Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	404	19p13.2	CD209	CD209 molecule
Gene and Protein Information Comments
A number of splice variants, encoding different protein isoforms of human CD209 have been identified. The mouse has five CD209 homologs and there are no rat homologs.

Previous and Unofficial Names

CDSIGN | CLEC4L

Database Links
Alphafold	Q9NNX6 (Hs)
CATH/Gene3D	3.10.100.10
ChEMBL Target	CHEMBL1795114 (Hs)
Ensembl Gene	ENSG00000090659 (Hs)
Entrez Gene	30835 (Hs)
Human Protein Atlas	ENSG00000090659 (Hs)
KEGG Gene	hsa:30835 (Hs)
OMIM	604672 (Hs)
Pharos	Q9NNX6 (Hs)
RefSeq Nucleotide	NM_021155 (Hs)
RefSeq Protein	NP_066978 (Hs)
UniProtKB	Q9NNX6 (Hs)
Wikipedia	CD209 (Hs)

Immunopharmacology Comments

DC-SIGN is a pathogen-recognition receptor involved in initiating the primary immune response to various viral and bacterial pathogens, as well as antigen presentation and initiation of the adaptive immune response.

Cell Type Associations

Immuno Cell Type:  Macrophages & monocytes

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 1 GO processes click arrow to show/hide IEA associations GO:0045087 innate immune response IEA

Immuno Process:  Antigen presentation GO Annotations:  Associated to 3 GO processes GO:0019882 antigen processing and presentation NAS GO:0046968 peptide antigen transport NAS click arrow to show/hide IEA associations GO:0006897 endocytosis IEA

Immuno Process:  T cell (activation) GO Annotations:  Associated to 3 GO processes GO:0042102 positive regulation of T cell proliferation IDA GO:0042129 regulation of T cell proliferation IDA click arrow to show/hide IEA associations GO:0002250 adaptive immune response IEA

Immuno Process:  Immune regulation GO Annotations:  Associated to 2 GO processes GO:0042102 positive regulation of T cell proliferation IDA GO:0042129 regulation of T cell proliferation IDA

Immuno Process:  Chemotaxis & migration GO Annotations:  Associated to 3 GO processes GO:0007159 leukocyte cell-cell adhesion NAS GO:0042102 positive regulation of T cell proliferation IDA GO:0097323 B cell adhesion IDA

Immuno Process:  Cellular signalling GO Annotations:  Associated to 2 GO processes GO:0042102 positive regulation of T cell proliferation IDA GO:0042129 regulation of T cell proliferation IDA

Immuno Process:  Barrier integrity GO Annotations:  Associated to 2 GO processes, IEA only GO:0001618 virus receptor activity IDA GO:0046718 viral entry into host cell IDA

Immuno Process:  B cell (activation) GO Annotations:  Associated to 1 GO processes, IEA only click arrow to show/hide IEA associations GO:0002250 adaptive immune response IEA

General Comments
DC-SIGN (CD209) is a pathogen-recognition receptor expressed on the surface of immature dendritic cells.