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Target id: 604
Nomenclature: Farnesoid X receptor-β
Systematic Nomenclature: NR1H5
Gene and Protein Information | |||||
Species | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 1p13.2 | NR1H5P | nuclear receptor subfamily 1 group H member 5, pseudogene | |
Mouse | 505 | 3 F2.2 | Nr1h5 | nuclear receptor subfamily 1, group H, member 5 | 1 |
Rat | - | 2q34 | Nr1h5 | nuclear receptor subfamily 1, group H, member 5 | |
Gene and Protein Information Comments | |||||
FXRb is a pseudogene in human[1] |
Previous and Unofficial Names |
FXRβ | Lanosterol receptor | Nr1h5p | nuclear receptor subfamily 1, group H, member 5, pseudogene | nuclear receptor subfamily 1 |
Database Links | |
Ensembl Gene | ENSG00000227970 (Hs), ENSMUSG00000048938 (Mm), ENSRNOG00000023073 (Rn) |
Entrez Gene | 643609 (Hs), 381463 (Mm), 690430 (Rn) |
Human Protein Atlas | ENSG00000227970 (Hs) |
KEGG Gene | hsa:643609 (Hs), mmu:381463 (Mm), rno:690430 (Rn) |
OMIM | 3026618 (Hs) |
RefSeq Nucleotide | NM_201619 (Mm), NM_198658 (Mm), NM_201622 (Mm) |
RefSeq Protein | NP_963916 (Mm), NP_963913 (Mm), NP_941060 (Mm) |
Wikipedia | NR1H5P (Hs) |
Natural/Endogenous Ligands |
cholesten |
desmosterol |
lanosterol |
vitamin D3 |
Comments: A series of oxysterols and bile acids are natural ligands |
Download all structure-activity data for this target as a CSV file
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Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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DNA Binding | |||||||
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DNA Binding Comments | |||||||
Also binds as RXR heterodimer to an everted repeat with a spacer of 2 (ER2). |
Main Co-regulators | ||||||
Name | Activity | Specific | Ligand dependent | AF-2 dependent | Comments | References |
NCOA1 | Co-activator | No | Yes | No | 1 |
Tissue Distribution | ||||||||
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Biologically Significant Variants | ||||||||||||
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1. Otte K, Kranz H, Kober I, Thompson P, Hoefer M, Haubold B, Remmel B, Voss H, Kaiser C, Albers M, Cheruvallath Z, Jackson D, Casari G, Koegl M, Pääbo S, Mous J, Kremoser C, Deuschle U. (2003) Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol. Mol Cell Biol, 23 (3): 864-72. [PMID:12529392]