Gene and Protein Information
Species	TM	P Loops	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	6	1	624	5q31.2	PKD2L2	polycystin 2 like 2, transient receptor potential cation channel	3
Mouse	6	1	621	18 B1	Pkd2l2	polycystic kidney disease 2-like 2	1
Rat	6	1	621	18p12	Pkd2l2	polycystin 2 like 2, transient receptor potential cation channel

Previous and Unofficial Names

TRPP5 | polycystin 2 like 2 | polycystin 2 like 2, transient receptor potential cation channel

Database Links
Alphafold	Q9NZM6 (Hs), Q9JLG4 (Mm)
Ensembl Gene	ENSG00000078795 (Hs), ENSMUSG00000014503 (Mm), ENSRNOG00000025489 (Rn)
Entrez Gene	27039 (Hs), 53871 (Mm), 291683 (Rn)
Human Protein Atlas	ENSG00000078795 (Hs)
KEGG Gene	hsa:27039 (Hs), mmu:53871 (Mm), rno:291683 (Rn)
OMIM	604669 (Hs)
Pharos	Q9NZM6 (Hs)
RefSeq Nucleotide	NM_014386 (Hs), NM_016927 (Mm), NM_001106156 (Rn)
RefSeq Protein	NP_055201 (Hs), NP_058623 (Mm), NP_001099626 (Rn)
UniProtKB	Q9NZM6 (Hs), Q9JLG4 (Mm)
Wikipedia	PKD2L2 (Hs)

Functional Characteristics
TRPP3 is not fully characterized yet. One report suggests the single channel activity of PKD2L2 in HEK293 cells as a 25 pS conductance [2], but these recordings have not been confirmed.

Tissue Distribution
Testis Species:  Human Technique:  Northern Blot References:  3
Widely expressed in fetal tissues (tissue-specific expression of splice variants). Species:  Human Technique:  RT-PCR References:  1
Testis, heart Species:  Mouse Technique:  Northern Blot References:  1

Functional Assays
Patch clamp (inside-out configuration) Species:  Human Tissue:  HEK 293 overexpressing TRPP3 Response measured:  Single channel current. This has not, however, been definitively identified as due to TRPP3. References:  2

Phenotypes, Alleles and Disease Models	Mouse data from MGI
Show »« Hide Allele Composition & genetic background Accession Phenotype Id Phenotype Reference Pkd2l2tm1Dgen Pkd2l2tm1Dgen/Pkd2l2tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:1858231  MP:0001399 hyperactivity

General Comments
No known association with human polycystic kidney disease.