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Plasmodium falciparum subtilisin-like protease 1

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Target id: 3184

Nomenclature: Plasmodium falciparum subtilisin-like protease 1

Abbreviated Name: PfSUB1

Family: Peptidases and proteinases (Plasmodium spp.)

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 688 SUB1 subtilisin-like protease 1
Previous and Unofficial Names Click here for help
PFE0370c
Database Links Click here for help
Alphafold
PlasmoDB
UniProtKB
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 3j [PMID: 33975947] Small molecule or natural product Guide to Malaria Pharmacology Ligand Pf3D7 - 8.2 pIC50 1
pIC50 8.2 (IC50 5.7x10-9 M) [1]
Whole Organism Assay Data Linked to This Target
Key to terms and symbols Click column headers to sort
Ligand Sp. Assay description Type Action Value Parameter Reference
compound 3j [PMID: 33975947] Small molecule or natural product Guide to Malaria Pharmacology Ligand Pf3D7 Parasite growth inhibition assay - - 6.6 pEC50 1
pEC50 6.6 (EC50 2.6x10-7 M) SYBR Green I assay [1]
Lifecycle stages: Plasmodium asexual blood stage (erythrocytic merozoite, trophozoite, erythrocytic schizont)
Malaria Pharmacology Comments
P. falciparum subtilisin-like protease 1 (PfSUB1) is a serine protease involved in the process of merozoite release from host erythrocytes (egress) and is essential for survival of the parasite.

References

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1. Lidumniece E, Withers-Martinez C, Hackett F, Collins CR, Perrin AJ, Koussis K, Bisson C, Blackman MJ, Jirgensons A. (2021) Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1. Proc Natl Acad Sci U S A, 118 (20). [PMID:33975947]

How to cite this page

Peptidases and proteinases (Plasmodium spp.): Plasmodium falciparum subtilisin-like protease 1. Last modified on 12/10/2021. Accessed on 30/06/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3184.