Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	229	17q23.3	CD79B	CD79b molecule
Mouse	1	228	11 68.89 cM	Cd79b	CD79B antigen
Rat	1	228	10q32.1	Cd79b	CD79b molecule
Gene and Protein Information Comments
The table lists the longest isoform of human CD79B, shorter isoforms are reported.

Previous and Unofficial Names

immunoglobulin-associated beta | IGB | CD79b molecule, immunoglobulin-associated beta | Cd79b molecule, immunoglobulin-associated beta

Database Links
Alphafold	P40259 (Hs), P15530 (Mm)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL3712852 (Hs)
Ensembl Gene	ENSG00000007312 (Hs), ENSMUSG00000040592 (Mm), ENSRNOG00000011917 (Rn)
Entrez Gene	974 (Hs), 15985 (Mm), 171055 (Rn)
Human Protein Atlas	ENSG00000007312 (Hs)
KEGG Gene	hsa:974 (Hs), mmu:15985 (Mm), rno:171055 (Rn)
OMIM	147245 (Hs)
Pharos	P40259 (Hs)
RefSeq Nucleotide	NM_001039933 (Hs), NM_008339 (Mm), NM_133533 (Rn)
RefSeq Protein	NP_001035022 (Hs), NP_032365 (Mm), NP_598217 (Rn)
UniProtKB	P40259 (Hs), P15530 (Mm)
Wikipedia	CD79B (Hs)

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols		Click column headers to sort
Antibody Sp. Action Value Parameter Reference polatuzumab vedotin Hs Binding - - 1 ⤷ [1]
Antibody Comments
The ADC iladatuzumab vedotin (DCDS0780A) is being developed by Hoffmann-La Roche for potential treatment of B-cell non-Hodgkin's lymphoma. It is being evaluated in Phase 1 clinical trial NCT02453087.

Immunopharmacology Comments

CD79B is a component of the multimeric B cell antigen receptor (along with CD79A and a membrane-bound antibody that acts as the antigen recognition moiety). The CD79A/B component is responsible for signal transduction. The B cell antigen receptor complex is reported to be involved in the pathogenesis of various B cell-derived lymphoid cancers [2-3]. Inhibitors of components of B cell receptor signalling are being pursued as novel therapeutics for lymphoid neoplasms, e.g.polatuzumab vedotin is an investigational antibody-drug conjugate targeting a toxic payload to CD79B +ve cells in various hematological malignancies.

Cell Type Associations

Immuno Cell Type:  B cells

Immuno Process Associations

Immuno Process:  B cell (activation)

Immuno Process:  Immune regulation

Immuno Process:  Immune system development

Immuno Process:  Cellular signalling

Immuno Process:  T cell (activation)

Clinically-Relevant Mutations and Pathophysiology
Disease:  Agammaglobulinemia 6, Autosomal recessive; AGM6 Synonyms: Agammaglobulinemia [Disease Ontology: DOID:2583] Autosomal agammaglobulinemia [Orphanet: ORPHA33110] Disease Ontology: DOID:2583 OMIM: 612692 Orphanet: ORPHA33110

General Comments
This protein contains an immunoglobulin (Ig)-like domain that resembles the antibody variable domain, that has been coined the 'V-set domain'. The genes for all human V-set domain containing proteins are listed in HGNC gene group 590.