Gene and Protein Information
class C G protein-coupled receptor
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	7	403	16p12.3	GPRC5B	G protein-coupled receptor class C group 5 member B	1,4
Mouse	7	410	7 F2	Gprc5b	G protein-coupled receptor, family C, group 5, member B	3
Rat	7	394	1q35	Gprc5b	G protein-coupled receptor, class C, group 5, member B

Previous and Unofficial Names

RAIG2 | retinoic acid-induced gene 2 protein | G protein-coupled receptor, class C, group 5, member B | G protein-coupled receptor

Database Links
Alphafold	Q9NZH0 (Hs), Q923Z0 (Mm)
ChEMBL Target	CHEMBL4523926 (Hs)
Ensembl Gene	ENSG00000167191 (Hs), ENSMUSG00000008734 (Mm), ENSRNOG00000016013 (Rn)
Entrez Gene	51704 (Hs), 64297 (Mm), 293546 (Rn)
Human Protein Atlas	ENSG00000167191 (Hs)
KEGG Gene	hsa:51704 (Hs), mmu:64297 (Mm), rno:293546 (Rn)
OMIM	605948 (Hs)
Pharos	Q9NZH0 (Hs)
RefSeq Nucleotide	NM_016235 (Hs), NM_022420 (Mm), NM_001106304 (Rn)
RefSeq Protein	NP_057319 (Hs), NP_071865 (Mm), NP_001099774 (Rn)
UniProtKB	Q9NZH0 (Hs), Q923Z0 (Mm)
Wikipedia	GPRC5B (Hs)

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Immune regulation

Immuno Process:  Cytokine production & signalling

Tissue Distribution
High expression in adult kidney, pancreas and testis. Medium expression in adult brain, heart, prostate, small intestine and spleen. Low expression in adult liver, placenta, skeletal muscle, colon, ovary and thymus. Not detectable in adult lung and peripheral leukocyte. Species:  Human Technique:  RT-PCR References:  2
High expression in adult brain and spinal cord. Medium to low expression in adult pancreas, testis, uterus and stomach. Species:  Human Technique:  RT-PCR References:  4

Expression Datasets
Show »« Hide Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website] There should be a chart of expression data here, you may need to enable JavaScript!

General Comments
Orphan receptor. mRNA expression is induced by retinoic acid in some cell lines.