Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	925	9p21.1	RIGI	RNA sensor RIG-I
Mouse	-	926	4 A5	Rigi	RNA sensor RIG-I
Rat	-	598	5q22	Rig1	RNA sensor RIG-1

Previous and Unofficial Names

DEAD/H box helicase 58 | DDX58 | Ddx58 | DEXD/H-box helicase 58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | retinoic acid inducible gene I | RNA helicase RIG-I

Database Links
Alphafold	O95786 (Hs), Q6Q899 (Mm)
BRENDA	3.6.4.13
Ensembl Gene	ENSG00000107201 (Hs), ENSMUSG00000040296 (Mm), ENSRNOG00000006384 (Rn)
Entrez Gene	23586 (Hs), 230073 (Mm), 297989 (Rn)
Human Protein Atlas	ENSG00000107201 (Hs)
KEGG Enzyme	3.6.4.13
KEGG Gene	hsa:23586 (Hs), mmu:230073 (Mm), rno:297989 (Rn)
OMIM	609631 (Hs)
Pharos	O95786 (Hs)
RefSeq Nucleotide	NM_014314 (Hs), NM_172689 (Mm), NM_001106645 (Rn)
RefSeq Protein	NP_055129 (Hs), NP_766277 (Mm), NP_001100115 (Rn)
UniProtKB	O95786 (Hs), Q6Q899 (Mm)
Wikipedia	RIGI (Hs)

Enzyme Reaction
EC Number: 3.6.4.13 Description Reaction Reference RNA helicase: uses the energy from ATP hydrolysis to unwind RNA ATP + H(2)O <=> ADP + phosphate

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference SLR14 Hs Agonist - - 1 ⤷ [1]

Immunopharmacology Comments

RIG-I is an intracellular sensor that responds to viral nucleic acids and activates downstream signaling, resulting in the induction of the type I interferon response [2]. RIG-I recognizes RNAs from more that 25 viruses and can detect dsRNAs, ssRNAs harboring a 5′-triphosphate and blunt-ended 5′-triphosphate-containing dsRNAs. Dysregulated RIG-I signaling has been associated with autoimmune disorders [2].

Immuno Process Associations

Immuno Process:  Inflammation GO Annotations:  Associated to 3 GO processes GO:0039529 RIG-I signaling pathway IDA GO:0045087 innate immune response IMP GO:0140374 antiviral innate immune response IDA

Immuno Process:  Immune regulation GO Annotations:  Associated to 2 GO processes GO:0002735 positive regulation of myeloid dendritic cell cytokine production ISS GO:0039529 RIG-I signaling pathway IDA

Immuno Process:  Cytokine production & signalling GO Annotations:  Associated to 10 GO processes GO:0002735 positive regulation of myeloid dendritic cell cytokine production ISS GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production IDA GO:0032727 positive regulation of interferon-alpha production IDA GO:0032728 positive regulation of interferon-beta production IDA GO:0032755 positive regulation of interleukin-6 production IDA GO:0032757 positive regulation of interleukin-8 production IDA GO:0032760 positive regulation of tumor necrosis factor production IMP GO:0034344 regulation of type III interferon production TAS GO:0039529 RIG-I signaling pathway IDA GO:0060760 positive regulation of response to cytokine stimulus IMP

Immuno Process:  Cellular signalling GO Annotations:  Associated to 1 GO processes GO:0039529 RIG-I signaling pathway IDA

Physiological Consequences of Altering Gene Expression
Conventional dendritic cells (cDCs), macrophages and fibroblasts isolated from RIG-1 null mice have impaired IFN induction after RNA virus infection. Plasmacytoid DCs are unaffected by RIG-1 knockout, suggesting nucleic acid sensing TLRs are more relevant in these cells. Species:  Mouse Tissue:  cDCs, macrophages and fibroblasts, Technique:  References: