Quaternary Structure: Complexes

Interleukin-2 receptor

Interleukin-4 receptor type I

Interleukin-7 receptor

Interleukin-9 receptor

Interleukin-15 receptor

Interleukin-21 receptor

Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	369	Xq13.1	IL2RG	interleukin 2 receptor subunit gamma
Mouse	1	369	X 43.9 cM	Il2rg	interleukin 2 receptor, gamma chain
Rat	-	-	Xq31	Il2rg	interleukin 2 receptor subunit gamma

Previous and Unofficial Names

CD132 | cytokine receptor common subunit gamma | IL-2RG | interleukin 2 receptor, gamma | interleukin 2 receptor, gamma chain | interleukin 2 receptor

Database Links
Alphafold	P31785 (Hs), P34902 (Mm)
CATH/Gene3D	2.60.40.10
ChEMBL Target	CHEMBL4665588 (Hs), CHEMBL4665592 (Hs), CHEMBL2364167 (Hs)
DrugBank Target	P31785 (Hs)
Ensembl Gene	ENSG00000147168 (Hs), ENSMUSG00000031304 (Mm), ENSRNOG00000003954 (Rn)
Entrez Gene	3561 (Hs), 16186 (Mm), 140924 (Rn)
Human Protein Atlas	ENSG00000147168 (Hs)
KEGG Gene	hsa:3561 (Hs), mmu:16186 (Mm), rno:140924 (Rn)
OMIM	308380 (Hs)
Pharos	P31785 (Hs)
UniProtKB	P31785 (Hs), P34902 (Mm)
Wikipedia	IL2RG (Hs)

Immunopharmacology Comments

IL2RG is a common signal transducing subunit shared by the receptors for several different cytokines, namely the IL-2 receptor heterotrimer, the IL-4 receptor type I, the IL-7 receptor, the IL-9 receptor, the IL-15 receptor and the IL-21 receptor.

Immuno Process Associations

Immuno Process:  Cytokine production & signalling

Immuno Process:  Inflammation

Immuno Process:  B cell (activation)

Immuno Process:  Cellular signalling

Immuno Process:  Chemotaxis & migration

Immuno Process:  Immune regulation

Immuno Process:  Immune system development

Immuno Process:  T cell (activation)