Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	314	Xq28	MAGEA3	MAGE family member A3

Previous and Unofficial Names

antigen MZ2-D | cancer/testis antigen family 1, member 3 | MAGE-3 antigen | melanoma-associated antigen 3

Database Links
Alphafold	P43357 (Hs)
ChEMBL Target	CHEMBL4662941 (Hs)
Ensembl Gene	ENSG00000221867 (Hs)
Entrez Gene	4102 (Hs)
Human Protein Atlas	ENSG00000221867 (Hs)
KEGG Gene	hsa:4102 (Hs)
OMIM	300174 (Hs)
Pharos	P43357 (Hs)
RefSeq Nucleotide	NM_005362 (Hs)
RefSeq Protein	NP_005353 (Hs)
UniProtKB	P43357 (Hs)
Wikipedia	MAGEA3 (Hs)

Physiological Consequences of Altering Gene Expression
Overexpression of MAGEA3 in the liver is associated with more aggressive tumours in vivo. Species:  Mouse Tissue:  Whole animal Technique:  References:  1
Silencing MAGEA3 in human hepatocellular carcinoma (HCC) cell lines decreases cell proliferation, colony formation and increases apoptosis. Species:  Human Tissue:  HCC cell lines Technique:  Gene silencing References:  1

General Comments

MAGEA3 is one member of the extensive family of genes that encode cancer testis antigens (CTAs). Expression of CTAs is restricted to germ cells in normal tissues, but can be aberrantly reactivated in cancer tissues. The melanoma antigen (MAGE) family [2-3], is a CTA subset of ~40 genes (HGNC gene family 1136) whose expression is oncogenic. Transcriptomic analysis of tumour samples from patients with hepatocellular carcinoma (HCC) identified MAGEA3 as a significant enhancer of HCC progression [1].