Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	678	17q21.2	DHX58	DExH-box helicase 58
Mouse	-	678	11 D; 11 63.52 cM	Dhx58	DExH-box helicase 58
Rat	-	678	10q31	Dhx58	DEXH-box helicase 58

Previous and Unofficial Names

DEXH (Asp-Glu-X-His) box polypeptide 58 | RNA helicase LGP2

Database Links
Alphafold	Q96C10 (Hs)
BRENDA	3.6.4.13
Ensembl Gene	ENSG00000108771 (Hs), ENSMUSG00000017830 (Mm), ENSRNOG00000018247 (Rn)
Entrez Gene	79132 (Hs), 80861 (Mm), 303538 (Rn)
Human Protein Atlas	ENSG00000108771 (Hs)
KEGG Enzyme	3.6.4.13
KEGG Gene	hsa:79132 (Hs), mmu:80861 (Mm), rno:303538 (Rn)
OMIM	608588 (Hs)
Pharos	Q96C10 (Hs)
RefSeq Nucleotide	NM_024119 (Hs), NM_030150 (Mm), NM_001098788 (Rn)
RefSeq Protein	NP_077024 (Hs), NP_084426 (Mm), NP_001092258 (Rn)
UniProtKB	Q96C10 (Hs)
Wikipedia	DHX58 (Hs)

Enzyme Reaction
EC Number: 3.6.4.13 Description Reaction Reference RNA helicase: uses the energy from ATP hydrolysis to unwind RNA ATP + H(2)O <=> ADP + phosphate

Immunopharmacology Comments

LGP2 binds RNA but does not participate in the signaling pathway that RIG-1 and MDA5 are part of, and is assumed to provide a negative feedback for IFNβ induction by sequestering pathogen-derived RNA.

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Immune regulation

Immuno Process:  Cytokine production & signalling

Immuno Process:  Cellular signalling