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peptidase D

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Target id: 2389

Nomenclature: peptidase D

Family: M24: Methionyl aminopeptidase

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 493 19q13.11 PEPD peptidase D
Mouse - 493 7 20.7 cM Pepd peptidase D
Rat - 492 1q21 Pepd peptidase D
Previous and Unofficial Names Click here for help
imidodipeptidase | Pep4 | peptidase 4 | prolidase | proline dipeptidase
Database Links Click here for help
Specialist databases
MEROPS M24.007 (Hs)
Other databases
Alphafold P12955 (Hs), Q11136 (Mm), Q5I0D7 (Rn)
BRENDA 3.4.13.9
CATH/Gene3D 3.40.350.10
ChEMBL Target CHEMBL4185 (Hs)
Ensembl Gene ENSG00000124299 (Hs), ENSMUSG00000063931 (Mm), ENSRNOG00000052945 (Rn)
Entrez Gene 5184 (Hs), 18624 (Mm), 292808 (Rn)
Human Protein Atlas ENSG00000124299 (Hs)
KEGG Enzyme 3.4.13.9
KEGG Gene hsa:5184 (Hs), mmu:18624 (Mm), rno:292808 (Rn)
OMIM 613230 (Hs)
Orphanet ORPHA124187 (Hs)
Pharos P12955 (Hs)
RefSeq Nucleotide NM_000285 (Hs), NM_001166057 (Hs), NM_001166056 (Hs), NM_008820 (Mm), NM_001009641 (Rn)
RefSeq Protein NP_001159529 (Hs), NP_001159528 (Hs), NP_000276 (Hs), NP_032846 (Mm), NP_001009641 (Rn)
UniProtKB P12955 (Hs), Q11136 (Mm), Q5I0D7 (Rn)
Wikipedia PEPD (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.13.9

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
phosphoenolpyruvic acid Small molecule or natural product Ligand has a PDB structure Pig Inhibition 9.5 – 9.6 pKi 1
⤷ pKi 9.5 – 9.6 (Ki 3x10-10 – 2.4x10-10 M) [1]
Description: Biphasic inhibition of purified enzyme from pig kidney.
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Prolidase deficiency
OMIM: 170100
Orphanet: ORPHA742

References

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1. Mock WA, Liu Y. (1995) Inhibition of prolidase by phosphoenolpyruvate is biphasic. avoidance of endogenous-metabolite inactivation by cooperativity within an enzyme dimer. Bioorg Med Chem Lett, 5 (6): 627-630.

How to cite this page

M24: Methionyl aminopeptidase: peptidase D. Last modified on 22/07/2015. Accessed on 27/10/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2389.