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Kv1.7

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Target id: 544

Nomenclature: Kv1.7

Family: Voltage-gated potassium channels (Kv)

Contents:

Gene and Protein Information Click here for help
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 6 1 456 19q13.33 KCNA7 potassium voltage-gated channel subfamily A member 7 5
Mouse 6 1 489 7 29.3 cM Kcna7 potassium voltage-gated channel, shaker-related subfamily, member 7 5
Rat 6 1 457 1q22 Kcna7 potassium voltage-gated channel subfamily A member 7 5
Previous and Unofficial Names Click here for help
HAK6 | KCNA7 | potassium voltage-gated channel subfamily A member 7 | potassium channel, voltage gated shaker related subfamily A, member 7 | potassium voltage-gated channel
Database Links Click here for help
Alphafold Q96RP8 (Hs), Q17ST2 (Mm)
ChEMBL Target CHEMBL2773 (Hs)
DrugBank Target Q96RP8 (Hs)
Ensembl Gene ENSG00000104848 (Hs), ENSMUSG00000038201 (Mm), ENSRNOG00000020779 (Rn)
Entrez Gene 3743 (Hs), 16495 (Mm), 365241 (Rn)
Human Protein Atlas ENSG00000104848 (Hs)
KEGG Gene hsa:3743 (Hs), mmu:16495 (Mm), rno:365241 (Rn)
OMIM 176268 (Hs)
Pharos Q96RP8 (Hs)
RefSeq Nucleotide NM_031886 (Hs), NM_010596 (Mm), NM_001108914 (Rn)
RefSeq Protein NP_114092 (Hs), NP_034726 (Mm), NP_001102384 (Rn)
UniProtKB Q96RP8 (Hs), Q17ST2 (Mm)
Wikipedia KCNA7 (Hs)
Functional Characteristics Click here for help
KV
Ion Selectivity and Conductance Click here for help
Species:  Mouse
Rank order:  K+ [21.0 pS]
References:  5
Species:  Mouse
Macroscopic current rectification:  Ik: Delayed Rectifier K+ current
References:  5
Voltage Dependence Click here for help
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -8.0 - 5 RBL Cells Mouse
Inactivation  - 14.0 5
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -8.0 5.8 1 COS-7 Mouse
Inactivation  - -
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -4.3 - 4 Xenopus laevis oocyte Mouse
Inactivation  -21.0 181.8 4
Comments  mKV1.7L isoform.
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  4.4 - 4 Xenopus laevis oocyte Mouse
Inactivation  -40.0 643.2 4
Comments  mKV1.7S isoform.
Associated subunits (Human)
Kv β1 and Kv β2

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Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Concentration range (M) Holding voltage (mV) Reference
flecainide Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs - 5.1 pKd - - 1
⤷ pKd 5.1 [1]
quinidine Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Guide to Malaria Pharmacology Ligand Hs - 4.8 pKd - - 1
⤷ pKd 4.8 [1]
verapamil Small molecule or natural product Approved drug Click here for species-specific activity table Hs - 4.8 pKd - - 1
⤷ pKd 4.8 [1]
amiodarone Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Hs - 4.5 pKd - - 1
⤷ pKd 4.5 [1]
tetraethylammonium Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs - 4.1 pKd - - 1
⤷ pKd 4.1 [1]
fampridine Small molecule or natural product Approved drug Click here for species-specific activity table Mm Pore blocker 3.8 pKd - - 4
⤷ pKd 3.8 [4]
ShK Toxin Peptide Mm - 7.9 pIC50 - - 5
⤷ pIC50 7.9 [5]
noxiustoxin Peptide Click here for species-specific activity table Mm - 7.7 pIC50 - - 5
⤷ pIC50 7.7 [5]
margatoxin Peptide Mm - 6.9 pIC50 - - 5
⤷ pIC50 6.9 [5]
conkunitzin-S1 toxin Peptide Mm Pore blocker 6.4 pIC50 - - 3
⤷ pIC50 6.4 (IC50 4.39x10-7 M) [3]
CP-339818 Small molecule or natural product Click here for species-specific activity table Mm - 5.0 pIC50 - - 5
⤷ pIC50 5.0 [5]
nifedipine Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Mm - 4.9 pIC50 - - 5
⤷ pIC50 4.9 [5]
resiniferatoxin Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Mm - 4.7 pIC50 - - 5
⤷ pIC50 4.7 [5]
tedisamil Small molecule or natural product Mm - 4.7 pIC50 - - 5
⤷ pIC50 4.7 [5]
capsaicin Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Mm - 4.6 pIC50 - - 5
⤷ pIC50 4.6 [5]
diltiazem Small molecule or natural product Approved drug Click here for species-specific activity table Ligand has a PDB structure Mm - 4.2 pIC50 - - 5
⤷ pIC50 4.2 [5]
fampridine Small molecule or natural product Approved drug Click here for species-specific activity table Mm - 3.6 pIC50 - - 5
⤷ pIC50 3.6 (IC50 2.45x10-4 M) [5]
cromakalim Small molecule or natural product Click here for species-specific activity table Mm - 3.3 pIC50 - - 5
⤷ pIC50 3.3 [5]
tetraethylammonium Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Mm - 1.1 pIC50 - - 5
⤷ pIC50 1.1 [5]
View species-specific channel blocker tables
Tissue Distribution Click here for help
Heart, skeletal muscle > liver, lung > placenta, brain, islets > spleen, kidney, testes.
Species:  Mouse
Technique:  RT-PCR
References:  5
Heart, lung > brain.
Species:  Rat
Technique:  RT-PCR
References:  2
Pancreatic β-cells
Species:  Rat
Technique: 
References:  3
Functional Assays Click here for help
Voltage clamp of cloned mouse channel expressed in RBL cells reveals A-type K+ current.
Species:  Mouse
Tissue:  RBL Cells.
Response measured:  A-type potassium current.
References:  5
Voltage clamp of cloned human channel expressed in COS-7 cells reveals similarity to IKur current.
Species:  Human
Tissue:  COS-7 Cells.
Response measured:  IKur like current.
References:  1
Physiological Functions Click here for help
KV1.7 plays an important role in the repolarization of cell membranes.
Species:  Human
Tissue:  Cell membrane.
References:  6
KV1.7 has properties similar to the ultra-rapidly activating IKur current in the heart.
Species:  Human
Tissue:  Heart.
References:  1
KV1.7 regulates glucose-stimulated insulin secretion
Species:  Rat
Tissue:  Pancreatic beta cells
References:  3
Biologically Significant Variant Comments
A total of 198 SNPs have been identified in human KCNG4. For more information please see the entry on GeneCards.
General Comments
Can co-assemble with other KV1 family members in heteromultimers, but not with members of other KV families. Unlike the other known Kv1 family members, the gene for Kv1.7 has a 1.9Kb intron in the coding region [1,5-6].

References

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1. Bardien-Kruger S, Wulff H, Arieff Z, Brink P, Chandy KG, Corfield V. (2002) Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI). Eur J Hum Genet, 10 (1): 36-43. [PMID:11896454]

2. Davies AR, Kozlowski RZ. (2001) Kv channel subunit expression in rat pulmonary arteries. Lung, 179 (3): 147-61. [PMID:11891605]

3. Finol-Urdaneta RK, Remedi MS, Raasch W, Becker S, Clark RB, Strüver N, Pavlov E, Nichols CG, French RJ, Terlau H. (2012) Block of Kv1.7 potassium currents increases glucose-stimulated insulin secretion. EMBO Mol Med, 4 (5): 424-34. [PMID:22438204]

4. Finol-Urdaneta RK, Strüver N, Terlau H. (2006) Molecular and Functional Differences between Heart mKv1.7 Channel Isoforms. J Gen Physiol, 128 (1): 133-45. [PMID:16801386]

5. Kalman K, Nguyen A, Tseng-Crank J, Dukes ID, Chandy G, Hustad CM, Copeland NG, Jenkins NA, Mohrenweiser H, Brandriff B et al.. (1998) Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7. J Biol Chem, 273 (10): 5851-7. [PMID:9488722]

6. Kashuba VI, Kvasha SM, Protopopov AI, Gizatullin RZ, Rynditch AV, Wahlestedt C, Wasserman WW, Zabarovsky ER. (2001) Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family. Gene, 268 (1-2): 115-22. [PMID:11368907]

Contributors

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