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Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 668 | 11q12.2 | CD6 | CD6 molecule | |
Mouse | 1 | 665 | 19 7.16 cM | Cd6 | CD6 antigen | |
Rat | - | 665 | 1q43 | Cd6 | Cd6 molecule | |
Gene and Protein Information Comments | ||||||
Details of alternate transcripts and protein isoforms identified for human and mouse CD6 are available from their NCBI (Entrez) gene entries. |
Previous and Unofficial Names |
Tp120 |
Database Links | |
Alphafold | P30203 (Hs), Q61003 (Mm) |
CATH/Gene3D | 3.10.250.10 |
ChEMBL Target | CHEMBL3712853 (Hs) |
Ensembl Gene | ENSG00000013725 (Hs), ENSMUSG00000024670 (Mm), ENSRNOG00000020884 (Rn) |
Entrez Gene | 923 (Hs), 12511 (Mm), 25752 (Rn) |
Human Protein Atlas | ENSG00000013725 (Hs) |
KEGG Gene | hsa:923 (Hs), mmu:12511 (Mm), rno:25752 (Rn) |
Pharos | P30203 (Hs) |
RefSeq Nucleotide | NM_006725 (Hs), NM_009852 (Mm), NM_175577 (Rn) |
RefSeq Protein | NP_006716 (Hs), NP_033982 (Mm), NP_783167 (Rn) |
UniProtKB | P30203 (Hs), Q61003 (Mm) |
Wikipedia | CD6 (Hs) |
Download all structure-activity data for this target as a CSV file
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Immunopharmacology Comments |
CD6 is a co-stimulatory molecule, predominantly expressed on lymphocytes and associated with autoimmune responses. CD6 interacts with activated leucocyte-cell adhesion molecule (ALCAM/CD166), found on antigen presenting cells. This interaction induces the production of proinflammatory cytokines [2], prostaglandins, leukotrienes and oxygen free radicals. Druggability is indicated by approval of the anti-CD6 monoclonal antibody itolizumab to treat psoriasis. |
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1. Alonso R, Huerta V, de Leon J, Piedra P, Puchades Y, Guirola O, Chinea G, Montero E. (2008) Towards the definition of a chimpanzee and human conserved CD6 domain 1 epitope recognized by T1 monoclonal antibody. Hybridoma (Larchmt), 27 (4): 291-301. [PMID:18707547]
2. Nair P, Melarkode R, Rajkumar D, Montero E. (2010) CD6 synergistic co-stimulation promoting proinflammatory response is modulated without interfering with the activated leucocyte cell adhesion molecule interaction. Clin Exp Immunol, 162 (1): 116-30. [PMID:20726988]
CD molecules: CD6. Last modified on 06/02/2017. Accessed on 11/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2917.