Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	4	244	11q12.1	MS4A2	membrane spanning 4-domains A2
Mouse	4	235	19 8.46 cM	Ms4a2	membrane-spanning 4-domains, subfamily A, member 2
Rat	4	243	1q43	Ms4a2	membrane spanning 4-domains A2
Gene and Protein Information Comments
The human MS4A2 gene produces two protein isoforms: isoform 1 (244aa) that traffics to the cytoplasmic membrane and isoform 3 (199aa) that triffics preferentially to the nuclear membrane. Four mouse protein isoforms are predicted.

Previous and Unofficial Names

membrane-spanning 4-domains, subfamily A, member 2 | membrane-spanning 4-domains | APY | FCεR1β | FCεRIβ | IGEL | IGER

Database Links
Alphafold	Q01362 (Hs), P20490 (Mm), P13386 (Rn)
Ensembl Gene	ENSG00000149534 (Hs), ENSMUSG00000024680 (Mm), ENSRNOG00000020993 (Rn)
Entrez Gene	2206 (Hs), 14126 (Mm), 25316 (Rn)
Human Protein Atlas	ENSG00000149534 (Hs)
KEGG Gene	hsa:2206 (Hs), mmu:14126 (Mm), rno:25316 (Rn)
OMIM	147138 (Hs)
Pharos	Q01362 (Hs)
RefSeq Nucleotide	NM_000139 (Hs), NM_001256916 (Hs), NM_013516 (Mm), NM_012845 (Rn)
RefSeq Protein	NP_000130 (Hs), NP_001243845 (Hs), NP_038544 (Mm), NP_036977 (Rn)
UniProtKB	Q01362 (Hs), P20490 (Mm), P13386 (Rn)
Wikipedia	MS4A2 (Hs)

Immunopharmacology Comments

The protein product of the MS4A2 gene is the β subunit of the FCεRI. It has commonly known as FCER1B. The IgE-receptor (FCεRI), is a tetramer composed of an α, β, and 2 disulfide-linked γ chains expressed on the surface of mast cells and basophils that is crucial for mediating the allergic response. It has been suggested that cytoplasmic FCER1B that is not associated with FCεRI complexes may act as a negative regulator of the signalling pathway to degranulation by sequestering important signalling partners such as the Lyn tyrosine kinase [1].

Immuno Process Associations

Immuno Process:  Immune regulation

Immuno Process:  Cellular signalling

Immuno Process:  Inflammation

Immuno Process:  Cytokine production & signalling