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L3MBTL histone methyl-lysine binding protein 3

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Target id: 2830

Nomenclature: L3MBTL histone methyl-lysine binding protein 3

Family: Methyllysine reader proteins

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 780 6q23.1 L3MBTL3 L3MBTL histone methyl-lysine binding protein 3
Mouse - 883 10 A4 L3mbtl3 L3MBTL3 histone methyl-lysine binding protein
Rat - - 1p12 L3mbtl3 L3MBTL histone methyl-lysine binding protein 3
Gene and Protein Information Comments
A shorter isoform of human L3MBTL3 (isoform b, 755 amino acids; NP_001007103) is reported.
Previous and Unofficial Names Click here for help
L3MBTL3 | L3MBTL3, histone methyl-lysine binding protein | l(3)mbt-like 3 (Drosophila) | lethal(3)malignant brain tumor-like protein 3 | MBT-1 | MBT1
Database Links Click here for help
Alphafold
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures Click here for help
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of the complex of the 3-MBT repeat domain of L3MBTL3 and UNC1215
PDB Id:  4FL6
Ligand:  UNC1215
Resolution:  2.55Å
Species:  Human
References: 

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Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
UNC1215 Small molecule or natural product Primary target of this compound Ligand has a PDB structure Hs Agonist 6.9 pKd 1
pKd 6.9 (Kd 1.2x10-7 M) [1]
Immuno Process Associations
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0043249 erythrocyte maturation IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 4 GO processes, IEA only
GO:0030099 myeloid cell differentiation IMP
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GO:0030225 macrophage differentiation IEA
GO:0030851 granulocyte differentiation IEA
GO:0043249 erythrocyte maturation IEA

References

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1. James LI, Barsyte-Lovejoy D, Zhong N, Krichevsky L, Korboukh VK, Herold JM, MacNevin CJ, Norris JL, Sagum CA, Tempel W et al.. (2013) Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol, 9 (3): 184-91. [PMID:23292653]

How to cite this page

Methyllysine reader proteins: L3MBTL histone methyl-lysine binding protein 3. Last modified on 27/03/2019. Accessed on 04/12/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2830.