Contents:
- Gene and Protein Information
- Previous and Unofficial Names
- Database Links
- Natural/Endogenous Ligands
- Agonists
- Antagonists
- Transduction Mechanisms
- Tissue Distribution
- Expression Datasets
- Functional Assays
- Physiological Functions
- Phenotypes, Alleles and Disease Models
- References
- Contributors
- How to cite this page
Gene and Protein Information  |
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| class A G protein-coupled receptor | ||||||
| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 7 | 388 | 20p11.21 | SSTR4 | somatostatin receptor 4 | 10,35,52 |
| Mouse | 7 | 385 | 2 73.44 cM | Sstr4 | somatostatin receptor 4 | 40 |
| Rat | 7 | 384 | 3q41 | Sstr4 | somatostatin receptor 4 | 3 |
| Previous and Unofficial Names |
| SRIF2B |
| Database Links |
|
| Specialist databases | |
| GPCRdb | ssr4_human (Hs), ssr4_mouse (Mm), ssr4_rat (Rn) |
| Other databases | |
| Alphafold | P31391 (Hs), P49660 (Mm), P30937 (Rn) |
| ChEMBL Target | CHEMBL1853 (Hs), CHEMBL4397 (Mm) |
| Ensembl Gene | ENSG00000132671 (Hs), ENSMUSG00000037014 (Mm), ENSRNOG00000004641 (Rn) |
| Entrez Gene | 6754 (Hs), 20608 (Mm), 25555 (Rn) |
| Human Protein Atlas | ENSG00000132671 (Hs) |
| KEGG Gene | hsa:6754 (Hs), mmu:20608 (Mm), rno:25555 (Rn) |
| OMIM | 182454 (Hs) |
| Pharos | P31391 (Hs) |
| RefSeq Nucleotide | NM_001052 (Hs), NM_009219 (Mm), NM_013036 (Rn) |
| RefSeq Protein | NP_001043 (Hs), NP_033245 (Mm), NP_037168 (Rn) |
| UniProtKB | P31391 (Hs), P49660 (Mm), P30937 (Rn) |
| Wikipedia | SSTR4 (Hs) |
| Natural/Endogenous Ligands |
| cortistatin-14 {Sp: Mouse, Rat} |
| CST-17 {Sp: Human} |
| SRIF-14 {Sp: Human, Mouse, Rat} |
| SRIF-28 {Sp: Human, Mouse, Rat} |
| Comments: SRIF-14 and SRIF-28 are the active fragments of precursor somatostatin. SST4 has lower affinity for SRIF-14 and SRIF-28 than the other somatostatin receptor subtypes. |
Download all structure-activity data for this target as a CSV file 
| Agonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| View species-specific agonist tables | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Antagonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Antagonist Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| No selective antagonists available. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Primary Transduction Mechanisms
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| Transducer | Effector/Response |
| Gi/Go family | Adenylyl cyclase inhibition |
| References: 2,10,29,43 | |
| Secondary Transduction Mechanisms |
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| Transducer | Effector/Response |
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Gi/Go family G protein (identity unknown) |
Potassium channel Calcium channel Other - See Comments |
| Comments: Activation of K+ channels and inhibition of Ca2+ channels is via Gi/Go G-proteins. Protein tyrosine phosphatase (PTP), Na+/H+ exchanger (NHE1), MAPK cascade and PLA2 activation are via unknown G-proteins. | |
| References: 2,14-15,17,20-21,23,32,38,41,46-47,53 | |
| Tissue Distribution
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| Expression Datasets |
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| Phenotypes, Alleles and Disease Models
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References
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