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Target id: 3065
Nomenclature: Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase
Abbreviated Name: PfPPPK-DHPS
Family: Antimalarial targets
Gene and Protein Information ![]() |
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Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Plasmodium falciparum 3D7 | - | 706 | PPPK-DHPS | hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase |
Database Links ![]() |
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PlasmoDB | PF3D7_0810800 (Pf3D7) |
UniProtKB | Q8IAU3 (Pf3D7) |
Download all structure-activity data for this target as a CSV file
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Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||
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Whole Organism Assay Data Linked to This Target | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Malaria Pharmacology Comments |
The Plasmodium enzyme hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase (PfPPPK-DHPS) is a bifunctional protein involved in the folate biosynthesis pathway and in the mechanism of action of the sulfonamide group of drugs [1]. |
1. Triglia T, Cowman AF. (1994) Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum. Proc. Natl. Acad. Sci. U.S.A., 91 (15): 7149-53. [PMID:8041761]
2. Wang P, Read M, Sims PF, Hyde JE. (1997) Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization. Mol. Microbiol., 23 (5): 979-86. [PMID:9076734]
3. Zhang Y, Meshnick SR. (1991) Inhibition of Plasmodium falciparum dihydropteroate synthetase and growth in vitro by sulfa drugs. Antimicrob. Agents Chemother., 35 (2): 267-71. [PMID:2024960]
Antimalarial targets: Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase. Last modified on 05/08/2020. Accessed on 20/01/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=3065.