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Target id: 2896
Nomenclature: leukocyte immunoglobulin like receptor A4 (CD85g)
Abbreviated Name: LILRA4
Family: CD molecules
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 499 | 19q13.42 | LILRA4 | leukocyte immunoglobulin like receptor A4 | |
Gene and Protein Information Comments | ||||||
The LILRA4 protein is translated as a 499 amino acid precursor. The 23 amino terminal residues are a signal peptide, cleaved to form the mature protein. The protein structure has several disulphide bonds, and is heavily glycosylated. |
Previous and Unofficial Names |
leucocyte Ig-like receptor A4 | ILT7 | immunoglobulin-like transcript 7 |
Database Links | |
Alphafold | P59901 (Hs) |
CATH/Gene3D | 2.60.40.10 |
ChEMBL Target | CHEMBL4804246 (Hs) |
Ensembl Gene | ENSG00000239961 (Hs) |
Entrez Gene | 23547 (Hs) |
Human Protein Atlas | ENSG00000239961 (Hs) |
KEGG Gene | hsa:23547 (Hs) |
OMIM | 607517 (Hs) |
Pharos | P59901 (Hs) |
RefSeq Nucleotide | NM_012276 (Hs) |
RefSeq Protein | NP_036408 (Hs) |
UniProtKB | P59901 (Hs) |
Wikipedia | LILRA4 (Hs) |
Download all structure-activity data for this target as a CSV file
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Immunopharmacology Comments |
LILRA4 (CD85g) is a member of the activating leukocyte immunoglobulin like receptor (LILRA) family (HGNC family 1181). It is involved in activation of eosinophils and homeostatic regulation of the innate immunity of plasmacytoid dendritic cells (pDCs) [1]. Anti-ILT7 antibody was developed to target CD85g +ve IFNα-producing pDCs as a novel mechanism for the treatment of autoimmune condtions [4]. |
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Gene Expression and Pathophysiology Comments | |
LILRA4 (ILT7) is a marker of plasmacytoid dendritic cells (pDCs), cells which are reported to be a major source of the abnormally high levels of IFNα associated with autoimmune diseases. Targeting LILRA4 with therapeutic antibodies to promote killing of these IFNα-producing pDCs is being investigated as a novel approach to alleviating the symptoms of autoimmune diseases. |
General Comments |
LILRA4 is an immunoglobulin-like protein preferentially expressed on the surface of human plasmacytoid dendritic cells (pDCs) [1]. It interacts with bone marrow stromal cell antigen 2 (BST2; CD317; Q10589) to control the Toll-like receptor (TLR) driven response by pDCs to viral infection. It may also be involved in modulating pDC-tumour interactions. pDCs are a source of the excess IFNα which drives autoimmune disease symptoms. |
1. Cao W, Bover L. (2010) Signaling and ligand interaction of ILT7: receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells. Immunol Rev, 234 (1): 163-76. [PMID:20193018]
2. Cao W, Rosen DB, Ito T, Bover L, Bao M, Watanabe G, Yao Z, Zhang L, Lanier LL, Liu YJ. (2006) Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production. J Exp Med, 203 (6): 1399-405. [PMID:16735691]
3. Cho M, Ishida K, Chen J, Ohkawa J, Chen W, Namiki S, Kotaki A, Arai N, Arai K, Kamogawa-Schifter Y. (2008) SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production. Int Immunol, 20 (1): 155-64. [PMID:18048391]
4. Kamogawa Y, Cho M, Arai N, Ishida K. (2011) Anti-ILT7 antibody. Patent number: US8084585 B2. Assignee: Sbi Biotech Co., Ltd.. Priority date: 20/10/2005. Publication date: 27/12/2011.
5. Rissoan MC, Duhen T, Bridon JM, Bendriss-Vermare N, Péronne C, de Saint Vis B, Brière F, Bates EE. (2002) Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells. Blood, 100 (9): 3295-303. [PMID:12384430]
CD molecules: leukocyte immunoglobulin like receptor A4 (CD85g). Last modified on 06/12/2017. Accessed on 03/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2896.