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Fc fragment of IgE receptor Ia

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Target id: 2933

Nomenclature: Fc fragment of IgE receptor Ia

Abbreviated Name: FCεR1α

Family: Fc epsilon receptors

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 257 1q23.2 FCER1A Fc epsilon receptor Ia
Mouse 1 250 1 80.33 cM Fcer1a Fc receptor, IgE, high affinity I, alpha polypeptide
Rat 1 245 13q24 Fcer1a Fc epsilon receptor Ia
Previous and Unofficial Names Click here for help
Fc receptor, IgE, high affinity I, alpha polypeptide | Fc receptor
Database Links Click here for help
Alphafold P12319 (Hs), P20489 (Mm), P12371 (Rn)
CATH/Gene3D 2.60.40.10
ChEMBL Target CHEMBL2248 (Hs)
Ensembl Gene ENSG00000179639 (Hs), ENSMUSG00000005339 (Mm), ENSRNOG00000009177 (Rn)
Entrez Gene 2205 (Hs), 14125 (Mm), 25047 (Rn)
Human Protein Atlas ENSG00000179639 (Hs)
KEGG Gene hsa:2205 (Hs), mmu:14125 (Mm), rno:25047 (Rn)
OMIM 47140 (Hs)
Pharos P12319 (Hs)
RefSeq Nucleotide NM_002001 (Hs), NM_010184 (Mm), NM_012724 (Rn)
RefSeq Protein NP_001992 (Hs), NP_034314 (Mm), NP_036856 (Rn)
UniProtKB P12319 (Hs), P20489 (Mm), P12371 (Rn)
Wikipedia FCER1A (Hs)

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Agonists
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Value Parameter Reference
IgE heavy chain Peptide Primary target of this compound Click here for species-specific activity table Immunopharmacology Ligand Hs Binding 10.0 pKd
⤷ pKd 10.0 (Kd 1x10-10 M)
Immunopharmacology Comments
The product of the FCεR1A gene is a single-pass type I membrane protein that is a high-affinity receptor for immunoglobulin E (IgE). It is the ligand binding subunit of the tetrameric FCεRI, exhibiting a Kd of ~0.1nM.
Cell Type Associations
Immuno Cell Type:  Granulocytes
Cell Ontology Term:   basophil (CL:0000767)
eosinophil (CL:0000771)
Immuno Cell Type:  Macrophages & monocytes
Comment:  Langerhans cells
Immuno Cell Type:  Mast cells

How to cite this page

Fc epsilon receptors: Fc fragment of IgE receptor Ia. Last modified on 08/05/2017. Accessed on 31/10/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2933.