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heat shock protein 90 alpha family class B member 1

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Target id: 2907

Nomenclature: heat shock protein 90 alpha family class B member 1

Abbreviated Name: HSP90AB1

Family: Heat shock proteins

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 724 6p21.1 HSP90AB1 heat shock protein 90 alpha family class B member 1
Mouse - 724 17 22.59 cM Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1
Rat - 724 9q12 Hsp90ab1 heat shock protein 90 alpha family class B member 1
Previous and Unofficial Names Click here for help
HSP90AB1 | HSp90AB1 | heat shock protein 90 alpha (cytosolic), class B member 1 | heat shock protein 90 alpha (cytosolic)
Database Links Click here for help
Alphafold P08238 (Hs), P11499 (Mm), P34058 (Rn)
CATH/Gene3D 3.30.565.10
ChEMBL Target CHEMBL4303 (Hs)
Ensembl Gene ENSG00000096384 (Hs), ENSMUSG00000023944 (Mm), ENSRNOG00000019834 (Rn)
Entrez Gene 3326 (Hs), 15516 (Mm), 301252 (Rn)
Human Protein Atlas ENSG00000096384 (Hs)
KEGG Gene hsa:3326 (Hs), mmu:15516 (Mm), rno:301252 (Rn)
Pharos P08238 (Hs)
RefSeq Nucleotide NM_007355 (Hs), NM_008302 (Mm), NM_001004082 (Rn)
RefSeq Protein NP_031381 (Hs), NP_032328 (Mm), NP_001004082 (Rn)
UniProtKB P08238 (Hs), P11499 (Mm), P34058 (Rn)
Wikipedia HSP90AB1 (Hs)

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
luminespib Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.7 pIC50
⤷ pIC50 8.7 (IC50 2x10-9 M)
geldanamycin Small molecule or natural product Ligand has a PDB structure Hs Inhibition 6.6 pIC50 2
⤷ pIC50 6.6 (IC50 2.82x10-7 M) [2]
Immunopharmacology Comments
HSP90AB1 chaperones both JAK2 and PRKCE, and by ensuring proper folding of these kinase proteins it is involved in the phosphorylation/activation of STAT1 [1]. This tangential function in JAK/STAT signalling indicates a potential role for HSP90AB1 in inflammation and the immune response.
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Immune regulation
Immuno Process:  Cytokine production & signalling
Immuno Process:  Cellular signalling

References

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1. Cheng MB, Zhang Y, Zhong X, Sutter B, Cao CY, Chen XS, Cheng XK, Zhang Y, Xiao L, Shen YF. (2010) Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response. Cell Signal, 22 (8): 1206-13. [PMID:20353823]

2. Gavenonis J, Jonas NE, Kritzer JA. (2014) Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix. Bioorg Med Chem, 22 (15): 3989-93. [PMID:24984936]

How to cite this page

Heat shock proteins: heat shock protein 90 alpha family class B member 1. Last modified on 29/10/2018. Accessed on 11/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2907.