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Na-Cl symporter

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Target id: 970

Nomenclature: Na-Cl symporter

Abbreviated Name: NCC

Systematic Nomenclature: SLC12A3

Family: SLC12 family of cation-coupled chloride transporters

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 12 1021 16q13 SLC12A3 solute carrier family 12 member 3 1
Mouse 12 1002 8 46.46 cM Slc12a3 solute carrier family 12, member 3
Rat 12 1002 19p13-p12 Slc12a3 solute carrier family 12 member 3
Previous and Unofficial Names Click here for help
Thiazide-sensitive sodium-chloride cotransporter | TSC | NCCT | solute carrier family 12 (sodium/chloride transporters), member 3 | solute carrier family 12 (sodium/chloride transporter), member 3 | solute carrier family 12
Database Links Click here for help
Specialist databases
Bioparadigms SLC Tables SLC12A3 (Hs)
RESOLUTE SLC12A3 (Hs)
Other databases
Alphafold P55017 (Hs), P59158 (Mm), P55018 (Rn)
ChEMBL Target CHEMBL1876 (Hs)
DrugBank Target P55017 (Hs)
Ensembl Gene ENSG00000070915 (Hs), ENSMUSG00000031766 (Mm), ENSRNOG00000057072 (Rn)
Entrez Gene 6559 (Hs), 20497 (Mm), 54300 (Rn)
Human Protein Atlas ENSG00000070915 (Hs)
KEGG Gene hsa:6559 (Hs), mmu:20497 (Mm), rno:54300 (Rn)
OMIM 600968 (Hs)
Orphanet ORPHA118740 (Hs)
Pharos P55017 (Hs)
UniProtKB P55017 (Hs), P59158 (Mm), P55018 (Rn)
Wikipedia SLC12A3 (Hs)
Stoichiometry Click here for help
1 Na+ : 1 Cl- (in)

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
cyclothiazide Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Inhibition - -
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chlorothiazide Small molecule or natural product Approved drug Primary target of this compound Hs Inhibition - -
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hydrochlorothiazide Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition - -
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metolazone Small molecule or natural product Approved drug Primary target of this compound Hs Inhibition - -
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Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Gitelman syndrome
Disease Ontology: DOID:0050450
OMIM: 263800
Orphanet: ORPHA358
References:  2

References

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1. Mastroianni N, De Fusco M, Zollo M, Arrigo G, Zuffardi O, Bettinelli A, Ballabio A, Casari G. (1996) Molecular cloning, expression pattern, and chromosomal localization of the human Na-Cl thiazide-sensitive cotransporter (SLC12A3). Genomics, 35 (3): 486-93. [PMID:8812482]

2. Sabath E, Meade P, Berkman J, de los Heros P, Moreno E, Bobadilla NA, Vázquez N, Ellison DH, Gamba G. (2004) Pathophysiology of functional mutations of the thiazide-sensitive Na-Cl cotransporter in Gitelman disease. Am J Physiol Renal Physiol, 287 (2): F195-203. [PMID:15068971]

How to cite this page

SLC12 family of cation-coupled chloride transporters: Na-Cl symporter. Last modified on 01/04/2015. Accessed on 28/10/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=970.