Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	15	1549	12p12.1	ABCC9	ATP binding cassette subfamily C member 9
Mouse	15	1546	6 74.35 cM	Abcc9	ATP-binding cassette, sub-family C member 9
Rat	15	1545	4q44	Abcc9	ATP binding cassette subfamily C member 9

Previous and Unofficial Names

CDMD10 | sulfonylurea receptor 2 | SUR2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | ATP-binding cassette, subfamily C (CFTR/MRP), member 9 | ATP-binding cassette

Database Links
Alphafold	O60706 (Hs), P70170 (Mm), Q63563 (Rn)
ChEMBL Target	CHEMBL1971 (Hs), CHEMBL3244 (Rn)
Ensembl Gene	ENSG00000069431 (Hs), ENSMUSG00000030249 (Mm), ENSRNOG00000036960 (Rn)
Entrez Gene	10060 (Hs), 20928 (Mm), 25560 (Rn)
Human Protein Atlas	ENSG00000069431 (Hs)
KEGG Gene	hsa:10060 (Hs), mmu:20928 (Mm), rno:25560 (Rn)
OMIM	601439 (Hs)
Pharos	O60706 (Hs)
RefSeq Nucleotide	NM_020297 (Hs), NM_005691 (Hs), NM_011511 (Mm), NM_013040 (Rn)
RefSeq Protein	NP_005682 (Hs), NP_064693 (Hs), NP_035641 (Mm), NP_037172 (Rn)
UniProtKB	O60706 (Hs), P70170 (Mm), Q63563 (Rn)
Wikipedia	ABCC9 (Hs)

Download all structure-activity data for this target as a CSV file

Allosteric Modulators
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 13b [PMID: 19101153] Hs Positive 6.2 pEC50 2 ⤷ pEC50 6.2 (EC50 6.7x10-7 M) Compound 13b is a channel opener. [2]
Allosteric Modulator Comments
Compound 13b [PMID: 19101153] is most likely to bind the SUR2 [1] component of the ATP-sensitive potassium channel on smooth muscle cells, causing increased channel opening and cellular hyperpolarisation.

Clinically-Relevant Mutations and Pathophysiology
Disease:  Atrial fibrillation, familial, 12; ATFB12 Synonyms: Familial atrial fibrillation [Orphanet: ORPHA334] [Disease Ontology: DOID:0050650] Disease Ontology: DOID:0050650 OMIM: 614050 Orphanet: ORPHA334
Disease:  Cantu Syndrome Synonyms: Hypertrichotic osteochondrodysplasia, Cantu type [Orphanet: ORPHA1517] OMIM: 239850 Orphanet: ORPHA1517
Disease:  Cardiomyopathy, dilated, 1O; CMD1O Synonyms: Dilated cardiomyopathy [Disease Ontology: DOID:12930] Familial isolated dilated cardiomyopathy [Orphanet: ORPHA154] Disease Ontology: DOID:12930 OMIM: 608569 Orphanet: ORPHA154