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DNA topoisomerase 4

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Target id: 3227

Nomenclature: DNA topoisomerase 4

Family: Bacterial protein targets

Contents:

Quaternary Structure: Subunits
DNA topoisomerase 4 subunit A
DNA topoisomerase 4 subunit B
Quaternary Structure Comments
DNA topoisomerase 4 is a tetrameric enzyme, consisting of DNA topoisomerase 4 A (parC) and B (parE) subunits assembled into an A2B2 complex.
Previous and Unofficial Names Click here for help
Topoisomerase IV | Topo IV
Database Links Click here for help
ChEMBL Target CHEMBL2363076 (E.coli)

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Inhibitors
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Ligand Sp. Action Value Parameter Reference
BWC0977 Small molecule or natural product Click here for species-specific activity table E.coli Inhibition 8.0 pIC50
⤷ pIC50 8.0 (IC50 1x10-8 M)
General Comments
DNA topoisomerase 4 (also know as Topoisomerase IV) is a Type II DNA topoisomerase [1-2]. It is one of two enzymes of this subclass found in bacteria, the other being DNA gyrase. DNA topoisomerase 4 decatenates interlinked daughter chromosomes following DNA replication [3]. It catalyzes ATP-dependent breakage, passage and rejoining of double-stranded DNA.

References

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1. Kato J, Nishimura Y, Imamura R, Niki H, Hiraga S, Suzuki H. (1990) New topoisomerase essential for chromosome segregation in E. coli. Cell, 63 (2): 393-404. [PMID:2170028]

2. Kato J, Suzuki H, Ikeda H. (1992) Purification and characterization of DNA topoisomerase IV in Escherichia coli. J Biol Chem, 267 (36): 25676-84. [PMID:1334483]

3. Zechiedrich EL, Khodursky AB, Cozzarelli NR. (1997) Topoisomerase IV, not gyrase, decatenates products of site-specific recombination in Escherichia coli. Genes Dev, 11 (19): 2580-92. [PMID:9334322]

How to cite this page

Bacterial protein targets: DNA topoisomerase 4. Last modified on 22/05/2025. Accessed on 29/10/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3227.