Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	581	1p36.12	PINK1	PTEN induced kinase 1
Mouse	1	580	4 D3	Pink1	PTEN induced putative kinase 1
Rat	-	257	5 q36	Pink1	PTEN induced kinase 1

Previous and Unofficial Names

brpk | Parkinson disease (autosomal recessive) 6

Database Links
Alphafold	Q9BXM7 (Hs), Q99MQ3 (Mm)
BRENDA	2.7.11.1
ChEMBL Target	CHEMBL3337330 (Hs)
Ensembl Gene	ENSG00000158828 (Hs), ENSMUSG00000028756 (Mm), ENSRNOG00000015385 (Rn)
Entrez Gene	65018 (Hs), 68943 (Mm), 298575 (Rn)
Human Protein Atlas	ENSG00000158828 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:65018 (Hs), mmu:68943 (Mm), rno:298575 (Rn)
OMIM	608309 (Hs)
Orphanet	ORPHA117822 (Hs)
Pharos	Q9BXM7 (Hs)
RefSeq Nucleotide	NM_032409 (Hs), NM_026880 (Mm), NM_001106694 (Rn)
RefSeq Protein	NP_115785 (Hs), NP_081156 (Mm), NP_001100164 (Rn)
UniProtKB	Q9BXM7 (Hs), Q99MQ3 (Mm)
Wikipedia	PINK1 (Hs)

Enzyme Reaction
EC Number: 2.7.11.1

Download all structure-activity data for this target as a CSV file

Activators
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference MTK458 Hs Activation - - 1 ⤷ [1]
Activator Comments
Direct binding of MTK458 to PINK1 was demonstrated using a nano-BRET proximity assay [1].

Clinically-Relevant Mutations and Pathophysiology
Disease:  Parkinson disease 6, autosomal recessive early-onset; PARK6 Synonyms: Parkinson's disease [Disease Ontology: DOID:14330] Young adult-onset Parkinsonism [Orphanet: ORPHA2828] Disease Ontology: DOID:14330 OMIM: 605909 Orphanet: ORPHA2828