Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	535	6p22.3	ALDH5A1	aldehyde dehydrogenase 5 family member A1
Mouse	-	523	13 10.77 cM	Aldh5a1	aldhehyde dehydrogenase family 5, subfamily A1
Rat	-	523	17p11	Aldh5a1	aldehyde dehydrogenase 5 family, member A1

Previous and Unofficial Names

NAD(+)-dependent succinic semialdehyde dehydrogenase | SSADH, SSDH | succinate-semialdehyde dehydrogenase, mitochondrial | aldehyde dehydrogenase 5 family, member A1 | aldehyde dehydrogenase 5 family | aldhehyde dehydrogenase family 5, subfamily A1 | aldhehyde dehydrogenase family 5

Database Links
Alphafold	P51649 (Hs), Q8BWF0 (Mm), G3V945 (Rn)
BRENDA	1.2.1.24
CATH/Gene3D	3.40.605.10
ChEMBL Target	CHEMBL1911 (Hs)
Ensembl Gene	ENSG00000112294 (Hs), ENSMUSG00000035936 (Mm), ENSRNOG00000023538 (Rn)
Entrez Gene	7915 (Hs), 214579 (Mm), 291133 (Rn)
Human Protein Atlas	ENSG00000112294 (Hs)
KEGG Enzyme	1.2.1.24
KEGG Gene	hsa:7915 (Hs), mmu:214579 (Mm), rno:291133 (Rn)
OMIM	610045 (Hs)
Pharos	P51649 (Hs)
RefSeq Nucleotide	NM_001080 (Hs), NM_170740 (Hs), NM_172532 (Mm), NM_022851 (Rn)
RefSeq Protein	NP_733936 (Hs), NP_001071 (Hs), NP_766120 (Mm), NP_074042 (Rn)
UniProtKB	P51649 (Hs), Q8BWF0 (Mm), G3V945 (Rn)
Wikipedia	ALDH5A1 (Hs)

Enzyme Reaction
EC Number: 1.2.1.24 4-Oxobutanoate + NAD + H2O = succinic acid + NADH + 2H+ 4-hydroxy-trans-2-nonenal + NAD + H2O = 4-hydroxy-trans-2-nonenoate + NADH + 2H+

Cofactors
Cofactor Species Comments Reference NAD None

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference 4-acryloylphenol Hs Inhibition 6.5 pIC50 1 ⤷ pIC50 6.5 (IC50 3.5x10-7 M) [1]
Inhibitor Comments
This enzyme is inhibited by the approved drug valproic acid.

Clinically-Relevant Mutations and Pathophysiology
Disease:  Succinic semialdehyde dehydrogenase deficiency; SSADHD Synonyms: 4-hydroxybutyric aciduria [Orphanet: ORPHA22] Disease Ontology: DOID:0060175 OMIM: 271980 Orphanet: ORPHA22