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Kidney-specific Na-K-Cl symporter

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Target id: 968

Nomenclature: Kidney-specific Na-K-Cl symporter

Abbreviated Name: NKCC2

Systematic Nomenclature: SLC12A1

Family: SLC12 family of cation-coupled chloride transporters

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 12 1099 15q21.1 SLC12A1 solute carrier family 12 member 1
Mouse 12 1095 2 61.23 cM Slc12a1 solute carrier family 12, member 1
Rat 12 1095 3q36 Slc12a1 solute carrier family 12 member 1
Previous and Unofficial Names Click here for help
BSC2 | Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 | NKCC2 | Solute carrier family 12 member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter) | urehr3 | solute carrier family 12 (sodium/potassium/chloride transporters), member 1 | solute carrier family 12 (sodium/potassium/chloride transporter), member 1 | solute carrier family 12
Database Links Click here for help
Specialist databases
Bioparadigms SLC Tables SLC12A1 (Hs)
RESOLUTE SLC12A1 (Hs)
Other databases
Alphafold Q13621 (Hs), P55014 (Mm), P55016 (Rn)
ChEMBL Target CHEMBL1874 (Hs)
DrugBank Target Q13621 (Hs)
Ensembl Gene ENSG00000074803 (Hs), ENSMUSG00000027202 (Mm), ENSRNOG00000005367 (Rn)
Entrez Gene 6557 (Hs), 20495 (Mm), 25065 (Rn)
Human Protein Atlas ENSG00000074803 (Hs)
KEGG Gene hsa:6557 (Hs), mmu:20495 (Mm), rno:25065 (Rn)
OMIM 600839 (Hs)
Orphanet ORPHA118737 (Hs)
Pharos Q13621 (Hs)
UniProtKB Q13621 (Hs), P55014 (Mm), P55016 (Rn)
Wikipedia SLC12A1 (Hs)
Stoichiometry Click here for help
1 Na+ : 1 K+ : 2 Cl- (in)

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
bumetanide Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 6.5 pIC50 2
⤷ pIC50 6.5 [2]
piretanide Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.0 pIC50 2
⤷ pIC50 6.0 [2]
furosemide Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 5.2 pIC50 2
⤷ pIC50 5.2 [2]
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Bartter syndrome, antenatal, type 1
Synonyms: Antenatal Bartter syndrome [Orphanet: ORPHA93604]
Bartter disease [Disease Ontology: DOID:445]
Disease Ontology: DOID:445
OMIM: 601678
Orphanet: ORPHA93604
References:  1

References

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1. Adachi M, Asakura Y, Sato Y, Tajima T, Nakajima T, Yamamoto T, Fujieda K. (2007) Novel SLC12A1 (NKCC2) mutations in two families with Bartter syndrome type 1. Endocr J, 54 (6): 1003-7. [PMID:17998760]

2. Hannaert P, Alvarez-Guerra M, Pirot D, Nazaret C, Garay RP. (2002) Rat NKCC2/NKCC1 cotransporter selectivity for loop diuretic drugs. Naunyn Schmiedebergs Arch Pharmacol, 365 (3): 193-9. [PMID:11882915]

How to cite this page

SLC12 family of cation-coupled chloride transporters: Kidney-specific Na-K-Cl symporter. Last modified on 18/07/2014. Accessed on 20/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=968.