Top ▲

GluK4

Click here for help

Target id: 453

Nomenclature: GluK4

Family: Ionotropic glutamate receptors

Contents:

Gene and Protein Information Click here for help
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 3 1 956 11q23.3 GRIK4 glutamate ionotropic receptor kainate type subunit 4
Mouse 3 1 956 9 23.8 cM Grik4 glutamate receptor, ionotropic, kainate 4
Rat 3 1 956 8q22 Grik4 glutamate ionotropic receptor kainate type subunit 4
Previous and Unofficial Names Click here for help
GRIK | glutamate receptor KA-1 | GluRgamma1 | EAA1 | GLUK1 | KA1 | glutamate receptor
Database Links Click here for help
Alphafold Q16099 (Hs), Q8BMF5 (Mm), Q01812 (Rn)
ChEMBL Target CHEMBL2109241 (Hs), CHEMBL3044 (Rn)
Ensembl Gene ENSG00000149403 (Hs), ENSMUSG00000032017 (Mm), ENSRNOG00000030910 (Rn)
Entrez Gene 2900 (Hs), 110637 (Mm), 24406 (Rn)
Human Protein Atlas ENSG00000149403 (Hs)
KEGG Gene hsa:2900 (Hs), mmu:110637 (Mm), rno:24406 (Rn)
OMIM 600282 (Hs)
Pharos Q16099 (Hs)
RefSeq Nucleotide NM_014619 (Hs), NM_175481 (Mm), NM_012572 (Rn)
RefSeq Protein NP_055434 (Hs), NP_780690 (Mm), NP_036704 (Rn)
UniProtKB Q16099 (Hs), Q8BMF5 (Mm), Q01812 (Rn)
Wikipedia GRIK4 (Hs)
Natural/Endogenous Ligands Click here for help
L-glutamic acid

Download all structure-activity data for this target as a CSV file go icon to follow link

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand
Sp.
Action
[3H]SYM2081 Small molecule or natural product Click here for species-specific activity table Ligand is labelled Ligand is radioactive Hs Full agonist - -
⤷
[3H]kainate Small molecule or natural product Click here for species-specific activity table Ligand is labelled Ligand is radioactive Hs Full agonist - -
⤷
domoic acid Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Full agonist - -
⤷
dysiherbaine Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Full agonist - -
⤷
kainate Small molecule or natural product Click here for species-specific activity table Hs Full agonist - -
⤷
SYM2081 Small molecule or natural product Click here for species-specific activity table Hs Full agonist - -
⤷

Contributors

Show »

How to cite this page

Bettler B, Collingridge GL, Dingledine R, Heinemann SF, Hollmann M, Lerma J, Lodge D, Mayer M, Mishina M, Mulle C, Nakanishi S, Olsen R, Peineau S, Peters JA, Seeburg P, Spedding M, Watkins JC. Ionotropic glutamate receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE. 2023; 2023(1). Available from: https://doi.org/10.2218/gtopdb/F75/2023.1.