Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	678	17q21.2	DHX58	DExH-box helicase 58
Mouse	-	678	11 D; 11 63.52 cM	Dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58
Rat	-	678	10q31	Dhx58	DEXH-box helicase 58

Previous and Unofficial Names

DEXH (Asp-Glu-X-His) box polypeptide 58 | RNA helicase LGP2

Database Links
Alphafold	Q96C10 (Hs)
BRENDA	3.6.4.13
Ensembl Gene	ENSG00000108771 (Hs), ENSMUSG00000017830 (Mm), ENSRNOG00000018247 (Rn)
Entrez Gene	79132 (Hs), 80861 (Mm), 303538 (Rn)
Human Protein Atlas	ENSG00000108771 (Hs)
KEGG Enzyme	3.6.4.13
KEGG Gene	hsa:79132 (Hs), mmu:80861 (Mm), rno:303538 (Rn)
OMIM	608588 (Hs)
Pharos	Q96C10 (Hs)
RefSeq Nucleotide	NM_024119 (Hs), NM_030150 (Mm), NM_001098788 (Rn)
RefSeq Protein	NP_077024 (Hs), NP_084426 (Mm), NP_001092258 (Rn)
UniProtKB	Q96C10 (Hs)
Wikipedia	DHX58 (Hs)

Enzyme Reaction
EC Number: 3.6.4.13 Description Reaction Reference RNA helicase: uses the energy from ATP hydrolysis to unwind RNA ATP + H(2)O <=> ADP + phosphate

Immunopharmacology Comments

LGP2 binds RNA but does not participate in the signaling pathway that RIG-1 and MDA5 are part of, and is assumed to provide a negative feedback for IFNβ induction by sequestering pathogen-derived RNA.

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 7 GO processes GO:0039534 negative regulation of MDA-5 signaling pathway IMP GO:0039536 negative regulation of RIG-I signaling pathway IDA GO:0045087 innate immune response IBA GO:0045088 regulation of innate immune response IDA GO:0045824 negative regulation of innate immune response IDA GO:1900245 positive regulation of MDA-5 signaling pathway ISS GO:1900246 positive regulation of RIG-I signaling pathway ISS

Immuno Process:  Immune regulation GO Annotations:  Associated to 6 GO processes GO:0039534 negative regulation of MDA-5 signaling pathway IMP GO:0039536 negative regulation of RIG-I signaling pathway IDA GO:0045088 regulation of innate immune response IDA GO:0045824 negative regulation of innate immune response IDA GO:1900245 positive regulation of MDA-5 signaling pathway ISS GO:1900246 positive regulation of RIG-I signaling pathway ISS

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 7 GO processes GO:0032480 negative regulation of type I interferon production IDA GO:0032481 positive regulation of type I interferon production ISS GO:0032728 positive regulation of interferon-beta production IBA GO:0039534 negative regulation of MDA-5 signaling pathway IMP GO:0039536 negative regulation of RIG-I signaling pathway IDA GO:1900245 positive regulation of MDA-5 signaling pathway ISS GO:1900246 positive regulation of RIG-I signaling pathway ISS

Immuno Process:  Cellular signalling GO Annotations:  Associated to 4 GO processes GO:0039534 negative regulation of MDA-5 signaling pathway IMP GO:0039536 negative regulation of RIG-I signaling pathway IDA GO:1900245 positive regulation of MDA-5 signaling pathway ISS GO:1900246 positive regulation of RIG-I signaling pathway ISS