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Interleukin-2 receptor subunit γ

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Target id: 2303

Nomenclature: Interleukin-2 receptor subunit γ

Family: IL-2 receptor family

Contents:

Quaternary Structure: Complexes
Interleukin-2 receptor
Interleukin-4 receptor type I
Interleukin-7 receptor
Interleukin-9 receptor
Interleukin-15 receptor
Interleukin-21 receptor
Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 369 Xq13.1 IL2RG interleukin 2 receptor subunit gamma
Mouse 1 369 X 43.9 cM Il2rg interleukin 2 receptor, gamma chain
Rat - - Xq31 Il2rg interleukin 2 receptor subunit gamma
Previous and Unofficial Names Click here for help
CD132 | cytokine receptor common subunit gamma | IL-2RG | interleukin 2 receptor, gamma | interleukin 2 receptor, gamma chain | interleukin 2 receptor
Database Links Click here for help
Alphafold P31785 (Hs), P34902 (Mm)
CATH/Gene3D 2.60.40.10
ChEMBL Target CHEMBL4665588 (Hs), CHEMBL4665592 (Hs), CHEMBL2364167 (Hs)
DrugBank Target P31785 (Hs)
Ensembl Gene ENSG00000147168 (Hs), ENSMUSG00000031304 (Mm), ENSRNOG00000003954 (Rn)
Entrez Gene 3561 (Hs), 16186 (Mm), 140924 (Rn)
Human Protein Atlas ENSG00000147168 (Hs)
KEGG Gene hsa:3561 (Hs), mmu:16186 (Mm), rno:140924 (Rn)
OMIM 308380 (Hs)
Pharos P31785 (Hs)
UniProtKB P31785 (Hs), P34902 (Mm)
Wikipedia IL2RG (Hs)
Immunopharmacology Comments
IL2RG is a common signal transducing subunit shared by the receptors for several different cytokines, namely the IL-2 receptor heterotrimer, the IL-4 receptor type I, the IL-7 receptor, the IL-9 receptor, the IL-15 receptor and the IL-21 receptor.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 7 GO processes, IEA only
GO:0004896 cytokine receptor activity IBA
GO:0019221 cytokine-mediated signaling pathway IBA
GO:0035723 interleukin-15-mediated signaling pathway IMP
GO:0042010 interleukin-15 receptor activity IDA
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GO:0035771 interleukin-4-mediated signaling pathway IEA
GO:0038110 interleukin-2-mediated signaling pathway IEA
GO:0038111 interleukin-7-mediated signaling pathway IEA
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0050766 positive regulation of phagocytosis IMP
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 2 GO processes
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GO:0002335 mature B cell differentiation IEA
GO:0045579 positive regulation of B cell differentiation IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 6 GO processes
click arrow to show/hide IEA associations
GO:0002335 mature B cell differentiation IEA
GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IEA
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IEA
GO:0033077 T cell differentiation in thymus IEA
GO:0033089 positive regulation of T cell differentiation in thymus IEA
GO:0045579 positive regulation of B cell differentiation IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 2 GO processes
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GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IEA
GO:0033089 positive regulation of T cell differentiation in thymus IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
click arrow to show/hide IEA associations
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IEA
GO:0033089 positive regulation of T cell differentiation in thymus IEA
GO:0045579 positive regulation of B cell differentiation IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 6 GO processes
click arrow to show/hide IEA associations
GO:0002335 mature B cell differentiation IEA
GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IEA
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IEA
GO:0033077 T cell differentiation in thymus IEA
GO:0033089 positive regulation of T cell differentiation in thymus IEA
GO:0045579 positive regulation of B cell differentiation IEA
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 4 GO processes
click arrow to show/hide IEA associations
GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IEA
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IEA
GO:0033077 T cell differentiation in thymus IEA
GO:0033089 positive regulation of T cell differentiation in thymus IEA

How to cite this page

IL-2 receptor family: Interleukin-2 receptor subunit γ. Last modified on 10/04/2017. Accessed on 05/06/2023. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2303.