Gene and Protein Information
class C G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	852	1p36.33	TAS1R3	taste 1 receptor member 3
Mouse	7	858	4 87.65 cM	Tas1r3	taste receptor, type 1, member 3
Rat	7	858	5q36	Tas1r3	taste 1 receptor member 3

Previous and Unofficial Names

sweet taste receptor T1R3 | taste receptor

Database Links
Specialist databases
GPCRdb	ts1r3_human (Hs), ts1r3_mouse (Mm), ts1r3_rat (Rn)
Other databases
Alphafold	Q7RTX0 (Hs), Q925D8 (Mm), Q923K1 (Rn)
ChEMBL Target	CHEMBL1613742 (Hs)
Ensembl Gene	ENSG00000169962 (Hs), ENSMUSG00000029072 (Mm), ENSRNOG00000019589 (Rn)
Entrez Gene	83756 (Hs), 83771 (Mm), 170634 (Rn)
Human Protein Atlas	ENSG00000169962 (Hs)
KEGG Gene	hsa:83756 (Hs), mmu:83771 (Mm), rno:170634 (Rn)
OMIM	605865 (Hs)
Pharos	Q7RTX0 (Hs)
RefSeq Nucleotide	NM_152228 (Hs), NM_031872 (Mm), NM_130818 (Rn)
RefSeq Protein	NP_689414 (Hs), NP_114078 (Mm), NP_570831 (Rn)
UniProtKB	Q7RTX0 (Hs), Q925D8 (Mm), Q923K1 (Rn)
Wikipedia	TAS1R3 (Hs)

Download all structure-activity data for this target as a CSV file

Allosteric Modulators
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference lactisole Hs Negative 4.2 pIC50 1 ⤷ pIC50 4.2 (IC50 6.5x10-5 M) [1] Description: Measuring inhibition of aspartame-induced sweet receptor activation

General Comments
TAS1R3 is a putative sweet taste receptor