CCCC1)O)OC1CC[N+](C1)(C)C,"InChI=1S/C19H28NO3/c1-20(2)13-12-17(14-20)23-18(21)19(22,16-10-6-7-11-16)15-8-4-3-5-9-15/h3-5,8-9,16-17,22H,6-7,10-14H2,1-2H3/q+1",ANGKOCUUWGHLCE-UHFFFAOYSA-N,Antagonist,Antagonist,,,yes,,pKi,9.9,,8.9,,,,,=,,,,21036043|22854200, M5 receptor,17,P08912,Human,solifenacin,7483,,154059,O=C(N1CCc2c([C@@H]1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2,"InChI=1S/C23H26N2O2/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19/h1-9,18,21-22H,10-16H2/t21-,22-/m0/s1",FBOUYBDGKBSUES-VXKWHMMOSA-N,Antagonist,Antagonist,,,,,pKi,,7.2,,,,,,=,,,,20590605, M5 receptor,17,P08912,Human,dosulepin,7549,,5282426,CN(CC/C=C/1\c2ccccc2SCc2c1cccc2)C,"InChI=1S/C19H21NS/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3/b17-11-",PHTUQLWOUWZIMZ-BOPFTXTBSA-N,Antagonist,Antagonist,,,,,pKi,,7.04,,Ki,,92.0,,=,,,,8100134, M5 receptor,17,P08912,Human,ML375,7631,,71598521,Clc1ccc(cc1)[C@]12N(CCN1C(=O)c1c2cccc1)C(=O)c1ccc(c(c1)F)F,"InChI=1S/C23H15ClF2N2O2/c24-16-8-6-15(7-9-16)23-18-4-2-1-3-17(18)22(30)28(23)12-11-27(23)21(29)14-5-10-19(25)20(26)13-14/h1-10,13H,11-12H2/t23-/m0/s1",GXBAKXRLQAPKEE-QHCPKHFHSA-N,Allosteric modulator,Negative,,,,,pKB,6.6,,6.2,,,,,=,,,,24164599|27461343|34351123, M5 receptor,17,P08912,Human,VU0119498,7632,,3008304,Brc1ccc(cc1)CN1c2ccccc2C(=O)C1=O,"InChI=1S/C15H10BrNO2/c16-11-7-5-10(6-8-11)9-17-13-4-2-1-3-12(13)14(18)15(17)19/h1-8H,9H2",DELLOEULSHGYCG-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,pEC50,,5.4,,EC50,,4080.0,,=,,,,19438238, M5 receptor,17,P08912,Human,UH-AH 37,8583,,129140,CN1CCC(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1c(Cl)ccc2,"InChI=1S/C21H22ClN3O2/c1-24-11-9-14(10-12-24)13-19(26)25-18-8-3-2-5-15(18)21(27)23-17-7-4-6-16(22)20(17)25/h2-8,14H,9-13H2,1H3,(H,23,27)",UFJWXHOFKIGIAF-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.3,,,,,,=,,,,2043926|9671109, M5 receptor,17,P08912,Human,AQ-RA 741,8584,,129989,CCN(CCCCC1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2c1nccc2)CC,"InChI=1S/C27H37N5O2/c1-3-30(4-2)17-8-7-10-21-14-18-31(19-15-21)20-25(33)32-24-13-6-5-11-22(24)27(34)29-23-12-9-16-28-26(23)32/h5-6,9,11-13,16,21H,3-4,7-8,10,14-15,17-20H2,1-2H3,(H,29,34)",BCUGCHZRMKTPMU-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,7.8,,6.1,,,,,=,,,,1994002|9671109, M5 receptor,17,P08912,Human,AE9C90CB,8586,,9862598,CN(C(=O)C(c1ccccc1)(c1ccccc1)O)C[C@@H]1[C@H]2[C@@H]1CNC2,"InChI=1S/C21H24N2O2/c1-23(14-19-17-12-22-13-18(17)19)20(24)21(25,15-8-4-2-5-9-15)16-10-6-3-7-11-16/h2-11,17-19,22,25H,12-14H2,1H3/t17-,18+,19-",AARSINSGAQDAKQ-REPLKXPHSA-N,Antagonist,Antagonist,,,,,pKi,,9.5,,,,,,=,,,,20590605, M5 receptor,17,P08912,Human,ML381,8591,,42519285,CN(C(=O)c1noc(c1)COc1cccc(c1)C(=O)C)[C@H](c1ccccn1)C,"InChI=1S/C21H21N3O4/c1-14(19-9-4-5-10-22-19)24(3)21(26)20-12-18(28-23-20)13-27-17-8-6-7-16(11-17)15(2)25/h4-12,14H,13H2,1-3H3/t14-/m0/s1",JMYDHMCYZKRDPD-AWEZNQCLSA-N,Antagonist,Antagonist,,,,,pKi,,6.3,,,,,,=,,,,24692176, M5 receptor,17,P08912,Human,[3H]acetylcholine,8593,,187,CC(=O)OCC[N+](C)(C)C,"InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1",OIPILFWXSMYKGL-UHFFFAOYSA-N,Agonist,Agonist,,,,,,,,,,,,,=,,,,, M5 receptor,17,P08912,Human,ML380,8687,,71737672,CCN(C(=O)C1CCN(CC1)S(=O)(=O)c1ccc2c(c1)cn[nH]2)Cc1ccccc1C(F)(F)F,"InChI=1S/C23H25F3N4O3S/c1-2-29(15-17-5-3-4-6-20(17)23(24,25)26)22(31)16-9-11-30(12-10-16)34(32,33)19-7-8-21-18(13-19)14-27-28-21/h3-8,13-14,16H,2,9-12,15H2,1H3,(H,27,28)",FJPQEOQGIZSLES-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,pKB,,4.8,,,,,,=,,,,25147929|27461343, M5 receptor,17,P08912,Human,(S)-dimetindene,10104,,6604866,CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C,"InChI=1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3/t15-/m1/s1",MVMQESMQSYOVGV-OAHLLOKOSA-N,Antagonist,Antagonist,,,,,pKi,,6.12,,Ki,,758.6,,=,Binding to hM5 receptors expressed in CHO cells.,,,12593665, M5 receptor,17,P08912,Human,revefenacin,10129,,11753673,O=C(Nc1ccccc1c1ccccc1)OC1CCN(CC1)CCN(C(=O)c1ccc(cc1)CN1CCC(CC1)C(=O)N)C,"InChI=1S/C35H43N5O4/c1-38(34(42)29-13-11-26(12-14-29)25-40-19-15-28(16-20-40)33(36)41)23-24-39-21-17-30(18-22-39)44-35(43)37-32-10-6-5-9-31(32)27-7-3-2-4-8-27/h2-14,28,30H,15-25H2,1H3,(H2,36,41)(H,37,43)",FYDWDCIFZSGNBU-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.2,,Ki,,6.31,,=,"Determined from a radioligand binding assay using membranes from CHO‐K1 cells expressing the hM5 receptor, and displacement of [3H]NMS tracer.",,,29736245, M5 receptor,17,P08912,Human,[3H]iperoxo,12486,,167993643,[3H][N+](C)(C)CC#CCOC1=NOCC1,"InChI=1S/C9H14N2O2/c1-11(2)6-3-4-7-12-9-5-8-13-10-9/h5-8H2,1-2H3/p+1/i/hT",CADHNBBPGYVTOA-MNYXATJNSA-O,Agonist,Agonist,,,,,pKd,,8.3,,Kd,,5.0,,=,,,,24863257,