Contents:
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 2 | 441 | 22q11.21 | P2RX6 | purinergic receptor P2X 6 | 11 |
| Mouse | 2 | 389 | 16 A3 | P2rx6 | purinergic receptor P2X, ligand-gated ion channel, 6 | 8 |
| Rat | 2 | 389 | 11q23 | P2rx6 | purinergic receptor P2X 6 | 3 |
| Gene and Protein Information Comments | ||||||
| Seventy-four P2X6 genes have been identified in the genomes of 71 placental mammalian species (Eutheria). (Multi-copies in two species) [12]. | ||||||
| Previous and Unofficial Names |
| P2RXL1 | P2XM | P2X purinoceptor 6 | P2X6 receptor | purinergic receptor P2X-like 1 orphan receptor | Rnap2x6 | RNRNAP2X6 | purinergic receptor P2X, ligand-gated ion channel, 6 | purinergic receptor P2X, ligand gated ion channel, 6 | purinergic receptor P2X |
| Database Links |
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| Alphafold | O15547 (Hs), O54803 (Mm), P51579 (Rn) |
| CATH/Gene3D | 2.60.490.10 |
| ChEMBL Target | CHEMBL2670 (Hs), CHEMBL2122 (Rn) |
| Ensembl Gene | ENSG00000099957 (Hs), ENSMUSG00000022758 (Mm), ENSRNOG00000001873 (Rn) |
| Entrez Gene | 9127 (Hs), 18440 (Mm), 25041 (Rn) |
| Human Protein Atlas | ENSG00000099957 (Hs) |
| KEGG Gene | hsa:9127 (Hs), mmu:18440 (Mm), rno:25041 (Rn) |
| OMIM | 608077 (Hs) |
| Pharos | O15547 (Hs) |
| RefSeq Nucleotide | NM_005446 (Hs), NM_011028 (Mm), NM_012721 (Rn) |
| RefSeq Protein | NP_005437 (Hs), NP_035158 (Mm), NP_036853 (Rn) |
| UniProtKB | O15547 (Hs), O54803 (Mm), P51579 (Rn) |
| Wikipedia | P2RX6 (Hs) |
| Natural/Endogenous Ligands |
| ATP |
Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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| Immunopharmacology Comments |
| P2X ligand-gated ion channels elicit pro-inflammatory immune responses upon activation by extracellular ATP that acts as a DAMP when released from damaged or infected cells [1-2]. |
| Cell Type Associations | ||||||||
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| Physiological Consequences of Altering Gene Expression
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| General Comments |
| P2X6 is largely retained in the endoplasmic reticulum and fails to exit as a homopolymer, although it may do as a heteropolymer (with P2X2 or P2X4, and with both). However, enhanced glycosylation of P2X6 may improve trafficking of P2X6 homopolymers and can result in functional ATP-activated receptors [6-7,10]. |
References
1. Burnstock G, Boeynaems JM. (2014) Purinergic signalling and immune cells. Purinergic Signal, 10 (4): 529-64. [PMID:25352330]
2. Cekic C, Linden J. (2016) Purinergic regulation of the immune system. Nat Rev Immunol, 16 (3): 177-92. [PMID:26922909]
3. Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G. (1996) Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J Neurosci, 16 (8): 2495-507. [PMID:8786426]
4. de Baaij JH, Kompatscher A, Viering DH, Bos C, Bindels RJ, Hoenderop JG. (2016) P2X6 Knockout Mice Exhibit Normal Electrolyte Homeostasis. PLoS ONE, 11 (6): e0156803. [PMID:27254077]
5. Jacobson KA, Jarvis MF, Williams M. (2002) Purine and pyrimidine (P2) receptors as drug targets. J Med Chem, 45 (19): 4057-93. [PMID:12213051]
6. Jones CA, Vial C, Sellers LA, Humphrey PP, Evans RJ, Chessell IP. (2004) Functional regulation of P2X6 receptors by N-linked glycosylation: identification of a novel alpha beta-methylene ATP-sensitive phenotype. Mol Pharmacol, 65 (4): 979-85. [PMID:15044628]
7. Kaczmarek-Hájek K, Lörinczi E, Hausmann R, Nicke A. (2012) Molecular and functional properties of P2X receptors--recent progress and persisting challenges. Purinergic Signal, 8 (3): 375-417. [PMID:22547202]
8. Nawa G, Urano T, Tokino T, Ochi T, Miyoshi Y. (1998) Cloning and characterization of the murine P2XM receptor gene. J Hum Genet, 43 (4): 262-7. [PMID:9852680]
9. Przybyła T, Sakowicz-Burkiewicz M, Pawełczyk T. (2018) Purinergic signaling in B cells. Acta Biochim Pol, 65 (1): 1-7. [PMID:29360885]
10. Robinson LE, Murrell-Lagnado RD. (2013) The trafficking and targeting of P2X receptors. Front Cell Neurosci, 7: 233. [PMID:24319412]
11. Urano T, Nishimori H, Han H, Furuhata T, Kimura Y, Nakamura Y, Tokino T. (1997) Cloning of P2XM, a novel human P2X receptor gene regulated by p53. Cancer Res, 57 (15): 3281-7. [PMID:9242461]
12. Zdobnov EM, Tegenfeldt F, Kuznetsov D, Waterhouse RM, Simão FA, Ioannidis P, Seppey M, Loetscher A, Kriventseva EV. (2017) OrthoDB v9.1: cataloging evolutionary and functional annotations for animal, fungal, plant, archaeal, bacterial and viral orthologs. Nucleic Acids Res, 45 (D1): D744-D749. [PMID:27899580]
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