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CTP synthase 2

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Target id: 3216

Nomenclature: CTP synthase 2

Family: Nucleotide turnover

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 586 Xp22.2 CTPS2 CTP synthase 2
Mouse - 586 X F4 Ctps2 cytidine 5'-triphosphate synthase 2
Rat - 586 Xq14 Ctps2 CTP synthase 2
Previous and Unofficial Names Click here for help
cytidine 5'-triphosphate synthase 2 | CTP synthase II
Database Links Click here for help
Alphafold Q9NRF8 (Hs), P70303 (Mm), Q5U2N0 (Rn)
BRENDA 6.3.4.2
Ensembl Gene ENSG00000047230 (Hs), ENSMUSG00000031360 (Mm), ENSRNOG00000004257 (Rn)
Entrez Gene 56474 (Hs), 55936 (Mm), 619580 (Rn)
Human Protein Atlas ENSG00000047230 (Hs)
KEGG Enzyme 6.3.4.2
KEGG Gene hsa:56474 (Hs), mmu:55936 (Mm), rno:619580 (Rn)
Pharos Q9NRF8 (Hs)
UniProtKB Q9NRF8 (Hs), P70303 (Mm), Q5U2N0 (Rn)
Wikipedia CTPS2 (Hs)
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Human CTPS2 bound to inhibitor T35
PDB Id:  7MII
Ligand:  compound 27 [PMID: 36449304]
Resolution:  2.7Å
Species:  Human
References:  1
Enzyme Reaction Click here for help
EC Number: 6.3.4.2

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 27 [PMID: 36449304] Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.7 pIC50 2
⤷ pIC50 7.7 (IC50 1.8x10-8 M) [2]
compound 27 [PMID: 36449304] Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Rn Inhibition 7.6 pIC50 2
⤷ pIC50 7.6 (IC50 2.3x10-8 M) [2]
compound 27 [PMID: 36449304] Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Mm Inhibition 7.5 pIC50 2
⤷ pIC50 7.5 (IC50 3.3x10-8 M) [2]
View species-specific inhibitor tables

References

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1. Lynch EM, DiMattia MA, Albanese S, van Zundert GCP, Hansen JM, Quispe JD, Kennedy MA, Verras A, Borrelli K, Toms AV et al.. (2021) Structural basis for isoform-specific inhibition of human CTPS1. Proc Natl Acad Sci U S A, 118 (40): e2107968118. [PMID:34583994]

2. Novak A, Laughton D, Lane R, Blackham E, Thomas J, Chatzopoulou E, Wrigglesworth J, Quddus A, Ahmed S, Cousin D et al.. (2022) Discovery and Optimization of Potent and Orally Available CTP Synthetase Inhibitors for Use in Treatment of Diseases Driven by Aberrant Immune Cell Proliferation. J Med Chem, 65 (24): 16640-16650. [PMID:36449304]

How to cite this page

Nucleotide turnover: CTP synthase 2. Last modified on 06/01/2023. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3216.