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Plasmodium falciparum cyclic amine resistance locus protein

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Target id: 3074

Nomenclature: Plasmodium falciparum cyclic amine resistance locus protein

Abbreviated Name: PfCARL

Family: Transporters (Plasmodium spp.)

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Plasmodium falciparum 3D7 - 1283 CARL cyclic amine resistance locus protein
Previous and Unofficial Names Click here for help
CARL | Pf3D7_03_v3:921,776..928,618(+) | PFC0970w
Database Links Click here for help
Alphafold C0H483 (Pf3D7)
PlasmoDB PF3D7_0321900 (Pf3D7)
UniProtKB C0H483 (Pf3D7)
Malaria Pharmacology Comments
The P. falciparum cyclic amine resistance locus (PfCARL) encodes a seven-transmembrane domain protein that localizes to the cis-Golgi apparatus of the parasite in both asexual and sexual blood stages [1]. Homology analysis provides an insight into possible function: the S. cerevisiae homolog, Emp65, is a part of a molecular chaperone complex in the endoplasmic reticulum and the mouse homolog, Tapt1, is involved in embryonic skeletal formation, signal transduction, and hormone trafficking [1,3].
Mutations in PfCARL are associated with parasite resistance to two distinct compound classes: the imidazolopiperazines, a novel class of antimalarial compounds that includes the clinical candidate ganaplacide, and the benzimidazolyl piperidines, with the suggestion that PfCARL is a multidrug-resistance gene rather than the common target [1-2].

References

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1. LaMonte G, Lim MY, Wree M, Reimer C, Nachon M, Corey V, Gedeck P, Plouffe D, Du A, Figueroa N et al.. (2016) Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug Resistance. MBio, 7 (4). [PMID:27381290]

2. Magistrado PA, Corey VC, Lukens AK, LaMonte G, Sasaki E, Meister S, Wree M, Winzeler E, Wirth DF. (2016) Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes. ACS Infect Dis, 2 (11): 816-826. [PMID:27933786]

3. Zhang S, Xu C, Larrimore KE, Ng DTW. (2017) Slp1-Emp65: A Guardian Factor that Protects Folding Polypeptides from Promiscuous Degradation. Cell, 171 (2): 346-357.e12. [PMID:28919078]

How to cite this page

Transporters (Plasmodium spp.): Plasmodium falciparum cyclic amine resistance locus protein. Last modified on 13/12/2021. Accessed on 17/05/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3074.