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tumor associated calcium signal transducer 2

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Target id: 2837

Nomenclature: tumor associated calcium signal transducer 2

Family: Tumour-associated antigens

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 323 1p32.1 TACSTD2 tumor associated calcium signal transducer 2
Mouse 1 317 6 C1 Tacstd2 tumor-associated calcium signal transducer 2
Rat 1 317 4q31 Tacstd2 tumor-associated calcium signal transducer 2
Previous and Unofficial Names Click here for help
GA733-1 | RS7 antigen [4] | M1S1 | EGP-1 | TROP2 | TROP-2 | tumor-associated calcium signal transducer 2
Database Links Click here for help
Alphafold P09758 (Hs), Q8BGV3 (Mm), Q6P9Z6 (Rn)
CATH/Gene3D 4.10.800.10
ChEMBL Target CHEMBL3856163 (Hs)
Ensembl Gene ENSG00000184292 (Hs), ENSMUSG00000051397 (Mm), ENSRNOG00000007740 (Rn)
Entrez Gene 4070 (Hs), 56753 (Mm), 494343 (Rn)
Human Protein Atlas ENSG00000184292 (Hs)
KEGG Gene hsa:4070 (Hs), mmu:56753 (Mm), rno:494343 (Rn)
OMIM 137290 (Hs)
Pharos P09758 (Hs)
RefSeq Nucleotide NM_002353 (Hs), NM_020047 (Mm), NM_001009540 (Rn)
RefSeq Protein NP_002344 (Hs), NP_064431 (Mm), NP_001009540 (Rn)
UniProtKB P09758 (Hs), Q8BGV3 (Mm), Q6P9Z6 (Rn)
Wikipedia TACSTD2 (Hs)

Download all structure-activity data for this target as a CSV file go icon to follow link

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Value Parameter Reference
sacituzumab govitecan Peptide Approved drug Primary target of this compound Hs Binding 9.5 pKd 1-2
⤷ pKd 9.5 (Kd 2.9x10-10 M) [1-2]
Description: Binding affinity determined by SPR
sacituzumab tirumotecan Peptide Approved drug Hs Binding 9.5 pKd 1
⤷ pKd 9.5 (Kd 3.1x10-10 M) [1]
Description: Binding affinity determined by SPR
hIMB1636-MMAE Peptide Hs Binding 9.1 pKd 5
⤷ pKd 9.1 (Kd 7x10-10 M) [5]
Description: Binding affinity for recombinant antigen
datopotamab deruxtecan Peptide Approved drug Hs Binding - - 3
⤷ [3]
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Corneal dystrophy, gelatinous drop-like; GDLD
Synonyms: Gelatinous drop-like corneal dystrophy [Orphanet: ORPHA98957]
OMIM: 204870
Orphanet: ORPHA98957
Disease:  Honey-droplet corneal dystrophy
Orphanet: ORPHA98958
General Comments
TROP2 is an antigen that is overexpressed on the surface of tumours of the lung, breast, pancreas and other organs. Elevated TROP2 expression is associated with poor prognosis. The first anti-TROP2 ADC to be approved was Immunomedics' sacituzumab govitecan (Trodelvy®) in April 2020. AstraZeneca, in partnership with Daiichi Sankyo, progressed their anti-TROP2 ADC datopotamab deruxtecan (DS-1062) through to approval in 2025.

References

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1. Cheng Y, Yuan X, Tian Q, Huang X, Chen Y, Pu Y, Long H, Xu M, Ji Y, Xie J et al.. (2022) Preclinical profiles of SKB264, a novel anti-TROP2 antibody conjugated to topoisomerase inhibitor, demonstrated promising antitumor efficacy compared to IMMU-132. Front Oncol, 12: 951589. [PMID:36620535]

2. Govindan SV, Qu Z, Hansen HJ, Goldenberg DM. (2013) RS7 antibodies. Patent number: US8574575. Assignee: Immunomedics, Inc.. Priority date: 01/03/2002. Publication date: 05/11/2013.

3. Schipilliti FM, Drittone D, Mazzuca F, La Forgia D, Guven DC, Rizzo A. (2024) Datopotamab deruxtecan: A novel antibody drug conjugate for triple-negative breast cancer. Heliyon, 10 (7): e28385. [PMID:38560142]

4. Stein R, Basu A, Goldenberg DM, Lloyd KO, Mattes MJ. (1994) Characterization of cluster 13: the epithelial/carcinoma antigen recognized by MAb RS7. Int J Cancer Suppl, 8: 98-102. [PMID:8194903]

5. Sun LP, Bai WQ, Zhou DD, Wu XF, Zhang LW, Cui AL, Xie ZH, Gao RJ, Zhen YS, Li ZR et al.. (2023) hIMB1636-MMAE, a Novel TROP2-Targeting Antibody-Drug Conjugate Exerting Potent Antitumor Efficacy in Pancreatic Cancer. J Med Chem, 66 (21): 14700-14715. [PMID:37883180]

How to cite this page

Tumour-associated antigens: tumor associated calcium signal transducer 2. Last modified on 10/03/2025. Accessed on 25/04/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2837.