Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	304	9p13.3	PRSS3	serine protease 3
Mouse	-	246	6 B1	Prss3	serine protease 3
Rat	-	-	q22	LOC679835	similar to Anionic trypsin II precursor (Pretrypsinogen II)

Previous and Unofficial Names

mesotrypsin | MTG | protease | protease, serine, 3 | protease, serine 3 | PRSS4 | Try3 | TRY4 | trypsin 3 | trypsinogen 15

Database Links
Specialist databases
MEROPS	S01.174 (Hs)
Other databases
Alphafold	P35030 (Hs)
BRENDA	3.4.21.4
ChEMBL Target	CHEMBL4551 (Hs)
Ensembl Gene	ENSG00000010438 (Hs), ENSMUSG00000071519 (Mm)
Entrez Gene	5646 (Hs), 22073 (Mm), 679835 (Rn)
Human Protein Atlas	ENSG00000010438 (Hs)
KEGG Enzyme	3.4.21.4
KEGG Gene	hsa:5646 (Hs), mmu:22073 (Mm), rno:679835 (Rn)
OMIM	613578 (Hs)
Pharos	P35030 (Hs)
RefSeq Nucleotide	NM_007343 (Hs), NM_001197097 (Hs), NM_002771 (Hs), NM_011645 (Mm)
RefSeq Protein	NP_031369 (Hs), NP_001184026 (Hs), NP_002762 (Hs), NP_035775 (Mm)
UniProtKB	P35030 (Hs)
Wikipedia	PRSS3 (Hs)

Enzyme Reaction
EC Number: 3.4.21.4

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference BPTI-K15R/R17G Hs Inhibition 8.2 pKi 1 ⤷ pKi 8.2 (Ki 5.9x10-9 M) [1]
Inhibitor Comments
BPTI-K15R/R17G retains inhibitory activity towards human cationic trypsin and human anionic trypsin, but activity is weakened compared to wild type BPTI [1].

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Cellular signalling