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hydroxysteroid 11-beta dehydrogenase 2

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Target id: 3143

Nomenclature: hydroxysteroid 11-beta dehydrogenase 2

Abbreviated Name: 11-βHSD2

Family: 1.-.-.- Oxidoreductases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 405 16q22.1 HSD11B2 hydroxysteroid 11-beta dehydrogenase 2
Mouse - 386 8 53.04 cM Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2
Database Links Click here for help
Alphafold P80365 (Hs), P51661 (Mm)
ChEMBL Target CHEMBL3746 (Hs), CHEMBL3490 (Mm)
Ensembl Gene ENSG00000176387 (Hs), ENSMUSG00000031891 (Mm)
Entrez Gene 3291 (Hs), 15484 (Mm)
Human Protein Atlas ENSG00000176387 (Hs)
KEGG Gene hsa:3291 (Hs), mmu:15484 (Mm)
OMIM 614232 (Hs)
Pharos P80365 (Hs)
UniProtKB P80365 (Hs), P51661 (Mm)
Wikipedia HSD11B2 (Hs)

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
enoxolone Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.9 pIC50 2
⤷ pIC50 8.9 (IC50 1.2x10-9 M) [2]
enoxolone Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Rn Inhibition 6.4 pIC50 1
⤷ pIC50 6.4 (IC50 3.6x10-7 M) [1]
View species-specific inhibitor tables

References

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1. Beseda I, Czollner L, Shah PS, Khunt R, Gaware R, Kosma P, Stanetty C, Del Ruiz-Ruiz MC, Amer H, Mereiter K et al.. (2010) Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases. Bioorg Med Chem, 18 (1): 433-54. [PMID:19914836]

2. Chen XQ, Shao LD, Pal M, Shen Y, Cheng X, Xu G, Peng LY, Wang K, Pan ZH, Li MM et al.. (2015) Hupehenols A-E, selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors from Viburnum hupehense. J Nat Prod, 78 (2): 330-4. [PMID:25590374]

How to cite this page

1.-.-.- Oxidoreductases: hydroxysteroid 11-beta dehydrogenase 2. Last modified on 01/10/2020. Accessed on 20/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3143.