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WNK lysine deficient protein kinase 4

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Target id: 2283

Nomenclature: WNK lysine deficient protein kinase 4

Abbreviated Name: WNK4

Family: Wnk family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1243 17q21.2 WNK4 WNK lysine deficient protein kinase 4
Mouse - 1222 11 D Wnk4 WNK lysine deficient protein kinase 4
Rat - 1222 10q31 Wnk4 WNK lysine deficient protein kinase 4
Previous and Unofficial Names Click here for help
PRKWNK4
Database Links Click here for help
Alphafold Q96J92 (Hs), Q80UE6 (Mm), Q7TPK6 (Rn)
BRENDA 2.7.11.1
ChEMBL Target CHEMBL1795196 (Hs)
Ensembl Gene ENSG00000126562 (Hs), ENSMUSG00000035112 (Mm), ENSRNOG00000020441 (Rn)
Entrez Gene 65266 (Hs), 69847 (Mm), 287715 (Rn)
Human Protein Atlas ENSG00000126562 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:65266 (Hs), mmu:69847 (Mm), rno:287715 (Rn)
OMIM 601844 (Hs)
Orphanet ORPHA120534 (Hs)
Pharos Q96J92 (Hs)
RefSeq Nucleotide NM_032387 (Hs), NM_175638 (Mm), NM_175579 (Rn)
RefSeq Protein NP_115763 (Hs), NP_783569 (Mm), NP_783169 (Rn)
UniProtKB Q96J92 (Hs), Q80UE6 (Mm), Q7TPK6 (Rn)
Wikipedia WNK4 (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.1
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Pseudohypoaldosteronism, type IIB; PHA2B
Synonyms: Pseudohypoaldosteronism [Disease Ontology: DOID:4479]
Pseudohypoaldosteronism type 2B [Orphanet: ORPHA88939]
Disease Ontology: DOID:4479
OMIM: 614491
Orphanet: ORPHA88939

How to cite this page

Wnk family: WNK lysine deficient protein kinase 4. Last modified on 13/03/2014. Accessed on 30/10/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2283.